1.
Chem Asian J
; 18(13): e202300157, 2023 Jul 03.
Article
in English
| MEDLINE
| ID: mdl-37156742
ABSTRACT
A sustainable and easy-to-use protocol for the alkylation of aryl nitriles with the earth-abundant manganese(I) catalyst is presented. The alkylation reaction employs readily available nitriles and naturally abundant alcohols as the coupling partners. The reaction proceeds chemoselectively and encompasses a broad substrate scope with good to excellent yields. The catalytic reaction yields selectively α-branched nitriles and water as the sole byproduct. Experimental studies were executed to understand the mechanism of the catalytic reaction.