ABSTRACT
We examined the effect of bosentan, an ETA and ETB receptor antagonist, on EEG, an indicator of neuronal activity, in rats with experimentally induced cerebral ischemia-reperfusion. The rats were divided into three groups with seven rats in each group. Before the procedures, the EEGs of all rats were recorded for ten minutes. 30 mg/kg bosentan in 2 cc physiological serum was administered to the first group, and the second and third groups were injected with 2 cc physiological serum intraperitoneally. After the administration, the right and the left common carotid arteries of the animals in Groups 1 and 2 were clipped for 10 minutes using aneurysm clippings. The rats in the third group received only a subcutaneous incision. Ten minutes after the clips were removed in the first and second groups and after the incision in the third group, EEG recordings were repeated for 10 minutes. All the rats were decapitated and MDA values in the brain tissue were measured for evaluation of the efficiency of induced cerebral ischemia. Induced cerebral ischemia was performed effectively because the MDA levels in Groups 1 and 2 were elevated, compared to the levels in Group 3 (p<0.05). After the application of the Cerebral Ischemia-Reperfusion Technique, the EEG showed minimal slowing in the rats in Group 1, and generalized diffuse slowing in the rats in Group 2 compared to pre-ischemic findings. Bosentan may reduce the damage induced by ischemia on neuronal electrophysiology, likely through its vasodilation effect on cerebral vessels.
Subject(s)
Brain Ischemia/pathology , Reperfusion Injury/drug therapy , Sulfonamides/pharmacology , Animals , Antihypertensive Agents/pharmacology , Bosentan , Electroencephalography , Electrophysiological Phenomena , Female , Ischemia , Malondialdehyde/metabolism , Neurons/metabolism , Perfusion , Rats , Rats, WistarABSTRACT
Most cases of idiopathic Parkinson disease (IPD) are believed to be due to a combination of genetic and environmental factors. The purpose of this study is to investigate the relationship between toxocariasis and Parkinson disease (PD). Patients were selected from people who were admitted to the Movement Disorders Branch, Neurology Department of Elazig University Faculty of Medicine Elazig, Turkey. We studied specific IgG antibodies against Toxocara canis (T. canis) in 50 patients with idiopathic Parkinson and 50 healthy volunteers. We investigated the clinical history of three patients infected with T. canis. We also studied specific IgG antibodies against Toxoplasma gondii in these groups. Antibodies anti-Toxocara canis were found in 3 idiopathic PD (6%) (P = 0.121) and antibody titer was not found in control. A patient had history of the presence of dog in current dog ownership. We did not detect any statistically significant association between T. canis and IPD. But, we believe that further comprehensive studies are required for understanding whether there is a causal relation between toxocariasis and PD. We didn't find possible association between Toxoplasma gondii and IPD (P = 0.617).
Subject(s)
Antibodies, Helminth/blood , Parkinson Disease/blood , Parkinson Disease/parasitology , Toxocara canis , Toxocariasis/blood , Adult , Aged , Aged, 80 and over , Animals , Case-Control Studies , Dogs , Female , Humans , Immunoglobulin G/blood , Male , Middle Aged , Parkinson Disease/complications , Pets , Risk Factors , Seroepidemiologic Studies , Toxocariasis/complications , ToxoplasmaABSTRACT
STUDY DESIGN: A case report. OBJECTIVE: To present improvement of paraplegia due to spinal vascular malformation after delivery with no intervention. SUMMARY OF BACKGROUND DATA: Pregnancy has been reported rarely in patients with Klippel-Trenaunay syndrome (KTS). A combined case of spinal arteriovenous malformations (AVMs) within KTS has not been reported before. METHODS: A case report of KTS with paraplegia is presented and the pertinent literature is then reviewed. RESULTS: A pregnant woman who was diagnosed with KTS in childhood presented with newly developed paraplegia due to spinal AVMs. Magnetic resonance image showed a vascular malformation at the T9-T12 levels without evidence of spinal cord hemorrhage. Diagnostic angiography that was performed after delivery revealed a high-flow arteriovenous fistula with AVM. CONCLUSION: Pregnancy complicated by paraplegia is thought to be secondary to venous engorgement and to the resulting spinal cord ischemia in this case. Her neurological symptoms and signs gradually improved over the few days after cesarean delivery.
Subject(s)
Arteriovenous Malformations/complications , Klippel-Trenaunay-Weber Syndrome/complications , Paraplegia/etiology , Pregnancy Complications/etiology , Spinal Cord Ischemia/etiology , Adult , Arteriovenous Malformations/diagnostic imaging , Arteriovenous Malformations/genetics , Cesarean Section , Diagnosis, Differential , Fecal Incontinence/etiology , Female , Guillain-Barre Syndrome/diagnosis , Humans , Infant, Newborn , Magnetic Resonance Imaging , Pregnancy , Radiography , Spinal Cord/blood supply , Spinal Cord Ischemia/diagnosis , Thoracic Vertebrae , Urinary Incontinence/etiologyABSTRACT
Paroxysmal shooting or stabbing pain in the dermatomes of the nervus occipitalis major or nervus occipitalis minor is defined as occipital neuralgia. The initial cause of the neuralgia appears to be from inflammation, damage or irritation of these nerves. In this article, we present a patient with occipital neuralgia followed by thoracic herpes lesion.
Subject(s)
Herpes Zoster/diagnosis , Thorax , Trigeminal Neuralgia/complications , Diagnosis, Differential , Herpes Zoster/complications , Herpes Zoster/pathology , Humans , Male , Middle Aged , Severity of Illness IndexABSTRACT
We describe a 23 year old primigravid patient with severe preeclampsia complicated by posterior reversible encephalopathy syndrome (PRES), who presented with sensory and motor deficits and amnesia in the postpartum period Cranial magnetic resonance imaging (MRI) showed abnormal areas in the white matter of bilateral parieto-occipital lobes, indicating brain edema which disappeared completely on the follow-up scan taken four weeks after delivery together with complete symptom regression. The development of PRES in preeclampsia is discussed and the importance of prompt postpartum blood pressure control is emphasized.
