ABSTRACT
Cutaneous pseudolymphomas have been defined as benign lymphocytic infiltrates of the skin that simulate cutaneous lymphoma clinically or histologically. The authors report on a 2-year-old boy with a lesion of molluscum contagiosum in which the inflammatory infiltrate that surrounded a cystlike structure containing molluscum bodies consisted of atypical hyperchromatic mononuclear cells with abundant mitotic figures, some of them atypical. Immunohistochemical investigation demonstrated that the infiltrate was predominantly composed of T lymphocytes. A previous report documented pseudoleukemia cutis associated with molluscum contagiosum, and this report expands the spectrum of histopathologic pseudomalignancies that may be seen in lesions of molluscum contagiosum.
Subject(s)
Molluscum Contagiosum/complications , Pseudolymphoma/complications , Skin Diseases/complications , Child, Preschool , Humans , Male , Molluscum Contagiosum/pathology , Pseudolymphoma/pathology , Skin/pathology , Skin/ultrastructure , Skin Diseases/pathologyABSTRACT
Thirteen biopsies from 8 patients with amiodarone-induced skin pigmentation were studied. Light microscopy showed that skin pigmentation of these patients was produced by solar elastosis, increase of melanin and accumulation of the properly called amiodarone pigment in the upper dermis. The degree of solar elastosis and the amount of amiodarone pigment was related to total doses of amiodarone. This pigment was negative for fat stains and positive for Masson-Fontana stain, and had neither birrefringency nor autofluorescence. Ultrastructurally, the granules of amiodarone pigment appeared as membrane-bound granules with a fingerprint-like lamellated structure, which others have related to lipofuscin. We conclude, however, that this pigment may be a metabolite of amiodarone, morphologically and histochemically related to melanin.
Subject(s)
Amiodarone/adverse effects , Benzofurans/adverse effects , Pigmentation Disorders/chemically induced , Skin/pathology , Adult , Aged , Amiodarone/analysis , Cytoplasmic Granules/analysis , Female , Humans , Male , Middle Aged , Photosensitivity Disorders/chemically induced , Pigmentation Disorders/pathology , Skin/ultrastructure , Sunlight/adverse effectsSubject(s)
Dermatitis/immunology , Adult , Dermatitis/diagnosis , Dermatitis/pathology , Diagnosis, Differential , Female , Humans , Immunity, Cellular , Killer Cells, Natural/immunology , Lupus Erythematosus, Systemic/diagnosis , Lupus Erythematosus, Systemic/immunology , Rosette Formation , Skin/pathology , Syndrome , T-Lymphocytes/immunologyABSTRACT
An ultrastructural study of a juvenile xanthogranuloma is presented. Foamy histiocytes reveal several vacuoles of irregular profile containing a type of lipid which is not fixed by osmium tetraoxide. There are also myelin figures. Plasmatic membrane shows numerous digit-like foldings related to collagen fibers. Cytoplasm containing few organelles are restricted to a narrow band around the nucleus and delicate trasverse bandings among the vacuoles. Several intranuclear spheroidal corpuscles have been identified in the histiocytes. Genesis of these foamy histiocytes is discussed probably related to a metabolic derangement of an organelle but in no way related to phagocytosis of fragmented polymorphonuclear leukocytes or Lymphocytes.
