ABSTRACT
Chitosan is a bio-degradable, bio-compatible, non-toxic, and renewable biopolymer. The reactive amino group of chitosan has gained importance because using these amino groups can help achieve the different types of structural modification in chitosan. Chemical modification of chitosan via imine functionalization results in the formation of a chitosan Schiff base. The present review covers the green synthesis of chitosan Schiff bases using non-conventional green methods such as microwave irradiation, green solvent, ultrasound irradiation, and one-pot synthesis. These methods are energy-efficient and greener versions of the conventional condensation methods. Scientists have paid significant attention to the chitosan Schiff base because of its unique properties and versatility. These molecules display various biological applications, including antioxidant, antimicrobial, anticancer, antibacterial, and anti-fungal. In addition to biological applications, chitosan Schiff base also has other applications like corrosion inhibition, catalysis, metal ion adsorption, and as a sensor. Available literature particularly shows the different methods for the synthesis of chitosan Schiff bases and their different applications. This review gives detailed insight regarding sustainable approaches to the synthesis of chitosan derived Schiff bases and their applications in various emerging fields.
