ABSTRACT
We describe nontuberculous mycobacteria (NTM) infections during 2012-2020 associated with health care and aesthetic procedures in France. We obtained epidemiologic data from the national early warning response system for healtcare-associated infections and data on NTM isolates from the National Reference Center for Mycobacteria. We compared clinical and environmental isolates by using whole-genome sequencing. The 85 original cases were reported after surgery (48, 56%), other invasive procedures (28, 33%) and other procedures (9, 11%). NTM isolates belonged to rapidly growing (73, 86%) and slowly growing (10, 12%) species; in 2 cases, the species was not identified. We performed environmental investigations for 38 (45%) cases; results for 12 (32%) were positive for the same NTM species as for the infection. In 10 cases that had environmental and clinical samples whose genomes were similar, the infection source was probably the water used in the procedures. NTM infections could be preventable by using sterile water in all invasive procedures.
Subject(s)
Mycobacterium Infections, Nontuberculous , Nontuberculous Mycobacteria , Delivery of Health Care , Esthetics , France/epidemiology , Humans , Mycobacterium Infections, Nontuberculous/epidemiology , Mycobacterium Infections, Nontuberculous/microbiologyABSTRACT
We investigated the source of infection in a patient who developed acute hepatitis C virus infection after cardiothoracic surgery. A healthcare worker was found to be infected with hepatitis C virus, and molecular analysis indicated the strain was similar to that found in the patient. The exact mode of transmission was not identified; however, atopic eczema on the healthcare worker's hands may have contributed to the transmission.
Subject(s)
Hepatitis C/transmission , Infectious Disease Transmission, Professional-to-Patient , Acute Disease , Coronary Artery Bypass , Genotype , Hepacivirus/genetics , Hepatitis C/virology , Humans , Male , Middle Aged , Postoperative ComplicationsABSTRACT
VEB-1 extended-spectrum beta-lactamase-producing Acinetobacter baumannii was responsible for an outbreak in hospitals in France. A national alert was triggered in September 2003 when 4 hospitals reported clusters of A. baumannii infection with similar susceptibility profiles. Case definitions and laboratory guidelines were disseminated, and prospective surveillance was implemented; strains were sent to a single laboratory for characterization and typing. From April 2003 through June 2004, 53 hospitals reported 290 cases of A. baumannii infection or colonization; 275 isolates were bla(VEB-1)-positive and clonally related. Cases were first reported in 5 districts of northern France, then in 10 other districts in 4 regions. Within a region, interhospital spread was associated with patient transfer. In northern France, investigation and control measures led to a reduction of reported cases after January 2004. The national alert enabled early control of new clusters, demonstrating the usefulness of early warning about antimicrobial drug resist.
Subject(s)
Acinetobacter Infections/epidemiology , Acinetobacter baumannii/drug effects , Cross Infection/epidemiology , Disease Outbreaks , beta-Lactam Resistance , beta-Lactamases/metabolism , Acinetobacter Infections/microbiology , Acinetobacter baumannii/classification , Acinetobacter baumannii/enzymology , Acinetobacter baumannii/genetics , Cross Infection/microbiology , Escherichia coli Proteins , France/epidemiology , Hospitals , Humans , Infection Control/methods , Microbial Sensitivity Tests , Population SurveillanceABSTRACT
The possible transmission of pathogens to 236 persons exposed to an endoscope processed in a flawed automated endoscope washer-disinfector in a gastrointestinal endoscopy unit was investigated. During 6 months, 197 patients (83.5%) were followed up, and no cases of acute human immunodeficiency virus, hepatitis C virus, or hepatitis B virus infection were observed. This event created the conditions for improvements in safety procedures.
