[Changes in immunogenesis organs after thyroidectomy and hormonal correction in an experiment]. / Izmeneniia organov immunogeneza posle tireoidéktomii i gormonalnoi korrektsii v éksperimente.

Regulating effect of thyroid hormones on functions of organs of the immune system has been demonstrated in the experiment. Deficiency of thyroid hormones affects thymulin synthesis and morphofunctional status of immunogenesis organs. Combination of thymostimulin and thyroxin in the thyroidectomized animals, as compared to their separate use, is pathogenetically the most adequate correcting therapy aiming normalization of structural and functional disorders in the thymus and spleen. Prolonged reaction of tissual basophils saturated with heparin, indicated hormonal activation of blood anticoagulative system, and complex of the above hormones can be used for prevention of thromboembolic complications.

[The mechanism of the immunomodulating action of Béres Drops Plus]. / O mekhanizme immunomoduliruiushchego deistviia kapel' Beresha Plius.

Béres Drops Plus were found to raise the number of E-RFCs, being formed by lymphocytes of peripheral blood of subjects presenting with low levels of T-cells, and to increase the production of substances possessing thymosine-like activity (STLA) by lymphocytes and epithelial cells of the murine thymus gland. In vitro the drug preparation in question enhances endocrine function of thymus in normal animals and the organism's capacity to induce STLA synthesis following thymectomy. These findings are useful in devising rational schemes of rehabilitation of immune system with the drug preparation Béres Drops Plus in secondary immunodeficiency states developing in cases presenting with precancer conditions, malignant neoplasia, in those subjects having taken part in the elimination of the Chernobyl NPP accident aftermath, those residing on the territories controlled, as well as evolving on account of aging.

[The status of the endocrine function of the thymus in acute radiation sickness resulting from the accident at the Chernobyl Nuclear Power Station]. / Sostoianie éndokrinnoi funktsii timusa pri ostroi luchevoi bolezni, voznikshei vsledstvie avarii na ChAES.

Data are presented on the role of inhibition of endocrine function of the thymus in the pathogenesis of acute radiation sickness resulted from the direct and indirect (via the increased glucocorticoid production) effects of ionizing radiation. The complex treatment, including nonspecific active immunotherapy, permitted to normalize the thymic hormone level and certain parameters of the immune system.

[Intensive preoperative gamma teletherapy combined with endogenous interferon induction in the treatment of stomach cancer]. / Intensivnaia predoperatsionnaia telegammaterapiia v sochetanii s induktsiei éndogennogo interferona pri lechenii raka zheludka.

The authors analyze results of combined treatment of 72 patients using preoperative intensive gamma teletherapy. Increase of 4-year survival was observed only in patients showing no regional metastases and equalled 18.7%. The authors worked out a method of preoperative radiation treatment against the background of induction of endogenous interferon by curantyl. The course of radiation therapy was carried out in association with a 2-3 times increase of the interferon levels in the blood and was accompanied by a reduction of the immunodepressive effect of gamma teletherapy on the body.

[Blood thymus hormone content in different types of neoplastic process and its changes as a result of chemotherapy and surgical removal of tumors]. / Soderzhanie gormonov timusa v krovi pri razlichnykh tipakh opukholevogo protsessa i ego izmenenie v rezul'tate khimioterapii i khirurgicheskogo udaleniia opukholi.

Levels of thymic hormones in blood serum were found to decrease during the development of Guerin's carcinoma, methylcholanthrene- and DMBA-induced carcinogenesis, soft tissue sarcomas, mammary cancer, in children with tumors of the urinary-genital tract, that evidences for the suppression of the thymic endocrine function in neoplastic processes. A decrease in the level of substances, active in the test under study is not revealed in patients with different forms of leukemias. The tumour elimination normalizes the thymic endocrine function, while multiagent chemotherapy increases the insufficiency. The data obtained suggest the immunotherapy for malignant neoplasms with thymic hormones.

[Characteristics of the inhibition of thymus endocrine function and synthesis of substances with thymosin-like activity caused by thymostimulin and splenin during DMBA-induced mammary gland carcinogenesis in rats]. / Osobennosti ugneteniia éndokrinnoi funktsii timusa i sinteza veshchestv s timozinpodobnoi aktivnost'iu, vyzyvaemoi timostimulinom i spleninom, pri DMBA-indutsirovannom kantserogeneze molochnykh zhelez u krys.

The contents of thymic hormones and endogenous substances with thymosin-like activity (TLA) was studied under conditions of administering thymostimulin and splenin during DMBA-induced carcinogenesis in rat mammary glands. It has been established that during latent carcinogenesis there is an inhibition of thymic endocrine function which persists in tumour-bearing animals. Injections of thymostimulin and splenin induce synthesis of substances with TLA, accompanied by an inhibition of blastoma development.

[Effect of corticosteroids on the secretion of the serum thymic factor and on the content of mast cell affinity lymphocytes in rats]. / Deistvie kortikosteroidov na sekretsiiu timusnogo syvorotochnogo faktora i soderzanie mastotsitaffinnykh limfotsitov u krys.

The level of thymus serum factor (TSF) was studied in the circulation of adrenalectomized rats and in the administration of corticosteroids. The effect of adrenocortical hormones on the receptor properties of thymocytes by the ability of mast cells to form mastolymphocytic rosettes (MLR) with thymocytes was also studied. The TSF content was shown to decrease to the level observed in thymectomized animals 40 h after administration of 125 mg/kg hydrocortisone. The MLR amount formed by thymocytes decreased significantly either. Adrenalectomy mas accompanied by an increase in the TSF content early after operation and at later time the MLR amount rose. Sham adrenalectomy resulted in a decrease in the TSF amount early after operation.