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J Biomed Opt ; 20(5): 051033, 2015 May.
Article in English | MEDLINE | ID: mdl-25692658

ABSTRACT

We present the results of a native fluorescence spectroscopy study of blood plasma of rats with experimental diabetes. It was shown that the fluorescence emission band shape at 320 nm excitation is the most indicative of hyperglycemia in the blood plasma samples. We provide the interpretation of this fact based on the changes in reduced nicotinamide adenine dinucleotide phosphate concentration due to glucose-related metabolic pathways and protein fluorescent cross-linking formation following nonenzymatic glycation.


Subject(s)
Diabetes Mellitus, Experimental/blood , Glucose/chemistry , Hyperglycemia/drug therapy , Plasma/chemistry , Spectrometry, Fluorescence/instrumentation , Spectrometry, Fluorescence/methods , Animals , Blood Glucose/chemistry , Body Weight , Cross-Linking Reagents/chemistry , Fluorescence , Gene Expression Regulation , Glycosylation , Hyperglycemia/blood , Male , Metabolic Networks and Pathways , NAD/chemistry , NADP/chemistry , Rats , Rats, Wistar
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