ABSTRACT
Several deep Greenland ice cores have been retrieved, however, capturing the Eemian period has been problematic due to stratigraphic disturbances in the ice. The new Greenland deep ice core from the NEEM site (77.45 °N, 51.06 °W, 2450 m.a.s.l) recovered a relatively complete Eemian record. Here we discuss the cosmogenic (10)Be isotope record from this core. The results show Eemian average (10)Be concentrations about 0.7 times lower than in the Holocene which suggests a warmer climate and approximately 65-90% higher precipitation in Northern Greenland compared to today. Effects of shorter solar variations on (10)Be concentration are smoothed out due to coarse time resolution, but occurrence of a solar maximum at 115.26-115.36 kyr BP is proposed. Relatively high (10)Be concentrations are found in the basal ice sections of the core which may originate from the glacial-interglacial transition and relate to a geomagnetic excursion about 200 kyr BP.
ABSTRACT
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are known to be potent inhibitors of new bone formation. We investigated whether NSAIDs given at surgery influence the long-term results after total hip arthroplasty (THA). PATIENTS AND METHODS: We performed a 10-year follow-up on 142 of 144 patients who had taken part in a randomized trial on the preventive effects of the NSAID ibuprofen on heterotopic ossification after THA. 96 patients were treated with ibuprofen: 48 for 1 week postoperatively, 48 for 2 weeks postoperatively, and 48 patients were not treated. RESULTS: 13 patients had been revised. All revisions except 1 belonged to groups treated with ibuprofen. The 10-year risk for revision was significantly higher in the ibuprofen-treated patients (p = 0.05). Eleven of the revisions occurred due to fractures of the femur (2) or aseptic loosening (9), reasons that may be attributed to negative effects of ibuprofen. For these patients, the 10-year risk for revision was not statistically significantly different between treated and untreated patients (p = 0.08). In addition to the revised patients, 94 other patients were alive at the 10-year follow-up and 84 underwent radiographic examination. 9 loose prostheses were found radiographically, but these were equally distributed between ibuprofen-treated and untreated hips. INTERPRETATION: The high proportion of revisions in the ibuprofen groups, in combination with clinical and experimental evidence of inhibitory effects on new bone formation of NSAIDs, warrants further investigation of the effects of these drugs on prosthetic fixation.
