1.
Nervenarzt
; 65(2): 122-4, 1994 Feb.
Article
in German
| MEDLINE
| ID: mdl-8164764
ABSTRACT
A patient with focal epilepsy that was resistant to medical treatment received add-on therapy with vigabatrin. Six months after commencement of vigabatrin therapy, allergic vasculitis caused by vigabatrin was diagnosed. The patient displayed unilateral anterior ischaemic optic neuropathy with impairment of vision and concentric loss of visual field. The diagnosis was based on the lymphocyte transformation test and the clinical course. The allergic vasculitis was healed by cortisone therapy.
Subject(s)
Aminocaproates/adverse effects , Anticonvulsants/adverse effects , Drug Hypersensitivity/etiology , Epilepsies, Partial/drug therapy , Ischemia/chemically induced , Optic Nerve/blood supply , Optic Neuritis/chemically induced , Adult , Aminocaproates/therapeutic use , Anticonvulsants/therapeutic use , Dose-Response Relationship, Drug , Drug Administration Schedule , Epilepsy, Complex Partial/drug therapy , Epilepsy, Tonic-Clonic/drug therapy , Evoked Potentials, Visual/drug effects , Humans , Long-Term Care , Male , Reaction Time/drug effects , Vigabatrin
2.
