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J Med Chem ; 47(4): 900-6, 2004 Feb 12.
Article in English | MEDLINE | ID: mdl-14761191

ABSTRACT

5(S)-Fluoro-N6-(iminoethyl)-l-lysine (14), an analogue of the potent, selective induced nitric oxide synthase (iNOS) inhibitor iminoethyl-l-lysine (1), was synthesized and found to be a selective iNOS inhibitor.


Subject(s)
Lysine/chemical synthesis , Nitric Oxide Synthase/antagonists & inhibitors , Crystallography, X-Ray , Isoenzymes/antagonists & inhibitors , Isoenzymes/chemistry , Lysine/analogs & derivatives , Lysine/chemistry , Models, Molecular , Nitric Oxide Synthase/chemistry , Nitric Oxide Synthase Type II
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