Subject(s)
Blood Coagulation/drug effects , Coronary Artery Bypass/adverse effects , Coronary Disease/surgery , Heparin/administration & dosage , Thrombosis/prevention & control , Adult , Chronic Disease , Coronary Disease/blood , Humans , Intraoperative Complications/prevention & control , Middle Aged , Thrombosis/etiologyABSTRACT
The important role of toxemia in the pathogenesis of cadiogenic shock was demonstrated in 38 experiments on dogs. It was found that the blood becomes toxic later than the lymph. Lymphosorption arrests the progress of toxemia but does not relieve it if it has already developed. The hemosorption method produced a good effect. Studies showed, however, that it does nor prevent the arrival of lymph with a high toxin content. The best effect was produced when lympho- and hemosorption were combined under conditions of stimulation of lymph production and lymph drainage.
Subject(s)
Hemoperfusion , Lymph/physiology , Shock, Cardiogenic/therapy , Animals , Dogs , Female , Heart Function Tests , Hemodynamics , Humans , Methods , Shock, Cardiogenic/physiopathologySubject(s)
Lymph/physiology , Shock, Cardiogenic/therapy , Animals , Dogs , Drainage/methods , Female , Lymph/drug effects , Lymph/immunology , Male , Mannitol/pharmacology , Thoracic DuctABSTRACT
Study of the mechanisms of compensation derangement in cardiogenic shock in 70 anesthetized and nonanesthetized dogs irrespective of the type of its course showed that extracardiac shifts are of essential importance. In "fulgurating" shock, marked cardiac disorders may be aggravated by stimuli induced by hyperactive humoral and vascular (peripheral) reactions. In cardiogenic shock of a longer duration, the extracardiac mechanisms of decompensation are usually manifested by disorders of peripheral circulation associated with increasing hyporeactivity. With timely control the character of decompensation in cardiogenic shock may be prognosticated, which predetermines the principles of rational, pathogenetic therapy.
Subject(s)
Heart/physiopathology , Shock, Cardiogenic/etiology , Acidosis/physiopathology , Animals , Blood Circulation , Coronary Disease/physiopathology , Diuresis , Dogs , Epinephrine/blood , Hemodynamics , Models, Biological , Norepinephrine/blood , Oxygen/blood , Shock, Cardiogenic/classificationABSTRACT
In 30 experiments in order to specify the blood supply and conducting system in the dog heart, coronal arteries were injected with a contrasting mass that was followed by roentgenography and preparation of the coronal arteries. The topography and blood supply of the atrioventricular conducting system with application of prevital blood supply, and the left coronal artery is the main source of blood supply for all the parts of the cardiac atrioventricular conducting system.