Energy-restricted Central-European diet stimulates liver microsomal function in obese postmenopausal women - a randomized nutritional trial with a comparison to energy-restricted Mediterranean diet.

OBJECTIVE: Obesity and metabolic syndrome are risk factors for liver diseases like non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. A healthy food pattern is vital for managing these health problems, therefore, this study investigated how two calorie-restricted diets, the Central European diet (CED) and Mediterranean diet (MED), altered microsomal liver function in obese postmenopausal women with a risk of metabolic syndrome. PATIENTS AND METHODS: One-hundred-forty-four subjects were randomly assigned to the CED (n=72) or the MED (n=72) groups. A 13C-methacetin breath test was performed, before and after the intervention to assess CPDR (Cumulative Percentage Dose Recovery at 120 minutes of the test), TTP (Time to Peak - maximal momentary recovery of 13C) and Vmax (the maximum momentary 13C recovery). RESULTS: There was a statistically significant increase in TTP and Vmax in the CED group only (p=0.0159 and p=0.0498, respectively). Changes in CPDR and TTP due to intervention were significantly higher in the CED group than in the MED group (p=0.0440 and p=0.0115, respectively). CONCLUSIONS: This is the first study to document a stimulatory effect of the energy-restricted CED on liver microsomal function as compared to MED. The relatively short dietary intervention led to a significant difference in the CYP1A2 activity between groups. The trial was registered in the German Clinical Trials Register (DRKS-ID: DRKS00012958; URL: https://www.germanctr.de/).

[HYPERTENSION OF PREGNANCY ASSOCIATED WITH HYPERGOMOCYSTEINEMIA OF THE FIRST TRIMESTER OF PREGNANCY].

In this study, the association of high homocysteine concentrations (>10 µmol/L) of pregnant women with hypertensive disorders during pregnancy was studied, as well as other complications of pregnancy, such as loss of pregnancy in the first half, premature birth, intrauterine growth retardation, congenital malformations development of the fetus. A single-center prospective cohort study was conducted. Depending on the concentration of homocysteine detected by the immunoenzyme assay with monoclonal antibodies Homocysteine EIA ELISA (Axis-Shield Diagnostics Ltd, Scotland), for a period of up to 14 weeks, the subjects were divided into 2 groups: with high concentrations (>10 µmol/L) and normal levels (<10 µmol/L). We controlled complications of pregnancy: loss of pregnancy in the first half, premature birth, delayed fetal growth, congenital malformations of the fetus, gestational hypertension, mild and severe preeclampsia, eclampsia and HELLP syndrome. The results of the study showed that at a level of homocysteine I trimester >10 µmol/l spontaneous abortion, premature birth, gestational hypertension, mild preeclampsia develop more often. There were no differences in the groups for delaying intrauterine growth of the fetus, congenital malformations, severe preeclampsia.

[STATE OF ACTUAL FOOD ADULT WORKING POPULATION].

The aim of our study was to investigate the actual nutritional status of industrial workers; chemical composition, nutritional and energetic value of the daily food intake of 299 workers in western Kazakhstan. We used a food frequency questionnaire with 24-hour recall to get comprehensive information on the daily diet. Computer calculation was conducted for assessing dietary intake. We carried out calculation of daily food intake, nutrient chemical composition and calorific value by means of a computer program "Diet" (Astana, 2011). It was found that the consumptions of healthier foods is insufficient, food intake is not balanced, with a significant prevalence of protein and fat component. The specific recommendations were made in order to improve the dietary habits of workers.

[Morbidity and content of microelements in the blood of school children residing near chromium enterprises].

For the first time there was investigated the content of certain microelements in the blood of children of school age residing in the city of Aktobe (Kazakhstan), where the global giants, mining andprocessing chrome ore productions are located. There were determined blood levels of chromium, nickel, lead in children. There was shown the difference in the blood content of microelements in children, depending on region of residence and their correlation with the core indices of health and disease.

[Real nutrition of adults and children population of Aktyubinsk Region of Republic of Kazakhstan].

AIM: study real nutrition of adults and children population of Aktyubinsk Region of Republic of Kazakhstan. MATERIALS AND METHODS: 260 adults aged of 18-59 and 128 children aged of 10-17 years were under investigation. The adults were differentiated into three age groups: 18-29, 30-39 and 40-59 years. For studying real nutrition a daily energy need, protein content in rations, fats, carbohydrate and mineral substance - magnesium, iron, copper, zinc - were assesses by 24-hours nutrition reproduction method. Investigation was made by questionnaire of observed groups. RESULTS: according to power price and protein content the adults feeding is value and due to protein, content 10-12% from necessary daily energy is provided. In children and adolescents food ration of protein is 1.5 times below normal, real power price is 1.3 times below normal. Fats take a considerable part of food ration both in adults and in children and their amount is increased in 47.4% of men, 45.9% in women and about 50% in children instead of 30% of daily energy. Carbohydrates content in men and women is 1.4 times lower, they cover only 41,8% and 42.1% of energy while they must compose 56% from daily dose. Acute deficiency of carbohydrates intake is noticed in children in two times and power supply composes 39% against 55% of normal. Content mineral substances (magnesium, iron, copper and zinc) in rations adults and children reduced.

[Peculiarities of food status of children in different ecological conditions].

Features of the nutritional status of children living in different environmental conditions, are determined by such factors as the physical development of children, level of hemoglobin, serum iron and ferritin. More pronounced adverse effect on the nutritional status of children observed in the oil and gas processing regions and the Aral Sea region.

[The study of corrective role of plant--based drugs with antioxidant action in experimental intoxication with potassium dichromate].

The disturbance of the structure and function of pulmonary surfactant system (pSS) is an essential component of almost all pulmonary diseases. Chromium compounds have a damaging effect on the PSS, which contributes to the formation of nonspecific pulmonary diseases and a burden of chrome disease. The results showed that the oil of licorice (Glycyrrhiza glabra L) protects PSS in chronic chrome intoxication.

[Effect of domestic gas on morphological and functional state of parenchymatous organs in rats].

The work is devoted to a study of morphological and functional changes in liver and kidneys in the simulation of subacute toxic exposure of rats to domestic gas in the experiment. In the course of studies found that the subacute intoxication by domestic gas and its metabolites were shown to causes profound structural and metabolic lesions of the liver and kidneys that can progress to develop the chronic liver and kidney insufficiency.