Dramatic Increase in Incidence of Ulcerative Colitis and Crohn's Disease (1988-2011): A Population-Based Study of French Adolescents.

OBJECTIVES: Few data are available to describe the changes in incidence of pediatric-onset inflammatory bowel disease (IBD). The aim of this study was to describe changes in incidence and phenotypic presentation of pediatric-onset IBD in northern France during a 24-year period. METHODS: Pediatric-onset IBD (<17 years) was issued from a population-based IBD study in France between 1988 and 2011. Age groups and digestive location were defined according to the Paris classification. RESULTS: 1,350 incident cases were recorded (8.3% of all IBD) including 990 Crohn's disease (CD), 326 ulcerative colitis (UC) and 34 IBD unclassified (IBDU). Median age at diagnosis was similar in CD (14.4 years (Q1=11.8-Q3=16.0)) and UC (14.0 years (11.0-16.0)) and did not change over time. There were significantly more males with CD (females/males=0.82) than UC (females/males=1.25) (P=0.0042). Median time between onset of symptoms and IBD diagnosis was consistently 3 months (1-6). Mean incidence was 4.4/105 for IBD overall (3.2 for CD, 1.1 for UC and 0.1 for IBDU). From 1988-1990 to 2009-2011, a dramatic increase in incidences of both CD and UC were observed in adolescents (10-16 years): for CD from 4.2 to 9.5/105 (+126%; P<0.001) and for UC, from 1.6 to 4.1/105 (+156%; P<0.001). No modification in age or location at diagnosis was observed in either CD or UC. CONCLUSIONS: In this population-based study, CD and UC incidences increased dramatically in adolescents across a 24-year span, suggesting that one or more strong environmental factors may predispose this population to IBD.

Spatiotemporal gait parameters during dual task walking in need of care elderly and young adults. A cross-sectional study.

BACKGROUND: Up to now there have only been marginal data in the elderly in need of care regarding spatiotemporal gait parameters during single (ST) and dual tasking (DT). AIM: The aim of this study was to allocate data for gait speed, cadence and stride length cycle variability in the elderly in need of care and in young adults during ST and DT, to compare the two groups and to demonstrate the impact of ST and DT on gait parameters. MATERIAL AND METHODS: This cross-sectional study investigated a group of 16 young healthy adults (mean age 23.0 ± 2.5 years) and a group of 16 elderly persons in need of care (mean age 85.5 ± 0.6 years). The RehaWatch system was used to collect the spatiotemporal gait parameters cadence, speed and stride length. The participants completed four different measurements during normal walking and fast walking during ST and DT over a walking distance of 20 m. The Wilcoxon rank sum test and Whitney-U test were used for statistical analysis. RESULTS: Gait speed (ST and DT: p < 0.001), cadence (ST and DT: p < 0.001) and gait variability (ST: p = 0.007, DT: p = 0.003) were significantly reduced in the elderly in need of care group compared to the young group. The gait speed in the elderly in need of care group decreased from normal to fast walking (ST = - 2.8%, DT = - 12.2%) compared to the young group (ST = 31.5%, DT = 25.2%). CONCLUSION: The results of this study are comparable with the results of existing studies, which investigated falling and non-falling participants. Elderly people in need of care cannot increase the normal gait speed.

[A double-faced myocarditis: Whipple's disease or sarcoidosis?]. / Une myocardite à deux visages : maladie de Whipple ou sarcoïdose?

INTRODUCTION: Whipple's disease is a systemic infection that may mimic sarcoidosis in its initial presentation. The heart involvement is not uncommon and consists generally in an endocarditis. Myocarditis is less common and is usually accompanied by impairment of heart conduction. CASE REPORT: We report a 56-year-old man with Whipple's disease associated with a myocarditis, initially diagnosed as having a sarcoidosis with cardiac injury. The contribution of the histology and molecular biology on intestinal sampling made it possible to rectify the diagnosis. CONCLUSION: The diagnosis of Whipple's disease should be considered in the presence of a systemic granulomatosis with or without heart involvement. Early diagnosis is important because of effectiveness of antibiotic therapy.

[Uncommon manifestation revealing sarcoidosis]. / Un mode de révélation inhabituel de la sarcoïdose.

INTRODUCTION: Bilateral hilar lymphadenopathy, with or without lung parenchymal infiltrates, is the most common radiographic finding in patients with sarcoidosis. Atypical pulmonary findings have been uncommonly reported and include multiple large lung nodules, cavitation, lobar collapse, pleural effusions or pneumothorax. OBSERVATION: We report a 21-year-old non caucasian patient who presented with pulmonary nodular infiltration and sinonasal involvement revealing sarcoidosis. Thoracic and sinus computed tomographic scan showed both multiple excavated large lung nodules and micronodules, hilar lymphadenopathy and sinus thickening. Laboratory studies disclosed elevated angiotensin converting enzyme serum level (120UI/L). Outcome was favorable after institution of corticosteroids (at an initial dose of prednisone of 1mg/kg/day); at eight-month-follow-up, the patient was asymptomatic, while receiving prednisone 22.5mg/day. CONCLUSION: In patients exhibiting unusual pulmonary manifestations, diagnosis of sarcoidosis relies on compatible clinical signs, evidence of non-caseating granulomas, and exclusion of underlying conditions including infections, malignancy and other granulomatous diseases (Wegener disease, pneumoconiosis).

[Mesenteric artery involvement in giant cell arteritis: two cases and literature review]. / Artérite inflammatoire mésentérique au cours de la maladie de Horton : à propos de deux observations et revue de la littérature.

INTRODUCTION: Mesenteric involvement has been rarely reported in giant cell arteritis (GCA). Our literature search using the Medline database (1966-2008), reviewing all articles in English and French languages identified only 31 cases of mesenteric ischemia related to GCA. We report two additional cases. CASE REPORTS: We report two men with GCA. At diagnosis of GCA-associated mesenteric involvement, patients exhibited: fever/fatigue (n=2), abdominal complaints (n=1), clinical signs of GCA (n=1). In both patients, abdominal CT-scan showed circumferential halo around the superior mesenteric artery. At systematic follow-up, CT-scan revealed improvement of mesenteric damage in both patients. CONCLUSION: Our study indicates that CT-scan is a useful technique in diagnosis of GCA-associated mesenteric involvement. Furthermore, we suggest that CT-scan may also be helpful in both the monitoring and the medical management of GCA-related mesenteric artery involvement.

[Cutaneous leishmaniasis in polymyositis]. / Leishmaniose cutanée au cours d'une polymyosite.

INTRODUCTION: The prevalence of cutaneous leishmaniasis is increasing, especially in immunocompromized subjects. CASE RECORD: We report a case of particular interest, where a patient with steroid refractory polymyositis developed cutaneous leishmaniasis. Clinical outcome was favorable after institution of intralesional antimony therapy. DISCUSSION: Cutaneous leishmaniasis is still recognized to be an opportunistic infection. Its frequency is indeed higher in immunocompromized subjects, mainly HIV-infected patients. In our patient, both polymyositis and steroid therapy were predisposing factors of cutaneous leishmaniasis onset; prednisone therapy has been postulated to be associated with immune dysfunction leading to: reduced blood T cells' levels (CD4 et CD8) as well as decreased cytokine synthesis (e.g. interferon gamma).

[Early detection of visual disorders by pediatricians]. / Dépistage précoce des troubles visuels en cabinet de pédiatrie.

A group of pediatricians from Northern France whose aim was to develop research projects in ambulatory pediatrics, elaborated a method of rapid assessment of visual acuity that can be applied by the pediatrician in the consulting room. This test was included in the routine examination of children between the age of 2 1/2 and 4, the age of 3 years being the most appropriate. The method is simple, reliable, reproducible and cheap since it is part of the pediatrician's consultation. Visual defects can be detected at an early stage and children can be treated when they still have a maximum chance of being cured. Thus it appears a useful test in terms of prevention of disease and public health.

Dental hygienists' knowledge and opinions about fluorides and fluoridation.

This article reports results of a study of 563 practicing Minnesota and Wisconsin dental hygienists' knowledge and opinions about fluorides and water fluoridation. Two independent samples were selected randomly from the populations of licensed dental hygienists residing in the two states. Data were collected using a pretested, 42-item, mailed questionnaire. An 84 percent response was achieved with two followup reminders. These data provide baseline information about the caries prevention knowledge and attitudes of practicing dental hygienists in two states. Respondents from both states held similar levels of knowledge about fluorides and opinions about decision making on fluoridation. Fluoride topics, especially water fluoridation, were not receiving high priority in patient education, although nearly all believed that dental hygienists should promote water fluoridation actively. Two-thirds of respondents from both states believed fluoridation decisions should be made by health authorities, rather than by elected officials or through public vote. Greater attention to patient education about fluoride and community water fluoridation is needed by dental hygienists.

[Optochiasmatic tuberculoma and MRI. 2 cases]. / Tuberculomes opto-chiasmatiques et IRM. Deux observations.

Two cases are reported of optochiasmatic tuberculoma, an exceptional complication difficult to diagnose in the absence of any tuberculous context. Although diagnosis of the optochiasmatic occupying process is simple by scan or NMR imaging, it is generally difficult to identify the chiasma in a process of this type. It is therefore impossible to recognize the two forms of these tuberculomas: intra- and peri-chiasmatic histologic types, and yet these have an incidence on therapy and prognosis. Surgical exploration is justified when the diagnosis remains in doubt or when the functional prognosis is implicated.

Dental hygienists' knowledge, opinions, and use of pit and fissure sealants: a comparison of two states.

This article reports results of a study of 563 practicing Minnesota and Wisconsin dental hygienists' knowledge, opinions, and use of pit and fissure sealants. The study was carried out six months prior to the 1983 NIH Consensus Development Conference on Dental Sealants in the Prevention of Tooth Decay. It therefore provides baseline information for two states prior to the initiation of widespread public information about the positive value of sealants that occurred as a result of that conference. Such baseline information is relevant for future studies of the diffusion of adoption of this caries-preventive technology by dental hygienists. Two independent samples were selected randomly from the populations of licensed dental hygienists residing in the two states. Data were collected using a 42-item mailed questionnaire, with an 84 percent response. Data were analyzed for both interstate and intrastate comparisons. Respondents were generally knowledgeable and had favorable opinions about sealants, although they had low levels of training in their use. Sealants were being used in 54 percent of the offices in which respondents practiced, with the dentist placing them most often. Among hygienists who applied sealants at all, more than two-thirds did so three or fewer times per week. Eighty-four percent indicated they would like to apply sealants more often. The most frequent reasons given for nonuse were lack of acceptance by the dentist-employer and nondelegation.