ABSTRACT
Primary non-Hodgkin's lymphomas (NHL) of the breast represent less than 3% of extranodal NHL; in comparison to extranodal NHL at other sites, they are characterized by rapid progression and worse prognosis. We report a case of primary NHL of the breast treated, after surgery, with a sequential combination of chemotherapy and radiotherapy. Literature data suggest that the most important factors in therapeutic decisions making are the initial stage of the disease and the histological subtype.
Subject(s)
Breast Neoplasms/surgery , Lymphoma, Non-Hodgkin/surgery , Adult , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Breast Neoplasms/drug therapy , Breast Neoplasms/pathology , Breast Neoplasms/radiotherapy , Combined Modality Therapy , Female , Humans , Lymphoma, Non-Hodgkin/drug therapy , Lymphoma, Non-Hodgkin/pathology , Lymphoma, Non-Hodgkin/radiotherapy , PrognosisABSTRACT
We report a case of primary squamous cell carcinoma of the breast in a 58 years old woman. The diagnosis of this rare tumor is possible after excluding a skin primary lesion or an epidermoid cancer of a distant site. In reviewing the reported cases we didn't find any significant prognostic difference between this form and the breast adenocarcinoma with squamous metaplasia.
Subject(s)
Breast Neoplasms/diagnostic imaging , Carcinoma, Squamous Cell/diagnostic imaging , Breast Neoplasms/pathology , Breast Neoplasms/surgery , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/surgery , Female , Humans , Mammography , Mastectomy, Modified Radical , Metaplasia/pathology , Middle AgedSubject(s)
Homosexuality, Female , Publications , Sexology , Sexuality , Wit and Humor as Topic , Women's Health , England/ethnology , Female , France/ethnology , Freudian Theory/history , History, 20th Century , Homosexuality, Female/ethnology , Homosexuality, Female/history , Homosexuality, Female/psychology , Humans , Language , Publications/economics , Publications/history , Sexology/education , Sexology/history , Sexual Behavior/ethnology , Sexual Behavior/history , Sexual Behavior/physiology , Sexual Behavior/psychology , Sexual Partners/psychology , Sexuality/ethnology , Sexuality/history , Sexuality/physiology , Sexuality/psychology , United States/ethnology , Wit and Humor as Topic/history , Wit and Humor as Topic/psychology , Women's Health/economics , Women's Health/ethnology , Women's Health/history , Women's Health/legislation & jurisprudence , Women's Rights/economics , Women's Rights/education , Women's Rights/history , Women's Rights/legislation & jurisprudence , Women, Working/education , Women, Working/history , Women, Working/legislation & jurisprudence , Women, Working/psychologyABSTRACT
Urinary excretion of three enzymes of different subcellular location in kidney tissue, alanine aminopeptidase (AAP), gammaglutamyltransferase (GGT), N acetyl-beta-D glucosaminidase (NAG), was carried out in 79 healthy adults and 108 healthy children and in 69 adults with various therapies: antibiotics (32 cases), non steroidal anti-inflammatory drugs (NSAIDs) (22 cases), cisplatinum (12 cases) and cyclosporine (3 cases). A circadian rhythm has been shown in children. In patients treated with antibiotics, the importance and duration of the increased enzymes urinary excretion were variable but the excretion of AAP was always higher than that of GGT and NAG. Short term therapies by NSAIDs were without influence on enzymuria but long term therapies produced a moderate increase of NAG excretion. Enzymuria increased immediately after cisplatinum administration and decreased after each daily dose, except in patients with previously high creatininemia. Cyclosporine induced a slight increase in AAP and NAG excretion. Enzymuria, thus, increased early reflecting a toxic effect of the drug at the cellular level whereas creatininemia increase, marker of renal fonctionnal insufficiency, occurs only occasionally and lately.
