Osteopatia hipertrófica associada à metástase intratorácica de carcinoma mamário em cadela: relato de caso / Osteopathy hypertrophic associated intrathoracic metastasis of breast carcinoma in a bitch: a case report

A osteopatia (ou osteoartropatia) hipertrófica é um distúrbio de osteoprodução generalizada do periósteo que acomete os ossos longos, sendo geralmente secundária a alguma doença intratorácica, como doença cardiopulmonar ou neoplasia. A osteopatia hipertrófica pulmonar é uma doença incomum e que tem sido descrita em várias espécies, com maior frequência em humanos e cães. Os cães apresentam como sinais clínicos, claudicação, andar relutante, febre, letargia e anorexia. Tumefações dolorosas, de grau leve a moderado, principalmente nas metáfises distais do rádio e da ulna. O exame radiográfico é o método auxiliar mais importante para o estabelecimento do diagnóstico de osteopatia hipertrófica. O presente trabalho tem como objetivo relatar um caso de osteopatia hipertrófica associado à metástase pulmonar de carcinoma mamário. A toracoscopia realizada serviu de auxílio no diagnóstico, além de conduzir na escolha do tratamento.(AU)

Hypertrophic osteopathy is a disorder of production of the periosteum that affects the long bones, usually secondary to some intrathoracic pathology, such as cancer (neoplasms) or cardiopulmonary disease. Hypertrophic pulmonary osteoarthropathy is an uncommon disease that described in many species, frequently reported in humans and dogs. Clinical signs in dogs are claudication, reluctant to walk, fever, lethargy and anorexia. Painful swellings, mild to moderate, mainly in the metaphyseal distal radius and ulna. Radiographic examination is the most important method for the diagnosis of hypertrophic osteopathy. This study aims to report a case of hypertrophic osteopathy associated with lung metastasis of breast carcinoma. Addition to the uniqueness of the case described, thoracoscopy proved to be an effective imaging test to help design strategies of diagnostic and surgical treatment.(AU)

Osteopatia hipertrófica associada à metástase intratorácica de carcinoma mamário em cadela: relato de caso / Osteopathy hypertrophic associated intrathoracic metastasis of breast carcinoma in a bitch: a case report

A osteopatia (ou osteoartropatia) hipertrófica é um distúrbio de osteoprodução generalizada do periósteo que acomete os ossos longos, sendo geralmente secundária a alguma doença intratorácica, como doença cardiopulmonar ou neoplasia. A osteopatia hipertrófica pulmonar é uma doença incomum e que tem sido descrita em várias espécies, com maior frequência em humanos e cães. Os cães apresentam como sinais clínicos, claudicação, andar relutante, febre, letargia e anorexia. Tumefações dolorosas, de grau leve a moderado, principalmente nas metáfises distais do rádio e da ulna. O exame radiográfico é o método auxiliar mais importante para o estabelecimento do diagnóstico de osteopatia hipertrófica. O presente trabalho tem como objetivo relatar um caso de osteopatia hipertrófica associado à metástase pulmonar de carcinoma mamário. A toracoscopia realizada serviu de auxílio no diagnóstico, além de conduzir na escolha do tratamento.

Hypertrophic osteopathy is a disorder of production of the periosteum that affects the long bones, usually secondary to some intrathoracic pathology, such as cancer (neoplasms) or cardiopulmonary disease. Hypertrophic pulmonary osteoarthropathy is an uncommon disease that described in many species, frequently reported in humans and dogs. Clinical signs in dogs are claudication, reluctant to walk, fever, lethargy and anorexia. Painful swellings, mild to moderate, mainly in the metaphyseal distal radius and ulna. Radiographic examination is the most important method for the diagnosis of hypertrophic osteopathy. This study aims to report a case of hypertrophic osteopathy associated with lung metastasis of breast carcinoma. Addition to the uniqueness of the case described, thoracoscopy proved to be an effective imaging test to help design strategies of diagnostic and surgical treatment.

Extradural anesthesia with lidocaine combined with fentanyl or methadone to ovariohisterectomy in dogs.

PURPOSE: To compare the cardiopulmonary effects and the quality of anesthesia of the extradural lidocaine in combination with fentanyl or morphine in bitches undergoing ovariohysterectomy. METHODS: Sixteen female dogs, were sedated with intramuscular acepromazine (0.05 mg kg-1), followed by anesthetic induction with intravenous propofol (4 mg kg-1), to perform the lumbosacral puncture. The animals were randomly assigned to two treatments: T-F (n=8) extradural administration of fentanyl (5 µg kg-1), T-M (n=8) extradural administration of methadone (0.3mg kg-1). In both treatment groups, opioids were combined with lidocaine, in order to make up a final volume of 0.4 mL kg-1. Heart rate (HR), respiratory rate (RR), systolic arterial blood pressure (SABP), intra-operative anesthetic supplementation, blood gases and adverse effects were investigated. RESULTS: HR, arterial pH and blood gases did not differ between treatments at any time point. RR and SABP decreased after epidural anesthesia, but the values were in terms of the physiological range of dogs. Intra-operative anesthetic supplementation was required in 50% and 62.5% of the fentanyl and methadone treated dogs, respectively. CONCLUSION: The extradural lidocaine in combination with fentanyl or morphine allowed cardiopulmonary stability, however sufficient sensitive blockade was not provided in 100% of the dogs.

Extradural anesthesia with lidocaine combined with fentanyl or methadone to ovariohisterectomy in dogs

PURPOSE: To compare the cardiopulmonary effects and the quality of anesthesia of the extradural lidocaine in combination with fentanyl or morphine in bitches undergoing ovariohysterectomy. METHODS: Sixteen female dogs, were sedated with intramuscular acepromazine (0.05mg kg-1), followed by anesthetic induction with intravenous propofol (4mg kg-1), to perform the lumbosacral puncture. The animals were randomly assigned to two treatments: T-F (n=8) extradural administration of fentanyl (5µg kg-1), T-M (n=8) extradural administration of methadone (0.3mg kg-1). In both treatment groups, opioids were combined with lidocaine, in order to make up a final volume of 0.4mL kg-1. Heart rate (HR), respiratory rate (RR), systolic arterial blood pressure (SABP), intra-operative anesthetic supplementation, blood gases and adverse effects were investigated. RESULTS: HR, arterial pH and blood gases did not differ between treatments at any time point. RR and SABP decreased after epidural anesthesia, but the values were in terms of the physiological range of dogs. Intra-operative anesthetic supplementation was required in 50% and 62.5% of the fentanyl and methadone treated dogs, respectively. CONCLUSION: The extradural lidocaine in combination with fentanyl or morphine allowed cardiopulmonary stability, however sufficient sensitive blockade was not provided in 100% of the dogs.(AU)

Extradural anesthesia with lidocaine combined with fentanyl or methadone to ovariohisterectomy in dogs

PURPOSE: To compare the cardiopulmonary effects and the quality of anesthesia of the extradural lidocaine in combination with fentanyl or morphine in bitches undergoing ovariohysterectomy. METHODS: Sixteen female dogs, were sedated with intramuscular acepromazine (0.05mg kg-1), followed by anesthetic induction with intravenous propofol (4mg kg-1), to perform the lumbosacral puncture. The animals were randomly assigned to two treatments: T-F (n=8) extradural administration of fentanyl (5µg kg-1), T-M (n=8) extradural administration of methadone (0.3mg kg-1). In both treatment groups, opioids were combined with lidocaine, in order to make up a final volume of 0.4mL kg-1. Heart rate (HR), respiratory rate (RR), systolic arterial blood pressure (SABP), intra-operative anesthetic supplementation, blood gases and adverse effects were investigated. RESULTS: HR, arterial pH and blood gases did not differ between treatments at any time point. RR and SABP decreased after epidural anesthesia, but the values were in terms of the physiological range of dogs. Intra-operative anesthetic supplementation was required in 50% and 62.5% of the fentanyl and methadone treated dogs, respectively. CONCLUSION: The extradural lidocaine in combination with fentanyl or morphine allowed cardiopulmonary stability, however sufficient sensitive blockade was not provided in 100% of the dogs.

Analgesia e ação antiinflamatória da Arnica montana 12CH comparativamente ao cetoprofeno em cães / Analgesic and anti-inflammatory effects of Arnica montana 12CH in comparison with ketoprofen in dogs

Objetivou-se avaliar os efeitos analgésico e antiinflamatório da Arnica montana 12CH comparativamente ao cetoprofeno em cadelas submetidas à ovariossalpingohisterectomia (OSH). Foram avaliadas 16 cadelas, distribuídas aleatoriamente em dois grupos de oito animais cada, tratados por via oral com 1mg kg-1 de cetoprofeno (TC) e com cinco glóbulos de Arnica montana 12CH (TA). Decorridos 60 minutos, os animais foram tranquilizados com acepromazina (0,05mg kg-1, IV), seguindo-se indução e manutenção anestésica com propofol (5mg kg-1, IV) e isofluorano, respectivamente. Foram mensurados: frequência cardíaca, frequência respiratória, pressão arterial sistólica, concentração final expirada de dióxido de carbono, concentração final expirada de isofluorano, variáveis hemogasométricas, concentração sérica de cortisol, grau de analgesia e de inflamação. Em casos de analgesia insuficiente, foi realizada suplementação com morfina (0,5mg kg-1, IM). A estatística foi realizada com ANOVA e teste de Tukey (P<0,05). Estabilidade cardiorrespiratória foi observada em ambos os tratamentos durante a OSH. Não houve diferença entre os tratamentos em relação ao grau de analgesia e de inflamação. Analgesia de resgate foi necessária em dois animais de cada grupo. Conclui-se que a Arnica montana 12 CH confere efeitos analgésico e antiinflamatório semelhantes aos do cetoprofeno, sendo uma opção segura e efetiva para cadelas submetidas à OSH.

This study aimed to evaluate the analgesic and anti-inflammatory effects of Arnica montana 12CH comparatively to ketoprofen in dogs undergoing ovariohysterectomy. Sixteen female dogs were randomly distributed in two groups of eight animals and received 1mg kg-1 of ketoprofen (TC) and 5 globules of Arnica montana 12CH (TA) by oral route. After 60 minutes, the dogs were sedated with acepromazine (0.05mg kg-1, IV), followed by anesthetic induction with propofol (5mg kg-1 IV) and maintained with isoflurane. Heart rate, respiratory rate, systolic blood pressure, arterial blood gases, serum cortisol concentration and degree of analgesia and inflammation were measured. Additional morphine (0.5mg kg-1IM) was given when the analgesia was insufficient. Statistical analyses were performed by ANOVA and Tukey tests (P<0.05). Cardiopulmonary stability was observed in both treatments during the surgery. The degree of analgesia and inflammation did not differ between groups. Rescue analgesia was administered to two dogs from each group. It was concluded that Arnica montana 12CH provides similar analgesic and anti-inflammatory effects when compared with ketoprofen, suggesting that this treatment is a safe and effective option to dogs undergoing ovariohysterectomy.