ABSTRACT
The toxicity of dioxydin and quinoxidine was studied in experiments on rats and mice given the drugs intravenously. The target organs for both drugs are the adrenals. The pathological process develops in their cortical layer and continues progressing after the drugs are discontinued. Quinoxidine appeared less toxic owing to which the pathological signs in the adrenals were reversible in the majority of animals given this drug in a dose of 100 mg/kg.
Subject(s)
Anti-Infective Agents/toxicity , Quinoxalines/toxicity , Adrenal Glands/drug effects , Adrenal Glands/pathology , Animals , Blood/drug effects , Body Weight/drug effects , Dose-Response Relationship, Drug , Male , Rats , Time FactorsABSTRACT
An original antibacterial drug dioxidine was subjected to toxicological studies during long-term parenteral administration of 0.5% solution to rats and guinea-pigs (in doses of 25-100 mg/kg). It was found that susceptibility to the drug correlated well with adrenal function. Guinea-pigs were more susceptible to dioxidine than rats. The data obtained indicate the existence of the interplay between non-specific resistance to toxic agents and glucocorticoid potency.
Subject(s)
Adrenal Glands/metabolism , Anti-Infective Agents/toxicity , Quinoxalines/toxicity , Adrenal Glands/drug effects , Animals , Anti-Infective Agents/metabolism , Dose-Response Relationship, Drug , Drug Tolerance , Guinea Pigs , Inactivation, Metabolic , Organ Size/drug effects , Quinoxalines/metabolism , RatsABSTRACT
The toxicity of bonaphthon was studied on laboratory animals of different species (mice, rats, guinea pigs, dogs) with its single and repeated (daily, for a space of 4 months) administration. It has been found that bonaphthon, with its single and repeated administration in doses much higher (by 16 to 32 times) than the ones recommended for human beings, is well tolerated not only by sexually mature, but also by immature animals (rats). Bonaphthon does not affect adversely the dynamic changes in the weight of the animals, nor does it have any effect on the diuresis, functional state of the gastro-intestinal tract and the cardiac activity. On its administration in toxic doses exceeding by 60 and more timesthe ones recommened for human beings the drug provokes flabbiness, bradycardia, a fall of arterial pressure and causes changes in the activity of nonspecific enzymatic systems of the liver. Among the test animals most sensitive to bonaphthon are mice.
Subject(s)
Antiviral Agents/toxicity , Naphthoquinones/toxicity , Animals , Antiviral Agents/administration & dosage , Blood Cells/drug effects , Blood Pressure/drug effects , Dogs , Drug Evaluation , Drug Tolerance , Female , Gastric Juice/metabolism , Gastric Mucosa/drug effects , Guinea Pigs , Male , Mice , Naphthoquinones/administration & dosage , RatsABSTRACT
When used in doses of 20-50 mg/kg on models of acute exudative and chronic propliferative inflammation in rats pyridinolcarbamate inhibited the development of an exudative reaction provoked by bradykinine and silver nitrate and did not influence the effects of histamine and dextran, nor the chronic proliferative inflammatory process. As concerns its antiexudative action pyridinolcarbamate is superior to butadion. The effect of the drug comes from its selective antibradykinine action.
