Universal Free-Fall Law for Liquid Jets under Fully Developed Injection Conditions.

We show that vertical slender jets of liquid injected in air with a fully developed outlet velocity profile have a universal shape in the common case in which the viscous force is much smaller than the gravitational force. The theory of ideal flows with vorticity provides an analytical solution that, under negligible surface-tension forces, predicts R_{j}(Z)=[(1+Z/4)^{1/2}-(Z/4)^{1/2}]^{1/2}, where R_{j} is the jet radius scaled with the injector radius and Z is the vertical distance scaled with the gravitational length, l_{g}=u_{o}^{2}/2g, where u_{o} is the mean velocity at the injector outlet and g is the gravitational acceleration. In contrast with Mariotte's law, R_{j}=(1+Z)^{-1/4}, previously reported experiments employing long injectors collapse almost perfectly onto the new solution.

Opioid Addiction: Social Problems Associated and Implications of Both Current and Possible Future Treatments, including Polymeric Therapeutics for Giving Up the Habit of Opioid Consumption.

BACKGROUND: Detoxification programmes seek to implement the most secure and compassionate ways of withdrawing from opiates so that the inevitable withdrawal symptoms and other complications are minimized. Once detoxification has been achieved, the next stage is to enable the patient to overcome his or her drug addiction by ensuring consumption is permanently and completely abandoned, only after which can the subject be regarded as fully recovered. METHODS: A systematic search on the common databases of relevant papers published until 2016 inclusive. RESULTS AND CONCLUSION: Our study of the available oral treatments for opioid dependence has revealed that no current treatment can actually claim to be fully effective. These treatments require daily oral administration and, consequently, regular visits to dispensaries, which in most cases results in a lack of patient compliance, which causes fluctuations in drug plasma levels. We then reviewed alternative treatments in the available scientific literature on polymeric sustained release formulations. Research has been done not only on release systems for detoxification but also on release systems for giving up the habit of taking opioids. These efforts have obtained the recent authorization of polymeric systems for use in patients that could help them to reduce their craving for drugs.

¿Qué gestante con PTI requiere un seguimiento más estrecho? / What pregnant woman with PTI requires closer tracking?

Nuestro objetivo es establecer si existe alguna característica que pueda determinar qué gestante con púrpura trobótica idiopática es más sensible que otra, y por tanto necesita un seguimiento médico más estrecho. Los datos se han recogido de forma retrospectiva a partir de pacientes embarazadas en seguimiento entre 1999 y 2014 con diagnóstico confirmado de púrpura trobótica idiopática. Se recogió información de 57 embarazos en 43 mujeres. Dentro de nuestra muestra, 46 mujeres habían sido previamente diagnosticadas (80,7%). A favor de aquellas con púrpura trobótica idiopática crónica, identificamos varios datos que demostraron correlación significativa, tales como los síntomas hemorrágicos. No encontramos, sin embargo, ninguna relación entre la severidad de la trombopenia maternal y los resultados neonatales, además, ninguno de los recién nacidos sufrieron síntomas hemorrágicos. Aquellas pacientes que fueron diagnosticadas de forma aguda requirieron un seguimiento médico más estrecho teniendo en cuenta que tienen un riesgo aumentado de descompensarse (AU)

Our aim was to establish if there were some features that could determine which pregnant woman who suffered from idiopathic thrombocytopenic purpura was more sensitive and therefore needs more accurate medical monitoring than others. Data were collected retrospectively from pregnant patients followed-up from 1999 to 2014 with a clear diagnosis of idiopathic thrombocytopenic purpura, with a total of 57 pregnancies in 43 women. Among our sample 46 women had been previously diagnosed (80.7%). In favor of those with chronic idiopathic thrombocytopenic purpura we identified several data which showed significant correlation as symptoms in the gestation. We did not find any correlation between the severity of maternal platelet counting and the neonatal outcomes, as well as any newborn suffered hemorrhagic symptoms. As we could see in our study, those pregnant women who are diagnosed with idiopathic thrombocytopenic purpura acutely require closer medical monitoring due to they have an increased risk to become unbalanced (AU)

Virus Zika y gestación / Zika virus and pregnancy

No disponible

Executive summary of the Consensus Statement on monitoring HIV: pregnancy, birth, and prevention of mother-to-child transmission.

The main objective in the management of HIV-infected pregnant women is prevention of mother-to-child transmission; therefore, it is essential to provide universal antiretroviral treatment, regardless of CD4 count. All pregnant women must receive adequate information and undergo HIV serology testing at the first visit. If the serological status is unknown at the time of delivery, or in the immediate postpartum, HIV serology testing has to be performed as soon as possible. In this document, recommendations are made regarding the health of the mother and from the perspective of minimizing mother-to-child transmission.

Influence of a combination of agricultural chemicals on embryos of the endangered gold-striped salamander (Chioglossa lusitanica).

Pollution from agrochemicals may be contributing to the global decline of amphibian populations. Environmentally relevant concentrations of a fertiliser, ammonium nitrate, and a commercial formulation of the herbicide glyphosate Roundup Plus were tested on the embryonic development of Chioglossa lusitanica. This study introduces new data at three different levels. First, we provide previously unknown information about hatchling traits of C. lusitanica. Second, we present the first ecotoxicological study of this endangered species, to which environmental pollution is considered a major threat. Third, we conduct the first experiment with an amphibian species exposed to a mixture of a glyphosate-based herbicide and a nitrogenous fertiliser. Control individuals hatched with an average (±SD) total length of 18.77 (±2.02) mm and at an average Harrison's developmental stage of 44.58 (±1.24). Mean hatching time among controls was 11.52 (±1.29) weeks. None of the chemicals or their interaction produced lethal effects; however, a significant interaction was found when analysing total length at hatching. Individuals exposed to the herbicide hatched at a larger size than controls, and this effect was especially clear when the fertiliser was added to the water. The absence of pollutant-related mortality or severe sublethal effects is in agreement with most studies indicating a high tolerance of amphibian embryos to agrochemicals. However, further research considering other life stages and additional natural factors (i.e., predators, food availability) is needed to estimate the ecological impact of chemical mixtures on C. lusitanica.

Tratamiento con fulvestrant en mujeres posmenopáusicas con cáncer de mama avanzado tras tratamiento hormonal previo / Fulvestrant in heavily pretreated postmenopausal women with advanced breast cancer

Fundamento y objetivo: Fulvestrant es un antiestrógeno puro que ha demostrado eficacia en cáncer de mama avanzado como tratamiento de segunda línea tras progresión a tamoxifeno. El objetivo del trabajo fue describir la experiencia clínica con fulvestrant y evaluar su eficacia y tolerabilidad. Material y método: 36 mujeres posmenopáusicas con cáncer de mama avanzado recibieron tratamiento con fulvestrant. El 62,8% de las pacientes recibió fulvestrant al menos en tercera línea. Resultados: El 91,4% había recibido tratamiento hormonal previo en la enfermedad avanzada y más del 50%, quimioterapia. La enfermedad metastásica fue visceral en un 5,7%, no visceral en un 54,3% y en ambas localizaciones en un 40%. Se obtuvo un 11,4% de respuestas parciales (RP), un 22,9% presentó estabilidad de la enfermedad (EE), alcanzando beneficio clínico (BC) el 31,4% de las pacientes. La mediana de tiempo a la progresión (TTP) fue de 4,18 meses (intervalo de confianza del 95% [IC] del 95%, 2,6–5,7 meses), mientras que la mediana de supervivencia global (SG) no se ha alcanzado, con una mediana de seguimiento de 8,9 meses. Se produjeron eventos adversos de grado I–II en un 22,9% de las pacientes. Conclusiones: Fulvestrant es un fármaco bien tolerado, que representa una eficaz opción de tratamiento hormonal en el cáncer de mama avanzado intensamente tratado con hormonoterapia y quimioterapia (AU)

Background and objective: Fulvestrant (Flv) is a pure antiestrogen without agonist activity. Flv is effective as second line treatment in postmenopausal women with advanced breast cancer after tamoxifen. Material and method: We performed a retrospective study of 36 consecutive postmenopausal women treated with Flv and advanced breast cancer progressing on prior therapies. 62,8% received Flv as third line treatment or more (all patients had previously received endocrine treatment for early or advanced breast cancer), 54,3% adjuvant chemotherapy and 67,5% received chemotherapy for metastatic disease. Our objective was to analyze the response rate, clinical benefit, time to progression (TTP) and toxicity profile. Results: In our study 11,4% patients had partial responses (PR) and 22,9% had a stable disease (SD) >24 weeks. Clinical benefit rate (CB) [RP+RC+SD]: 31,4%. TTP: 4,2 months (CI 95%, 2,6–5,8), with a median follow-up of 8,9 months. Flv was well tolerated, 22,9% patients had adverse events, all grade I/II, and only 5,7% of women gave up the treatment. Conclusions: These data demonstrate that Flv is an effective and safe therapy for heavily pre-treated postmenopausal women with advanced breast cancer (AU)

[Fulvestrant in heavily pretreated postmenopausal women with advanced breast cancer]. / Tratamiento con fulvestrant en mujeres posmenopáusicas con cáncer de mama avanzado tras tratamiento hormonal previo.

BACKGROUND AND OBJECTIVE: Fulvestrant (Flv) is a pure antiestrogen without agonist activity. Flv is effective as second line treatment in postmenopausal women with advanced breast cancer after tamoxifen. MATERIAL AND METHOD: We performed a retrospective study of 36 consecutive postmenopausal women treated with Flv and advanced breast cancer progressing on prior therapies. 62,8% received Flv as third line treatment or more (all patients had previously received endocrine treatment for early or advanced breast cancer), 54,3% adjuvant chemotherapy and 67,5% received chemotherapy for metastatic disease. Our objective was to analyze the response rate, clinical benefit, time to progression (TTP) and toxicity profile. RESULTS: In our study 11,4% patients had partial responses (PR) and 22,9% had a stable disease (SD) >24 weeks. Clinical benefit rate (CB) [RP+RC+SD]: 31,4%. TTP: 4,2 months (CI 95%, 2,6-5,8), with a median follow-up of 8,9 months. Flv was well tolerated, 22,9% patients had adverse events, all grade I/II, and only 5,7% of women gave up the treatment. CONCLUSIONS: These data demonstrate that Flv is an effective and safe therapy for heavily pre-treated postmenopausal women with advanced breast cancer.

Primary ovarian Burkitt lymphoma.

Primary ovarian Burkitt lymphoma (BL) is a rare neoplasm in adults. We report a 30-year-old woman diagnosed with primary bilateral ovarian BL. She presented features of a twisted ovarian cyst and underwent bilateral salpingo-oophorectomy. The histopathologic evaluation yielded the diagnosis of BL and subsequently she received chemoimmunotherapy with CODOX-M-IVAC plus rituximab (anti-CD20 monoclonal antibody).

1-Hydroxymethyl-4-phenylsulfonybutadiene, a versatile building block for the synthesis of 2,3,4-trisusbtituted tetrahydrothiophenes.

A method to synthesize chiral 2,3,4-trisusbtituted tetrahydrothiophenes in both enantiomerically pure forms starting from 1-hydroxymethyl-4-phenylsulfonylbutadiene is described.

Chemistry of epoxysulfones: straightforward synthesis of versatile chiral building blocks.

[reaction: see text] Several chiral building blocks have been obtained easily in large quantities from an epoxysulfone (9) that could be obtained in both enantiomeric forms from accessible starting materials.

Synthesis and structure-activity relationships of a new model of arylpiperazines. 1. 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1, 3-dioxoperhydroimidazo[1,5-alpha]pyridine: a selective 5-HT1A receptor agonist.

A series of new bicyclohydantoin-arylpiperazines was prepared and evaluated for affinity at 5-HT1A, alpha 1, and D2 receptors. Most of the compounds showed very low affinity for D2 receptors, and most of them demonstrated moderate to high affinity for 5-HT1A and alpha 1 receptor binding sites. SAR observations indicated that the length of the alkyl chain between the arylpiperazine and the hydantoin moiety is of great importance for 5-HT1A/alpha 1 affinity and selectivity, n = 1 being the optimal value. Compound 1h, 2-[[4-(o-methoxyphenyl)piperazin-1-yl] methyl]-1,3-dioxoperhydroimidazo [1,5-alpha]pyridine, bound at 5-HT1A sites with nanomolar affinity (Ki = 31.7 nM) and high selectivity over alpha 1, D2, and 5-HT2A receptors (Ki > 1000, > 10 000, and > 1000 nM, respectively). Preliminary studies showed that this agent is probably functioning as a partial to full 5-HT1A agonist, and it displayed anxiolytic activity on the social interaction test in mice.

Spontaneous regression of pulmonary metastases and long-term survival of a patient with metastatic renal cell carcinoma, after immunostimulation with bacillus Calmette-Guérin and extirpation of brain and contralateral lung metastases.

A 52-year-old patient underwent left radical nephrectomy for renal cell carcinoma and received adjuvant chemotherapy postoperatively with adriamycin and 5-fluoruracil. Twenty months afterwards he developed cerebral and multiple bilateral pulmonary metastases. The cerebral metastasis was excised and nonspecific immunostimulation with bacillus Calmette-Guérin was initiated. Two years later the other secondaries had scarcely grown and extirpation of the two right pulmonary metastases was undertaken. Few months afterwards the two left pulmonary nodules disappeared. The patient continues free of disease more than 5 years after nephrectomy and 16 months after regression of the lung metastases.