ABSTRACT
Conocer la historia, como en cualquier ámbito de la vida, es necesario para saber no sólo de dónde venimos sino comprender el porqué de la actualidad. También nos sirve de guía, como proyección hacia un futuro mucho mejor para nuestra profesión y, por ende, para las personas que podamos encontrar en el camino. Gracias a dicha historia, desde el COPTOA planteamos una necesidad de hablar de la terapia ocupacional a otros profesionales, a posibles beneficiarios, a los gestores de salud, educación o servicios sociales. O como dice el lema de este año de la Federación Mundial de Terapeutas Ocupacionales Unidad a través de la comunidad.(AU)
Knowing history, as in any area of life, is necessary to know not only where we come from but to understand why we are today. It also serves as a guide for us, as a projection towards a much better future for our profession and, therefore, for the people we may meet along the way. Thanks to this history, at COPTOA we raise the need to talk about occupational therapy to other professionals, to possible beneficiaries, to health, education or social services managers. Or as this year's motto of the World Federation of Occupational Therapists says, Unity through Community.(AU)
Subject(s)
Humans , Male , Female , Occupational Therapy/history , Social Participation , Community Participation , Societies , Specialty BoardsABSTRACT
Este documento pretende reflexionar la importancia de la comensalidad en nuestra sociedad en general y en personas diagnosticadas de enfermedad mental en particular. Además, nos brinda la oportunidad de valorar cómo el contexto interfiere, en este caso de manera positiva sobre la persona
This document aims to reflect the importance of commensality in our society in general and in people diagnosed with mental illness in particular. In addition, it gives us the opportunity to assess how the context interferes, in this case positively about the person
Subject(s)
Humans , Mental Disorders/psychology , Occupational Therapy/methods , Feeding Behavior , 24439 , Activities of Daily Living , Adaptation, Psychological , Disability Evaluation , Disabled Persons/psychology , Quality of LifeABSTRACT
En la siguiente recesión se presenta un artículo del antropólogo Gregory Bateson, que pretende mostrar cuán importante es tanto la modalidad del tratamiento como la capacidad de comunicación del profesional para incidir de manera positiva en el cambio intrínseco de la persona. A través de su lectura se pueden extraer otras reflexiones como son la identidad de la profesión, el nacimiento de la misma y su contexto, los paradigmas a lo largo de su historia, todos los cambios acontecido y sus causas y sobre todo el momento en el que estamos y hacia donde queremos dirigirnos sin perder la esencia de la terapia ocupacional, lo que nos diferencia del resto de profesionales, en vez de acercarnos cada vez más a ellos
In the following critical review, an opinion article by anthropologist Gregory Bateson, which aims to show how important is both the treatment modality and the professional's ability to communicate in a positive way in the intrinsic change of the person. Through its reading, other reflections can be detected, such as the identity of the profession, the birth of the profession and its context, the paradigms throughout its history, all the changes that have occurred and its causes and, above all, the moment in which that we are and where we are heading without losing the essence of occupational therapy, which differentiates us from other professionals, instead of getting closer and closer to them
Subject(s)
Humans , Communication , Physician-Patient Relations , Occupational Therapy/methods , Anthropology/methods , Mental HealthABSTRACT
No disponible
Subject(s)
Humans , Male , Middle Aged , Whipple Disease/drug therapy , Whipple Disease , Arthritis/drug therapy , Arthritis , Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use , Biopsy , Laparotomy , Tetracycline/therapeutic use , Spondylarthritis/complications , Spondylarthritis/drug therapy , Spondylarthritis , Gastroscopy/methodsABSTRACT
OBJECTIVE: Gain-of-function NLRP3 mutations cause cryopyrin-associated periodic syndrome (CAPS), with gene mosaicism playing a relevant role in the pathogenesis. This study was undertaken to characterize the genetic cause underlying late-onset but otherwise typical CAPS. METHODS: We studied a 64-year-old patient who presented with recurrent episodes of urticaria-like rash, fever, conjunctivitis, and oligoarthritis at age 56 years. DNA was extracted from both unfractionated blood and isolated leukocyte and CD34+ subpopulations. Genetic studies were performed using both the Sanger method of DNA sequencing and next-generation sequencing (NGS) methods. In vitro and ex vivo analyses were performed to determine the consequences that the presence of the variant have in the normal structure or function of the protein of the detected variant. RESULTS: NGS analyses revealed the novel p.Gln636Glu NLRP3 variant in unfractionated blood, with an allele frequency (18.4%) compatible with gene mosaicism. Sanger sequence chromatograms revealed a small peak corresponding to the variant allele. Amplicon-based deep sequencing revealed somatic NLRP3 mosaicism restricted to myeloid cells (31.8% in monocytes, 24.6% in neutrophils, and 11.2% in circulating CD34+ common myeloid progenitor cells) and its complete absence in lymphoid cells. Functional analyses confirmed the gain-of-function behavior of the gene variant and hyperactivity of the NLRP3 inflammasome in the patient. Treatment with anakinra resulted in good control of the disease. CONCLUSION: We identified the novel gain-of-function p.Gln636Glu NLRP3 mutation, which was detected as a somatic mutation restricted to myeloid cells, as the cause of late-onset but otherwise typical CAPS. Our results expand the diversity of CAPS toward milder phenotypes than previously reported, including those starting during adulthood.
