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1.
Transplant Proc ; 40(6): 2003-5, 2008.
Article in English | MEDLINE | ID: mdl-18675114

ABSTRACT

Lung transplantation (LT) is the only effective form of therapy for cystic fibrosis (CF) associated with end-stage pulmonary failure. In Italy, the management of CF is regulated by national law, which has instituted regional centers for care and follow-up of all CF patients. LT has been performed since 1992 in only nine LT certified centers. The structured national organization has led to a unified database for LT for CF. As of December 2006, 197 bilateral LT (96 male and 94 female patients; 7 retransplants) have been performed. Of these, four had also liver or heart and liver transplantation, and three are long-term survivors. Overall median survival is 7 years. Mean age at transplantation is 26.5 years, and the mortality on the waiting list is 33.6%. Patients listed for transplant either received a suitable donor within a mean of 10 months or died within a mean of 5.5 months. The most frequent cause of death is bronchiolitis obliterans syndrome (BOS). Our nationwide database indicates the excellent results obtained by LT in FC. Still, mortality on the waiting list remains a challenge and long-term outcome is limited by BOS.


Subject(s)
Cystic Fibrosis/surgery , Lung Transplantation/statistics & numerical data , Bronchiolitis Obliterans/epidemiology , Cystic Fibrosis/complications , Female , Humans , Italy , Male , Postoperative Complications/classification , Postoperative Complications/epidemiology , Reoperation/statistics & numerical data , Respiratory Insufficiency/etiology , Respiratory Insufficiency/surgery , Retrospective Studies , Treatment Outcome
14.
Osp Ital Chir ; 16(1): 99-112, 1967 Jan.
Article in Italian | MEDLINE | ID: mdl-4876046

Subject(s)
Melanoma , Humans
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