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Cyclophosphamide treatment in steroid-sensitive nephrotic syndrome of childhood.

Barratt, T M; Bercowsky, A; Osofsky, S G; Soothill, J F.

Lancet ; 1(7898): 55-8, 1975 Jan 11.

Article in English | MEDLINE | ID: mdl-46019

ABSTRACT

An 8-week course of 3 mg. per kg. body-weight per day of cyclophosphamide was administered to eighty-two children with steroid-senstitive nephrotic syndrome. One died, and of the remainder, 69% were in remission after 1 year and 44% after 4-years. Older children and those in whom cyclophosphamide was given during a steroid-maintained remission fared better.

Subject(s)

Cyclophosphamide/therapeutic use , Nephrotic Syndrome/drug therapy , Prednisolone/therapeutic use , Administration, Oral , Adolescent , Albuminuria/diagnosis , Body Height , Body Weight , Child , Child, Preschool , Complement System Proteins , Creatine/urine , Cyclophosphamide/administration & dosage , Drug Resistance , Drug Therapy, Combination , Female , Humans , Immunodiffusion , Immunoglobulin G/isolation & purification , Infant , Leukocyte Count , Male , Nephrotic Syndrome/immunology , Nephrotic Syndrome/metabolism , Prednisolone/administration & dosage , Proteinuria/drug therapy , Recurrence , Remission, Spontaneous , Time Factors

ABSTRACT

Subject(s)

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