Detectores y aceleradores que curan / Curing detectors and accelerators / Detectores e aceleradores que curam

Los aceleradores y los detectores utilizados en las investigaciones en física de partículas sirven y han servido desde hace más de 100 años para la detección y cura de enfermedades. Gracias a los avances en la física experimental de partículas, se han desarrollado a lo largo de los años aceleradores más potentes y sistemas de detección más precisos y sofisticados. Estos, conjuntamente con los modernos sistemas de cómputo, han permitido aplicaciones hasta hace poco tiempo impensadas en la medicina. En este trabajo se esboza la historia de estos instrumentos, sus principios de funcionamiento y sus ventajas en las aplicaciones médicas, especialmente en el campo de la detección y tratamiento de tumores.(AU)

Accelerators and detectors used in particle physics research have been used for more than 100 years for detection and cure of diseases. Thanks to the progress in experimental particle physics, more powerful accelerators and more precise and sophisticated systems have been developed. These, together with modern computation systems have enabled applications in medicine not even thought of until recently. This work outlines the history of these instruments, their working principles and advantages for health applications, especially in the field of tumor detection and treatment.(AU)

Os aceleradores e os detectores utilizados nas pesquisas em física de partículas servem e tÛm servido já faz mais de 100 anos para a detecþÒo e cura de doenþas. Devido aos avanþos na física experimental de partículas, aceleradores mais potentes e sistemas de detecþÒo mais precisos e sofisticados tÛm sido desenvolvidos ao longo dos anos. Eles, junto com os modernos sistemas de c¶mputo, permitiram aplicaþ§es até pouco tempo atrás impensadas em medicina. Neste trabalho esboþamos a história destes instrumentos, seus princípios de funcionamento e suas vantagens nas aplicaþ§es médicas, especialmente no campo da detecþÒo e tratamento de tumores.(AU)

Detectores y aceleradores que curan / Curing detectors and accelerators / Detectores e aceleradores que curam

Los aceleradores y los detectores utilizados en las investigaciones en física de partículas sirven y han servido desde hace más de 100 años para la detección y cura de enfermedades. Gracias a los avances en la física experimental de partículas, se han desarrollado a lo largo de los años aceleradores más potentes y sistemas de detección más precisos y sofisticados. Estos, conjuntamente con los modernos sistemas de cómputo, han permitido aplicaciones hasta hace poco tiempo impensadas en la medicina. En este trabajo se esboza la historia de estos instrumentos, sus principios de funcionamiento y sus ventajas en las aplicaciones médicas, especialmente en el campo de la detección y tratamiento de tumores.

Accelerators and detectors used in particle physics research have been used for more than 100 years for detection and cure of diseases. Thanks to the progress in experimental particle physics, more powerful accelerators and more precise and sophisticated systems have been developed. These, together with modern computation systems have enabled applications in medicine not even thought of until recently. This work outlines the history of these instruments, their working principles and advantages for health applications, especially in the field of tumor detection and treatment.

Os aceleradores e os detectores utilizados nas pesquisas em física de partículas servem e têm servido já faz mais de 100 anos para a detecção e cura de doenças. Devido aos avanços na física experimental de partículas, aceleradores mais potentes e sistemas de detecção mais precisos e sofisticados têm sido desenvolvidos ao longo dos anos. Eles, junto com os modernos sistemas de cômputo, permitiram aplicações até pouco tempo atrás impensadas em medicina. Neste trabalho esboçamos a história destes instrumentos, seus princípios de funcionamento e suas vantagens nas aplicações médicas, especialmente no campo da detecção e tratamento de tumores.

[Ovarian cyst in a case of female pseudohermaphroditism in a patient with male phenotype]. / Cisti ovarica in paziente a fenotipo maschile e pseudoermafroditismo femminile. Caso clinico.

Female pseudohermaphroditism is an intersexual state distinguished by virilized external genitals and secondary sex characters in a XX subject. We report a case of female pseudohermaphroditism diagnosed later on the discovery of an abdominal mass, then revealed to be an enormous ovarian cyst. Hormonal dosages suggested the presence of partial surrenalic b-hydroxylase deficiency. For this reason the clinical picture was considered expression of an adreno-genital syndrome, displayed as female pseudohermaphroditism with Prader stage V virilization.

Acquisition of low-frequency signals immersed in noise by random sampling and finite impulse response filters.

This article presents a method for digital acquisition of low-frequency signals immersed in high-frequency noise when noise frequency is higher than the sampling one. This method uses no antialiasing filters, but random sampling and filtering instead. Its formulation is developed for JRS (jitter random sampling) and finite impulse response (FIR) filters. The proposed method is experimentally tested on three FIR filters: moving average, windowed linear phase, and constrained least square.

[Synchronous and metachronous tumours of colon cancer. A review of 5 years of experience (1999-2004)]. / I tumori sincroni e metacroni del colon-retto. Revisione di 5 anni di attività (1999-2004).

The authors report on 30 synchronous cancer (19%) and 9 metachronous cancer (5.7%) observed in 5 years (1999-2004) in 158 patient operated for colon cancer, defining metachronous cancer a tumor arisen at least 6 months after the first one or further then 5 cm from the anastomosis of the first colon resection. International case records report an incidence of 0.6-14% for synchronous cancer and 1-8% for metachronous cancer. The incidence of synchronous cancer is increasing for the presence of more oncogenic factors in the environment, for the improvement in radiology and endoscopy, for the raise of medium life. In accord with other authors, they show that the main risk factor for the developing of metachronous cancer is the coexistence of colon adenomas at the moment of the diagnosis of the tumor. The various incidence percentages can be explained by different way of diagnosis and classification.

[Different approaches for medical or surgical management of Crohn's disease: the importance of the classification of Vienna]. / Modalità di approccio chirurgico nei pazienti con morbo di Crohn: inquadramento secondo la classificazione di Vienna.

The Vienna classification of Crohn's disease provides defined criteria for a phenotypic classification of the disease, considering that phenotypic parameters reflect the contribution of both genetic and environmental factors to the expression of disease. The classification includes mainly three criteria as part of the natural course of disease: age at the diagnosis, location and behaviour and it provides distinct definitions to categorize Crohn' patients into 24 subgroups. In this study we attempt to define the clinical importance of the Vienna classification and the possibility to optimize medical care of Crohn's disease according to patient subgroups. Early age at the diagnosis is associated with a greater prevalence of a family history, greater small bowel involvement, more complicated stricturing disease and a higher frequency of surgery. Surgery is based on exact knowledge of location: L1 patients might profit the most from resective surgery, L4 patients from strictureplasty. Stricturing behaviour (B2) might be the most appropriate subgroup for surgical treatment. Penetrating behaviour (B3) is confirmed as an important risk for early postoperative recurrence; patients in the penetrating behaviour group (i.e. fistulas) have a specific indication for immunosuppressive or anti-tumour necrosis factor-alpha therapy.

A case of bilateral breast cancer and Graves' disease.

We report a case of bilateral breast cancer associated with Graves' disease characterized by a large goiter and complicated by a severe ophthalmopathy. The hyperthyroidism was treated initially with methimazole and then with thyroidectomy, the ophthalmopathy with intravenous steroids combined with orbital radiotherapy. The breast tumors underwent surgical resection followed by chemotherapy. We describe this case because of the well-known association between breast cancer and thyroid disease, particularly of the autoimmune type, the causes of this being still unclear. Recent literature on this topic is reviewed, discussing the possible role of the Na(+)-I(-) symporter and anti-TPO antibodies.