Synthesis, structural characterization and influence on the phagocytic activity of human neutrophils of thiazoline and thiazine derivative ligands and their zinc(II) complexes.

The zinc(II) complexes dichloro[2-(3,4-dichlorophenyl)imino-kappaN-(2-thiazolin-kappaN-2-yl)thiazolidine]zinc(II) (1) and dichloro[2-(3,4-dichlorophenyl)imino-kappaN-(4H-5,6-dihydro-1,3-thiazin-kappaN-2-yl)tetrahydrothiazine]zinc(II) (2) have been isolated and characterized in the solid state by X-ray diffraction, elemental analysis and IR spectra. In both complexes, the environment around the zinc(II) ion may be described as a distorted tetrahedral geometry, with the metallic atom coordinated to two chlorine atoms [Zn-Cl(1)=2.218(1)A; Zn-Cl(2)=2.221(1)A], one imino nitrogen [Zn-N(3)=2.042(2)A] and one thiazoline nitrogen [Zn-N(1)=2.022(2)A] in complex 1 and to two chlorine atoms [Zn-Cl(1)=2.216(1)A; Zn-Cl(2)=2.192(1)A], one imino nitrogen [Zn-N(3)=2.045(2)A] and one thiazine nitrogen [Zn-N(1)=2.039(2)A] in complex 2. In addition, we also report in this study the crystal structure of the 2-(3,4-dichlorophenyl)imino-N-(2-thiazolin-2-yl)thiazolidine (TdTn) ligand as well as the synthesis and characterization by X-ray diffraction, (1)H and (13)C NMR spectra, elemental analysis, IR and electronic spectra of the 2-(3,4-dichlorophenyl)imino-N-(4H-5,6-dihydro-1,3-thiazin-2-yl)tetrahydrothiazine (TzTz) ligand. Besides, we study the phagocytic function in humans neutrophils treated with each complex and ligand aforementioned.

Synthesis and physic-chemical properties of a copper(II) complex with 2-(2-pyridyl)iminotetrahydro-1,3-thiazine hydrochloride-water (1/2) (PyTzHCl.2H2O). Crystal structure of PyTz and [[CuCl(PyTz)]2(mu-Cl)2].

The synthesis of 2-(2-pyridyl)iminotetrahydro-1,3-thiazine (PyTz) has been carried out, as well as the determination of its X-ray crystal structure, together with the coordination behaviour and equilibra study of PyTzHCl.2H2O with copper(II) in aqueous solution at 298 K and 0.1 M ionic strength in NaClO4. The formation constants are determined and discussed in terms of the characteristics of the ligand. The compound Di-mu-chloro-bis[chloro[2-(2-pyrydil-kappaN)amino-5,6-dihydro-4H-1,3-thiazine-kappaN]copper] has been isolated and its crystal and molecular structure determined by X-ray analysis. The structure consists of dimeric molecules [Cu2Cl4L2], in which copper ions are bridged by two chloro ligands. The geometry about each copper approximates to a distorted square pyramid with the bridging ligands occupying apical and equatorial sites of each copper ion, while the PyTz ligand and the remaining chloride ion are located in an equatorial plane. The compound was also characterized through elemental analysis, magnetic susceptibility, electron paramagnetic resonance, and electronic and infrared spectroscopies.

Synthesis and characterization of a new cobalt(II) complex with 2-(2-pyridyl)imino-N-(2-thiazolin-2-yl)thiazolidine (PyTT).

The compound aquanitrate-small ka, CyrillicObis[2-(2-pyridy)-imin-small ka, CyrillicN-N-(2-thiazin-small ka, CyrillicN-2-y)thiazidine]cbat() nitrate has been isolated and characterized by single crystal X-ray diffraction, IR spectroscopy, UV-Vis-NIR diffuse reflectance and magnetic susceptibility measurements. The environment around the cobalt atom may be described as a distorted octahedral geometry with the ligand-metal-ligand bite angles varying between 84.07(8)( degrees ) and 98.66(8)( degrees ).The metallic atom is coordinated to two thiazoline nitrogens [av. Co-N =2.067 A], two imino nitrogens [av. Co-N =2.122 A], one oxygen atom of the nitrate group monodentate [Co-O(1)= 2.249(2) A] and the oxygen atom of the water molecule [Co-O(IW)= 2.105(2) A]. Electronic UV-Vis-NIR spectral data and the calculated magnetic moment are indicative of octahedral Co(ll) complexes. In the same way as other PyTT complexes, the organic moiety preserves the imino-thiazolidine form detected in the structure of PyTT.