1.
Open Forum Infect Dis
; 6(10): ofz374, 2019 Oct.
Article
in English
| MEDLINE
| ID: mdl-31660340
ABSTRACT
In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell death-L1+ macrophages could be the T-cells partnership in immune exhaustion and virus escape.