Frequency of tri- or multiradial configurations in fragile X identification.

Using the FUdR system for fragile X induction, we have observed no triradial or bisatellited configurations at fra (X) (q27.3) in over 5,000 fra(X) chromosomes examined from over 150 fra(X) individuals. Based on our observations, and those of Turner and Jacobs (1983) and Daniel et al (1984), we hypothesize that triradial configurations may not occur at Xq27 with FUdR induction. To test this hypothesis we cultured whole blood simultaneously in parallel folate-deficient and FUdR fra(X) induction systems, and systematically examined fra(X) chromosomes for triradials. Neither autosomes nor X chromosomes exhibited any apparent triradial figures in the FUdR system, while 1.4% of the fra(X) chromosomes in TC 199 exhibited a triradial. Also we observed one autosomal triradial at 4q35. We conclude that triradial configurations occur in low frequencies in the folate deficient system and seldom if ever in the FUdR system.

Congenital measles--1982.

Measles acquired in utero has a broad spectrum of illness, ranging from mild to rapidly fatal disease. We encountered two case of perinatal measles during the 1982 epidemic. In both cases the mother became febrile 4 to 5 days before admission, and a typical morbilliform rash appeared a few hours prior to delivery. Physical examination of both infants was within normal limits. They were each treated with human serum globulin (0.25 ml/kg body weight). In one of them, a maculopapular rash appeared on the neck after 5 days, which rapidly spread to all the body. No catarrhal or constitutional signs were noted. Hyperbilirubinemia occurred in both infants, requiring an exchange transfusion in one. Both were discharged in excellent condition. Viral cultures were negative in both infants, while serological studies revealed hemagglutination inhibition antibodies in rising titers.