Micafungin and a case of polymorphic ventricular tachycardia.

WHAT IS KNOWN AND OBJECTIVE: Although echinocandins are relatively safe antifungal drugs, cardiovascular toxicity is an emerging adverse event. This report reviews those side effects and describes a case of polymorphic ventricular tachycardia suggestive of torsades de pointes with micafungin. CASE DESCRIPTION: The patient was on micafungin for oesophageal candidiasis due to drug-drug interactions with fluconazole and amiodarone. WHAT IS NEW AND CONCLUSION: This is the first known case of polymorphic ventricular tachycardia with micafungin as the possible cause. Clinicians should be aware of this potential adverse event and monitor patients receiving concomitant drugs that can prolong QT interval.