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Vopr Virusol ; 28(4): 79-84, 1983.
Article in Russian | MEDLINE | ID: mdl-6314675

ABSTRACT

Combined virological, antigenic, electron microscopic, and molecular biologic study of the role of an oncovirus, herpes simplex type 2 virus (HSV-2), in the mechanisms of transformation of HSV-2-infected hamster cells was carried out. No expression of genetic information of the oncovirus could be detected. Cell transformation was shown to be associated with persistence and realization of HSV-2 genetic information in the transformed cells.


Subject(s)
Cell Transformation, Viral , Simplexvirus/genetics , Animals , Animals, Newborn , Antigens, Viral/analysis , Cell Line , Cricetinae , Cytotoxicity, Immunologic , DNA, Viral/genetics , Gene Expression Regulation , Immunization , Killer Cells, Natural/immunology , Nucleic Acid Hybridization , Retroviridae/genetics , Retroviridae/immunology , Simplexvirus/immunology , Spleen/immunology
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