[Effects of T-type calcium channel blockers on spontaneous meiotic maturation of mouse ovarian oocytes in vitro]. / Vlyv blokatoriv kal'tsievykh kanaliv t-typu na spontanne meiotychne dozrivannia ovarial'nykh ootsytiv myshei in vitro.

We studied the effects of blockers of the T-type Ca2+ channels on resumption of meiosis and spontaneous meiotic maturation of murine ovarial oocytes in vitro. We found that the efficiency of suppression of oocyte maturation by blockers of the Ca2+ channels increases in the following succession: amiloride hydrochloride, mebifradil, NiCl2. It is supposed that there is a possibility to use blockers of the T-type Ca2+ channels for creation of new combined intrauterine contraceptives.