ABSTRACT
IntroducciónSegún las clasificaciones actuales, el metabolito de mayor interés clínico para valorar la dotación de vitamina D3 es el 25-hidroxivitamina D3 con un intervalo de referencia en 1070ng/ml, aunque muchos autores consideran como deseable valores por sobre 40ng/ml o 100nmol/l. Según estas definiciones, en España tres de cada cuatro personas tendrían carencias de vitamina D3.Material y métodoSe ha utilizado una técnica radioinmunoensayo-CT para el diagnóstico de la 25hidroxivitamina D3 para ver el estatus en la población. Posteriormente, se ha realizado un estudio de casos y controles para conocer la relación entre diferentes enfermedades y carencias de vitamina D3.ResultadosEl 73,2% de los casos se encuentra en rangos considerados aceptables, según la clasificación actual, y el grupo control, mujeres menopáusicas sanas que no recibían ningún tipo de suplemento vitamínico, se encuentra con niveles desde 40ng/ml en un 100%.Discusión y conclusionesSegún nuestro estudio, los niveles de vitamina D3 han cambiado, pasando de una alta prevalencia de insuficiencia de vitamina D3 a rangos aceptables en un 26,8% de la población, con una mediana de 46,2ng/ml, considerando como rango de referencia 1070ng/ml(AU)
IntroductionAccording to current classifications, the metabolite of greatest clinical interest to evaluate vitamin D3 dosage is 25-hydroxyvitamin D3 with a reference interval of approximately 1070ng/ml, although many authors consider values of approximately 40ng/ml or 100nmol/l to be desirable. According to these definitions, three out of four people in Spain would have vitamin D3 deficiency.Material and methodThe RIA-CT technique was used for diagnosis of 25(OH)D3 to determine the population status. Subsequently, a case-control study was performed to evaluate the relationship between distinct diseases and vitamin D3 deficiency.ResultsA total of 73.2% of the cases were found to be within the range considered acceptable, according to the present classification. One hundred percent of the control group and healthy menopausal women who did not receive any kind of vitamin supplement had levels of 40ng/ml or more.Discussion and conclusionsOur results indicate that the prior situation of a high prevalence of vitamin D3 deficiency has improved and that levels are now acceptable in 26.8% of the population, with a mean value of 46.2ng/ml, considering 1070ng/ml as the reference range(AU)
Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Cholecalciferol/therapeutic use , Cholecalciferol/pharmacology , Menopause , Avitaminosis/diagnosis , Avitaminosis/therapy , Vitamin D Deficiency/therapy , Case-Control Studies , Cholecalciferol/administration & dosage , Bone Density Conservation Agents/therapeutic useABSTRACT
INTRODUCTION: According to current classifications, the metabolite of greatest clinical interest to evaluate vitamin D(3) dosage is 25-hydroxyvitamin D(3) with a reference interval of approximately 10-70ng/ml, although many authors consider values of approximately 40ng/ml or 100nmol/l to be desirable. According to these definitions, three out of four people in Spain would have vitamin D(3) deficiency. MATERIAL AND METHOD: The RIA-CT technique was used for diagnosis of 25(OH)D(3) to determine the population status. Subsequently, a case-control study was performed to evaluate the relationship between distinct diseases and vitamin D(3) deficiency. RESULTS: A total of 73.2% of the cases were found to be within the range considered acceptable, according to the present classification. One hundred percent of the control group and healthy menopausal women who did not receive any kind of vitamin supplement had levels of 40 ng/ml or more. DISCUSSION AND CONCLUSIONS: Our results indicate that the prior situation of a high prevalence of vitamin D(3) deficiency has improved and that levels are now acceptable in 26.8% of the population, with a mean value of 46.2 ng/ml, considering 10-70 ng/ml as the reference range.
