ABSTRACT
CaCl2 and aconitic models of arrhythmias were reproduced in experiments with rats. Sodium salicylate was found to decrease the preventive effect of ecetylnovocainamidum and increased the effect of novocainamidum on ECG changes. Sodium salicylate diminished the preventive effect of acetyl-novocainamidum by elevating myocardial Na+ concentrations, favoured the decrease in myocardial K+ levels, eliminated the preventive effects of novocainamide and acetylnovocainamide by altering myocardial energy metabolism in CaCl2-induced arrhythmia and improved the preventive effect of acetyl-novocainamide on these parameters in aconitic arrhythmia.
Subject(s)
Acecainide/therapeutic use , Phenobarbital/therapeutic use , Procainamide/therapeutic use , Sodium Salicylate/therapeutic use , Aconitine , Animals , Arrhythmias, Cardiac/blood , Arrhythmias, Cardiac/chemically induced , Arrhythmias, Cardiac/drug therapy , Arrhythmias, Cardiac/physiopathology , Calcium Chloride , Drug Evaluation, Preclinical , Drug Interactions , Drug Therapy, Combination , Electrocardiography/drug effects , Female , Male , Rats , Rats, WistarABSTRACT
The effects of potassium malate and sodium succinate on the antiarrhythmic activity of novocainamide and acetylnovocainamide during modelling of chlor-calcium-induced arrhythmia as well as in disorders of cardiac rhythm during modelling of pituitrin-isadrine-induced myocardial infarction were studied. The metabolic agents were found to increase the effectiveness of acetylnovocainamide and the toxicity of novocainamide. To interpret the specific features of the mechanism of the anti-arrhythmic action of the compounds there was studied their ability to form complexes with components of biomembranes and ions of biometals.
Subject(s)
Anti-Arrhythmia Agents/therapeutic use , Malates/therapeutic use , Procainamide/analogs & derivatives , Procainamide/therapeutic use , Succinates/therapeutic use , Animals , Anti-Arrhythmia Agents/toxicity , Arrhythmias, Cardiac/chemically induced , Arrhythmias, Cardiac/drug therapy , Calcium Chloride , Drug Evaluation, Preclinical , Drug Synergism , Drug Therapy, Combination , Isoproterenol , Lethal Dose 50 , Myocardial Infarction/chemically induced , Myocardial Infarction/drug therapy , Pituitary Hormones, Posterior , Potassium/therapeutic use , Procainamide/toxicity , Rats , Rats, Inbred Strains , Succinic AcidABSTRACT
The antiarrhythmic activity of quinasopirine was studied in the experiments on rats with the use of models of calcium chloride- and aconitine-induced arrhythmias, disorders of cardiac rhythm in myocardial infarction produced by isadrine and pituitrin and also in the experiments on cats in arrhythmias caused by electric stimulation of the myocardium, postinfarction and reperfusion arrhythmias. Quinasopirine exhibits the antiarrhythmic effect being superior to that of anapriline and novocainamide in arrhythmias induced by calcium chloride and aconitine. In other types of the cardiac rhythm disorder its activity is comparable with that of ethmosine, obsidane and cordarone. Quinasopirine reduces automatism and contractile function of the myocardium.
