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Activation of NF-κB in Schwann cells is dispensable for myelination in vivo.

Morton, Paul D; Dellarole, Anna; Theus, Michelle H; Walters, Winston M; Berge, Summer S; Bethea, John R.

J Neurosci ; 33(24): 9932-6, 2013 Jun 12.

Article in English | MEDLINE | ID: mdl-23761888

ABSTRACT

Peripheral myelination is a dynamic process orchestrated by axons and Schwann cells. Although the signaling mechanisms governing myelination are not fully understood, NF-κB activation in Schwann cells has been implicated as a key regulator in vitro. Using a mouse model, we show that nuclear factor κB activation in Schwann cells is not required for myelination in vivo.

Subject(s)

Myelin Sheath/metabolism , NF-kappa B/metabolism , Schwann Cells/enzymology , Animals , Animals, Newborn , Cells, Cultured , Cerebral Cortex/enzymology , Disease Models, Animal , Embryo, Mammalian , Gene Expression Regulation, Enzymologic/genetics , I-kappa B Kinase/deficiency , I-kappa B Kinase/genetics , Male , Mice , Mice, Inbred C57BL , Mice, Knockout , Myelin Basic Protein , Myelin P0 Protein/genetics , Myelin P0 Protein/metabolism , Nerve Growth Factors/metabolism , Proteins/genetics , Proteins/metabolism , RNA, Untranslated , S100 Calcium Binding Protein beta Subunit , S100 Proteins/metabolism , Schwann Cells/metabolism , Sciatic Nerve/metabolism , Sciatic Nerve/pathology , Sciatic Neuropathy/complications , Sciatic Neuropathy/pathology , Time Factors , Wallerian Degeneration/etiology , Wallerian Degeneration/pathology

ABSTRACT

Subject(s)

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