Mortality Risk Prediction in Abdominal Septic Shock Treated with Polymyxin-B Hemoperfusion: A Retrospective Cohort Study.

Endotoxin, a component of the cell membrane of gram-negative bacteria, is a trigger for dysregulated inflammatory response in sepsis. Extracorporeal purification of endotoxin, through adsorption with polymyxin B, has been studied as a therapeutic option for sepsis. Previous studies suggest that it could be effective in patients with high endotoxin levels or patients with septic shock of moderate severity. Here, we perform a retrospective, single-centre cohort study of 93 patients suffering from abdominal septic shock treated with polymyxin-B hemoperfusion (PMX-HP) between 2015 and 2020. We compared deceased and surviving patients one month after the intervention using X2 and Mann-Whitney U tests. We assessed the data before and after PMX-HP with a Wilcoxon single-rank test and a multivariate logistic regression analysis. There was a significant reduction of SOFA score in the survivors. The expected mortality using APACHE-II was 59.62%, whereas in our sample, the rate was 40.9%. We found significant differences between expected mortality and real mortality only for the group of patients with an SOFA score between 8 and 13. In conclusion, in patients with abdominal septic shock, the addition of PMX-HP to the standard therapy resulted in lower mortality than expected in the subgroup of patients with intermediate severity of illness.

COVID-19 associated infections in the ICU setting: A retrospective analysis in a tertiary-care hospital.

INTRODUCTION: Our work describes the frequency of superinfections in COVID-19 ICU patients and identifies risk factors for its appearance. Second, we evaluated ICU length of stay, in-hospital mortality and analyzed a subgroup of multidrug-resistant microorganisms (MDROs) infections. METHODS: Retrospective study conducted between March and June 2020. Superinfections were defined as appeared ≥48h. Bacterial and fungal infections were included, and sources were ventilator-associated lower respiratory tract infection (VA-LRTI), primary bloodstream infection (BSI), secondary BSI, and urinary tract infection (UTI). We performed a univariate analysis and a multivariate analysis of the risk factors. RESULTS: Two-hundred thirteen patients were included. We documented 174 episodes in 95 (44.6%) patients: 78 VA-LRTI, 66 primary BSI, 9 secondary BSI and 21 UTI. MDROs caused 29.3% of the episodes. The median time from admission to the first episode was 18 days and was longer in MDROs than in non-MDROs (28 vs. 16 days, p<0.01). In multivariate analysis use of corticosteroids (OR 4.9, 95% CI 1.4-16.9, p 0.01), tocilizumab (OR 2.4, 95% CI 1.1-5.9, p 0.03) and broad-spectrum antibiotics within first 7 days of admission (OR 2.5, 95% CI 1.2-5.1, p<0.01) were associated with superinfections. Patients with superinfections presented respect to controls prolonged ICU stay (35 vs. 12 days, p<0.01) but not higher in-hospital mortality (45.3% vs. 39.7%, p 0.13). CONCLUSIONS: Superinfections in ICU patients are frequent in late course of admission. Corticosteroids, tocilizumab, and previous broad-spectrum antibiotics are identified as risk factors for its development.

COVID-19 associated infections in the ICU setting: A retrospective analysis in a tertiary-care hospital.

Introduction: Our work describes the frequency of superinfections in COVID-19 ICU patients and identifies risk factors for its appearance. Second, we evaluated ICU length of stay, in-hospital mortality and analyzed a subgroup of multidrug-resistant microorganisms (MDROs) infections. Methods: Retrospective study conducted between March and June 2020. Superinfections were defined as appeared ≥48 h. Bacterial and fungal infections were included, and sources were ventilator-associated lower respiratory tract infection (VA-LRTI), primary bloodstream infection (BSI), secondary BSI, and urinary tract infection (UTI). We performed a univariate analysis and a multivariate analysis of the risk factors. Results: Two-hundred thirteen patients were included. We documented 174 episodes in 95 (44.6%) patients: 78 VA-LRTI, 66 primary BSI, 9 secondary BSI and 21 UTI. MDROs caused 29.3% of the episodes. The median time from admission to the first episode was 18 days and was longer in MDROs than in non-MDROs (28 vs. 16 days, p < 0.01). In multivariate analysis use of corticosteroids (OR 4.9, 95% CI 1.4-16.9, p 0.01), tocilizumab (OR 2.4, 95% CI 1.1-5.9, p 0.03) and broad-spectrum antibiotics within first 7 days of admission (OR 2.5, 95% CI 1.2-5.1, p < 0.01) were associated with superinfections. Patients with superinfections presented respect to controls prolonged ICU stay (35 vs. 12 days, p < 0.01) but not higher in-hospital mortality (45.3% vs. 39.7%, p 0.13). Conclusions: Superinfections in ICU patients are frequent in late course of admission. Corticosteroids, tocilizumab, and previous broad-spectrum antibiotics are identified as risk factors for its development.

Introducción: Nuestro trabajo describe la frecuencia de sobreinfecciones en pacientes con COVID-19 en UCI e identifica factores de riesgo asociados con su aparición. Secundariamente, evaluamos la estancia en UCI, mortalidad intrahospitalaria y analizamos un subgrupo de infecciones causadas por microorganismos multirresistentes (MDR). Métodos: Estudio realizado entre marzo y junio de 2020. Definimos como sobreinfección a aquellas que aparecieron ≥48 h del ingreso. Incluimos las causadas por bacterias y hongos y evaluamos la infección respiratoria asociada a la ventilación mecánica (IRAVM), bacteriemia primaria, bacteriemia secundaria e infección del tracto urinario. Se realizó un análisis multivariante de los factores de riesgo. Resultados: Incluimos 213 pacientes, documentándose 174 episodios de sobreinfección en 95 casos (44,6%): IRAVM 78 episodios, bacteriemia primaria 66, bacteriemia secundaria 9 e ITU 21. Los MDR causaron el 29,3% de los episodios. La mediana de tiempo hasta el primer episodio fue de 18 días, siendo mayor en las causadas por MDR vs. no MDR (28 vs. 16, p < 0,01). El análisis multivariante identificó la administración de corticoides (OR 4,9 IC 95% 1,4-16,9), tocilizumab (OR 2,4 IC 95% 1,1-5,9) y antibióticos de amplio espectro (OR 2,5 IC 95% 1,2-5,1) como factores de riesgo asociados. Los pacientes con sobreinfección presentaron una estancia en UCI más prolongada (35 vs. 12 días, p < 0,01) pero no mayor mortalidad intrahospitalaria (45,3% vs. 39,7%, p 0,13). Conclusiones: Las sobreinfecciones en los pacientes con COVID-19 aparecen tardíamente. La administración de corticoides, tocilizumab y antibióticos de amplio espectro se asocia con su aparición.

Systemic and alveolar inflammatory response in the dependent and nondependent lung in patients undergoing lung resection surgery: A prospective observational study.

BACKGROUND: Measurement of inflammatory mediators in bronchoalveolar lavage (BAL) during lung resection surgery with periods of one-lung ventilation (OLV) has revealed an intense local pulmonary response. The role of each lung in the inflammation that occurs during this procedure has never been investigated. OBJECTIVE(S): The primary objective of our study was to compare the inflammatory response in the dependent lung with that of the nondependent lung by measuring inflammatory markers in BAL. Our secondary objective was to assess the behaviour of these inflammatory mediators in patients with and without postoperative pulmonary complications (PPCs). DESIGN: A prospective, observational study. SETTING: Department of Anaesthesiology in a university hospital. PATIENTS: Forty-six consecutive patients undergoing lung resection surgery. INTERVENTION(S): BAL samples were taken from dependent and nondependent lung 10 min before initiating OLV and at the end of OLV (once two-lung ventilation was established). All patients were followed up until 30 days after surgery. MAIN OUTCOME MEASURES: The concentration of cytokines [interleukin (IL)-1, IL-2, IL-6, IL-10, tumour necrosis factor-alpha (TNF-α)], nitric oxide, carbon monoxide and matrix metalloproteinase 2 (MMP-2) was analysed in both lungs before and after OLV. PPCs were recorded. RESULTS: In BAL fluid, all measured biomarkers, apart from IL-10, were significantly greater (P < 0.05) at the end of OLV than those obtained before OLV, both for the dependent and nondependent lung. The increase in measured biomarkers was similar in both lungs. Eight patients developed PPC. Patients who developed PPC had higher levels of TNF-α (P < 0.05) in BAL from the nondependent lung before and after OLV than patients who did not have PPC. Patients who developed PPC had a smaller increase in MMP-2 levels (P < 0.05) in the dependent lung than patients who did not have PPC. CONCLUSION: In lung resection surgery, the inflammatory response is similar in both lungs. However, the greater increase in TNF-α levels in the nondependent lung and the smaller increase of MMP-2 concentration in the dependent lung may increase the susceptibility to develop PPC.

Galardones europeos a las buenas prácticas en seguridad y salud en el trabajo / European good practice awards on safety and health at work

No disponible

Red Española de Seguridad y Salud en el Trabajo: una red de información fundamental en el ámbito de la prevención de riesgos / Spanish Network of Safety and Health at Work: a network of critical information in the field of risk prevention

No disponible

Síndrome de apnea hipopnea durante el sueño asociado al sobrepeso y la obesidad como factores de riesgo en patología restrictiva pulmonar / Apnea hypopnea during sleep associated with overweight and obesity as risk factors for pulmonary restrictive disorders

Objetivo: determinar la relación entre el sobrepeso, la obesidad y los trastornos del sueño del tipo apnea e hipopnea, como factores de riesgo con la patología restrictiva pulmonar. Método: en este estudio prospectivo fueron evaluados 50 pacientes que padecen de sobrepeso u obesidad, quienes fueron sometidos a la prueba de polisomnografía del sueño, usándose los datos clínicos de las historias, 02 espirómetros para evaluar la función respiratoria, un tallímetro y una balanza, ambos equipos calibrados. Resultados: los datos no muestran una asociación significativa (p> .05) entre el síndrome de apnea e hipopnea con el sobrepeso y la obesidad para presentar un patrón restrictivo pulmonar. Conclusiones: no se ha hallado que el sobrepeso, la obesidad, y el trastorno del sueño sean factores de riesgo que se asocian positivamente a la patología pulmonar restrictiva: asimismo, sólo se ha hallado una correlación o asociación positiva bajo y no significativa entre las variables sobrepeso, obesidad y trastornos del sueño del tipo apnea e hipopnea, con la presenciad e la patología pulmonar restrictiva.

Respuesta a la intervención nutricional en pacientes con enfermedad pulmonar obstructiva crónica (EPOC) leve a moderada / Response to nutritional intervention in patients with chronic obstructive pulmonary disease (COPD) mild to moderate

Objetivo. Determinar si la intervención nutricional en paciente con EPOC (Enfermedad Pulmonar obstructiva Crónica) tiene respuestas positivas en la mejora de los síntomas y en los valores espirométricos que señalan el funcionamiento de la vía ventilatoria. Sujetos y Métodos. Se evaluaron 23 pacientes que asisten al Servicio de Neumología de una clínica de Lima. Se uso un diseño cuasi-experimental utilizando un grupo experimental y un grupo control, teniendo como variable independiente el Programa Nutricional. Se hicieron mediciones antropométricas y pruebas de espirometría. El Programa de Intervención Nutricional fue de 2600 cal, se componía de un 30% de aporte de hidratos de carbono, de un 58% de grasas y de un 12% de proteínas. Resultados. El programa nutricional no genero cambios significativos en la vía ventilatoria medida a través de los siguientes indicadores: FEV1 (Volumen Expiratorio Forzado en un segundo), FVC (Capacidad Vital Forzada), FEV1/FVC (Volumen Expiratorio Forzado en un segundo/Capacidad Vital Forzada) IMC (Índice Masa Corporal), albumina sérica y frecuencia alimentaria. Conclusión. No se probado en este grupo especifico de pacientes que el Programa Nutricional provoca efectos decisivos para lograr cambios en las variables de la vía ventilatoria.

Aportación para el diagnóstico de cansancio en el desempeño del rol de cuidador / Contribution to the diagnosis of caregiver role strain

Objetivos. Determinar la concordancia entre la valoración que el cuidador hace sobre encontrar o no dificultad para desempeñar el papel de cuidador y la valoración de la enfermera. Medir el grado de cansancio de una manera cuantitativa y establecer el punto de corte que magnifique los valores predictivos de esta medida con los medios diagnósticos anteriores. Determinar la asociación entre las características definitorias y los factores relacionados de la North American Nursing Diagnosis Association (NANDA) con la presencia de cansancio. Método. Estudio analítico transversal sobre los cuidadores de personas discapacitadas de una zona básica de salud. Muestra aleatoria simple de 49 sujetos. El grado cuantitativo de cansancio se midió con el cuestionario de Zarit; la concordancia con el índice kappa y la asociación con el test de Spearman. Resultados. La concordancia entre la valoración es de 0,54. El cuestionario de Zarit presenta un punto de interés: 43/44. Encontramos asociación entre el diagnóstico y 4 características definitorias y 5 factores relacionados. Conclusiones. La concordancia entre la valoración de la cuidadora y de la enfermera es moderada. Las cuidadoras con más de 43 puntos en la escala de Zarit estarían cansadas con una alta probabilidad. Para minimizar la incertidumbre diagnóstica es importante la valoración de las características definitorias y los factores relacionados que presentan asociación positiva con el diagnóstico

We analyze difficulties in making a diagnosis of caregiver role strain and aim to suggest improvements in nursing interventions. Aims. To determine the concordance between evaluations made by caregivers and nurses on role strain. To quantitatively measure subjective burden and establish a cut-off point to increase predictive values. To determine the associations among defining characteristics and factors related to caregiver role strain. Method. We performed an analytical, cross-sectional study of the care providers of persons with loss of mobility in a basic health area. Forty-nine subjects were selected by simple random sampling. Quantitative measurement of the degree of strain was measured using the Zarit Burden Interview (ZBI). The concordance between determinations was measured using the kappa statistic and associations were measured using Spearman's test. Results. The concordance between caregivers' and nurses' evaluations was 0.54. The ZBI presented a cut-off point of 43/44. Associations were found among the diagnosis and four defining characteristics and five strain-related factors. Conclusions. Moderate concordance was found between caregivers' and nurses' evaluations. Caregivers with a score of more than 43 points on the ZBI had a high probability of experiencing strain. To minimize diagnostic uncertainty, defining characteristics and strain-related factors should be evaluated

[Postoperative fever]. / Fiebre postoperatoria.

The authors evaluate the most frequent causes of hyperthermia during postoperative periods. They develop their article in a chronological manner in order to make a more didactic presentation. The authors also include a short review of other less frequent causes for postoperation fever and they analyze the most common situation when an altered fever response occurs.

Fiebre postoperatoria / Postoperation fever

Se valoran las causas más frecuentes de hipertermia en el postoperatorio. Con la finalidad de presentar un artículo más didáctico se desarrollan de forma cronológica. Se efectúa un breve repaso de otras causas de fiebre postoperatoria menos frecuentes y se analizan las situaciones más habituales de respuesta febril alterada. (AU)