ABSTRACT
The aim of this study was describe effects of NonsteroidalAnti-inflammatory drug on prevalence of Helicobacter LikeOrganisms in gastric mucosa of Thoroughbreds horses. Werestudied 54 Thoroughbred horses in the national race TrackLa Rinconada Caracas-Venezuela. All equine were treatedby seven days with phenylbutazone at an intravenous doseof 4.4 mg/kg. All horses presented Equine gastric ulcer syndromeacute superficial gastritis (25/54), chronic gastritis witherosion focal (16/54), chronic gastritis with erosion focal andulcers (14/54) in the gastric in both regions mucosa squamousregion and glandular regions (fundus). Helicobacter Like Organismsinfection in the stomach was confirmed by Warthin-Starry (38/54). Gastric mucosa revealed numerous spiralshapedbacteria morphologically resembling Helicobacter LikeOrganisms in squamous regions, margo plicatus (20/38) andnumerous spiral-shaped bacteria in fundic glands (18/54). Inconclusion, we detected high presence of Helicobacter LikeOrganisms in the gastric mucosa of Thoroughbred horsestreatment with phenylbutazone.
Subject(s)
Animals , Anti-Inflammatory Agents , Horse Diseases/pathology , Gastritis/diagnosis , Gastritis/therapy , Gastritis/veterinary , Helicobacter Infections/pathology , Helicobacter Infections/veterinary , Horses/injuriesABSTRACT
El objetivo del estudio fue describir lesiones gástricas, hepáticas y renales en caballos Pura Sangre de Carreras enmarcadas en el síndrome ulceroso gástrico equino. Se trabajó con 30 ejemplares Pura Sangre de Carrera con historia de síndrome ulceroso gástrico y cólico recurrentes entre 2006 y 2007, en el Hipódromo «La Rinconada¼, Caracas, Venezuela. A los animales se les practicó la eutanasia y se colectó muestras de tejido gástrico, hepático y renal. Las muestras fueron procesadas por los métodos histológicos convencionales. En el estómago se observó mucosa intacta, pero con áreas de hiperemia y/o hiperqueratosis en 6 casos, pequeñas erosiones multifocales o úlceras en 30 casos, úlceras grandes multifocales con regiones extensas de erosión en 12 casos, y úlceras extensivas con áreas de exposición de la submucosa en 6 casos. La evaluación macroscópica del hígado evidenció icteria en 22 casos, así como hepatomegalia y patrón lobulillar en 18 casos. Los riñones mostraron congestión severa en todos los casos, pérdida de la relación córtico medular en 20 casos, necrosis cortical 18 casos, necrosis tubular aguda en todos los casos, necrosis papilar confluente en 6 casos y adherencia de la cápsula con fibroplasia intersticial en 4 casos. Las lesiones observadas en la mucosa gástrica, hígado y riñón estuvieron asociadas con terapéuticas prolongadas con antiinflamatorios no esteroideos.
The aim of this study was to describe gastric, hepatic, and renal lesions in Thoroughbred Racing horses associated to the equine gastric ulcer syndrome. Thirty horses with a history of gastric ulcer syndrome and recurrent colic during 2006 to 2007 at the Race Track «La Rinconada¼, Caracas, Venezuela were evaluated. Horses were euthanized and the necropsy was conducted. Tissue samples were collected from stomach, liver and kidney, and processed by conventional histological methods. In the stomach, the mucosa was intact but areas of hyperaemia and hyperkeratosis were observed in 6 cases, multifocal small erosions or ulcers in 6 cases, multifocal large ulcers with areas of extensive erosion in 12 cases and extensive areas of ulceration with exposure of the submucosa in 6 cases. The macroscopic evaluation of the liver showed evident hepatomegaly in 22 cases and lobular pattern in 18 cases. The kidneys showed severe congestion in all cases, loss of cortico-medullar ratio in 20 cases, cortical necrosis in 18 cases, acute tubular necrosis in all cases, papillary necrosis in 6 cases, and adherence of the capsule with interstitial fibroplasia in 4 cases. Lesions in the gastric mucosa, liver and kidney were associated with extended treatment with non-steroidal anti-inflammatory drugs.
Subject(s)
Animals , Horses , Liver/injuries , Gastritis , Kidney/injuries , Stomach UlcerABSTRACT
El presente estudio se realizó a partir de un caso de veramiento de delfín Stenella frontalis, hembra cría, reportado el 30/07/02 para Playa Dorada. Boca de Aroa, estado Falcón, Venezuela. Se mantuvo en una instalación marina por un período de tres días, tiempo durante el cual se le realizaron evaluaciones periódicas no invasivas y toma de datos morfométricos. Murió el 01/08/02 por paro cardiopulmonar. Se practicó estudio macroscópico postmortem, preservándose muestras en formoldehído al 10 por ciento para estudios histopatológicos de los siguientes órganos: corazón, pulmón, estómago, intestino grueso, hígado, riñón y lesiones de piel con capa grasa, fueron procesados en el laboratorio de Anatomía Patológica de la Universidad Central de Venezuela. Por los resultados obtenidos en el estudio microscópico se determinó que el individuo presentó una infección sistémica producto de una infección primaria por Herpesvirus spp., concominante con parasistismo secundario por Cyptosporidium spp., cuadro clínico que se vio complicado por las condiciones de estrés a las que se encontró sometido, producto del varamiento. Según la revisión bibliográfica realizada, la parasitosis por Cyptosporidium spp. no aparece reportada en Venezuela para el orden: Cetácea, lo cual se evidencia en la información recopilada acerca de parásitos estudiados para dicho orden. La osamenta se encuentra en Museo Científico de la Estación Biológica. Ranchi Grande-MARNR.
The present study was made, in the event of a young female dolphin of the specie Stenella frontalis, that was found stranded in Playa Dorada, in Boca de Aroa, in the Falcón State, the 07/30/02, in Venezuela. She was kept in a facility for a period of three days, during this period of time, she was evaluated periodically whit not invasive technique, and morphometry data recollection. She died the 08/01/02 due to respiratory arrest, which caused a cardiac arrest. A macroscopic postmortem study was made, taking samples and keeping them in formaldehyde 10% for histopathology study of the following organs: heart, lungs, stomach, large intestine, liver, kidney and lesions of the skin with a fat layer, they were processed in the Pathologic Anatomy laboratory of the Universidad Central de Venezuela. Because of the results of the microscopic study, it was determined that the dolphin presented a systemic infection, because of a primary infection by Herpesvirus spp., related with a secondary infection by Cryptosporidium spp., which was complicated with stress due to the beaching. The bibliographic revue reports that the parasitosis by Cryptosporidium spp. is not present to Venezuela in the Cetacean order, according to the compiled information about the studied parasites for this order. The skeleton is currently in the Scientific Museum of the Biological Station Rancho Grande - MARNR.
