Subject(s)
Drug Delivery Systems/instrumentation , Nicotine/administration & dosage , Nicotinic Agonists/administration & dosage , Smoking Cessation/methods , Smoking Prevention , Tobacco Use Cessation Devices , Tobacco Use Disorder/drug therapy , Administration, Inhalation , Advertising , Consumer Product Safety , Drug Delivery Systems/standards , Electronics , Equipment Design , Humans , Marketing of Health Services , Nicotine/adverse effects , Nicotinic Agonists/adverse effects , Smoking/adverse effects , Tobacco Use Cessation Devices/adverse effects , Tobacco Use Cessation Devices/standards , Tobacco Use Disorder/diagnosis , Treatment OutcomeABSTRACT
One hundred and eighty-four patients aged 60-95 years who had ischemic heart disease (IHD) were examined. The serum levels of total cholesterol, triglycerides, high-density lipoproteins, low-density lipoproteins, apoA- and apoB-lipoproteins, calcium, phosphorus, alkaline phosphatase, etc. were measured on a Vitalab Flexor E. biochemical analyzer. The content of cytokines was determined by solid-phase immunoassay using the Protein contour test systems (State Research Institute of Particularly Pure Biologicals, Saint-Petersburg) on a Stat Fax photometer. There were pronounced changes in the cytokine spectrum in elderly and senile persons despite the fact that they had an adequate lipid spectrum. The increased levels of interleukin (IL)-1 beta and IL-6 suggest that there is an inflammatory reaction whereas those of tumor necrosis factor-alpha may be indicative of the body's autoimmune readiness. There was a high direct correlation of the content of apolipoproteins Apo-B1 and IL-6, as well as LP alpha and IL-6; ApoB1/Apo-A1 and IL-6. A high inverse correlation was found in the content of Apo-B1 and IL-6, which is a poor predictor in old age group patients. There was a mean correlation in the levels of apolipoproteins (B1 and B alpha) and the cytokines IL-1 beta, IL-4, IFN-gamma, TNF-alpha, and IFN-alpha; and there was a mean inverse correlation between the concentrations of apolipoproteins A1 and these cytokines.
Subject(s)
Interleukins/blood , Lipids/blood , Myocardial Ischemia/blood , Age Factors , Aged , Aged, 80 and over , Female , Humans , Interferons/blood , Male , Middle Aged , Sex Factors , Tumor Necrosis Factor-alpha/bloodABSTRACT
One hundred and seventy-eight patients aged 60-95 years who had ischemic heart disease (IHD) and osteoporosis (OP) were examined. The serum levels of total cholesterol, triglycerides, high-density lipoproteins, low-density lipoproteins, apoA- and apoB-lipoproteins, calcium, phosphorus, alkaline phosphatase, etc. were measured on a Vitalab Flexor E. biochemical analyzer. Bone metabolic markers, such as parathyroid hormone (PTH), osteocalcin (OC), calcitonin (CT), as well as C-terminal telopeptides (CTTP) resulting from collagen type I (in serum and urine) were determined on a Stat Fax photometer. There was a high direct correlation between the serum levels of OC, CTTP and those of calcium and an inverse correlation between the serum concentrations of alkaline phosphatase and PTH and those of calcium in the groups of geriatric patients with IHD and OP. The plots of the function approximating the relationship of the levels of total protein, total and ionized calcium, creatinine, and alkaline phosphatase to age could predict a adaptation potential reduction in these patient groups.
