Surgical treatment of segmental spinal dysgenesis: a report of 19 cases.

STUDY DESIGN: Retrospective review. OBJECTIVE: To describe clinical presentation, surgical management, long-term results, and complications in patients with segmental spinal dysgenesis (SSD). In addition, we sought to emphasize early surgery for this complex congenital abnormality. SSD is a rare congenital malformation characterized by focal stenosis, spinal subluxation, kyphosis, and absence of the nerve roots. Neurologic function ranges from normal to complete paraplegia. Progression of the deformity and neurologic deterioration is the rule. METHODS: An independent spinal surgeon reviewed the complete records of 19 patients with SSD, between 1998 and 2015 at a single institution. Mean follow-up was 10 years and 6 months (2-14 years). RESULTS: We evaluated 11 males and 8 females, with a mean age of 2 years and 9 months (5 months-15 years). The dysgenetic segment involved an average of 2.9 vertebrae (1-5); the upper thoracic region was most commonly involved in ten cases. Fifteen patients had severe spinal stenosis. 14 patients presented neurological deficits and 15 patients had associated organ and musculoskeletal anomalies.Twenty-seven surgeries were performed, a mean of 1.76 procedures (1-5) to obtain solid fusion. Neurologic function improved in four, deteriorated in three, and remained unchanged in 12 patients Seven complications were recorded. CONCLUSION: We strongly recommend decompression and fusion as soon as possible to preserve or prevent neurologic deterioration. Although challenging, it was possible to achieve a solid instrumented fusion in all cases; however, a high rate of patients may deteriorate or not recover neurological status after surgery. LEVEL OF EVIDENCE: Level IV evidence.

Long-term results of hemivertebra excision: How does the spine behave after the peak of puberty?

INTRODUCTION: Early hemivertebra (HV) excision and posterior spinal fusion (PSF) is advocated as the treatment of choice in congenital kyphoscoliosis. We assessed global spinal balance and spinal deformity status once the pubertal peak has taken place, in children with a history of HV excision and PSF at age younger than 5 years. METHODS: Twenty-seven children with congenital kyphoscoliosis without co-existing proximal/distal congenital spinal abnormalities who underwent HV excision and PSF of ≤ 5 levels at age younger than 5 years and who had reached the peak of puberty at the last follow-up visit were evaluated. RESULTS: Twenty-seven HV excision were performed. Mean age at surgery was 3 years and 2 months. A mean of 3.2 segments were fused. Imbalance of the trunk was observed in 80% of thoracic and 75% of thoracolumbar HV excision. No arthrodesis technique (4 cases) presented 100% of spine decompensation. All children younger than 2 years at the time of surgery developed spinal imbalance. Eighteen patients (67%) had global spine imbalance; 81% male population and 63% of the female population. Mean age at surgery was 3 years + 2 months. Mean age of the patients at the time of the study was 15 years + 5 months. Mean follow-up was 12 years + 3 months. CONCLUSION: Many of these patients developed spinal imbalance and scoliosis worsened at the final follow-up. Early age at surgery, preoperative scoliosis severity, HV location, no arthrodesis technique, and the adding-on phenomenon may be involved.

Antibiotic prophylaxis in high-risk pediatric spine surgery: Is cefazolin enough?

STUDY DESIGN: Retrospective study. OBJECTIVE: To describe pathogens found in SSI during pediatric-instrumented spine surgery, and to assess the relationship between pathogens and the etiology of the spinal deformity. Surgical site infection (SSI) after pediatric spine fusion is a well-known complication with incidence rates between 0.5 and 42%, associated with the patient underlying disorder. Pathogens involved in SSI seem to be related to patient characteristics, such as the etiology of the spinal deformity. GNB (gram-negative bacilli) are more frequent in neuropathic, muscular, and syndromic conditions. High-risk pediatric patients with a spine deformity undergoing instrumented surgery might benefit from receiving perioperative intravenous prophylaxis for GNB. METHODS: We conducted a retrospective study at our tertiary-care pediatric hospital from January 2010 to January 2017. We reviewed records of all episodes of SSI that occurred in the first 12 months postoperatively. All patients who underwent instrumented spine surgery were included in this study. RESULTS: We assessed 1410 pediatric-instrumented spine surgeries; we identified 68 patients with deep SSIs, overall rate of 4.8%. Mean age at instrumented spine surgery was 12 years and 9 months. Time elapsed between instrumented surgery and debridement surgery was 28.8 days. Cultures were positive in 48 and negative in 20. Of the 48 positive culture results, 41 (72%) were GNB, 12 (21%) gram-positive cocci (GPC), three (5%) gram-positive anaerobic cocci (GPAC), and one (2%) coagulase-negative staphylococci (CoNS). Of the 68 patients with primary SSIs, 46 were considered to have a high risk of infection, which reported GNB in 81%, GPC in 15%, GPAC in 2%, and CoNS in 2%. CONCLUSION: Cefazolin prophylaxis covers GPC and CoNS, but GNB with unreliable effectiveness. Gram-negative pathogens are increasingly reported in SSIs in high-risk patients. Adding prophylaxis for GNB in high-risk patients should be taken into account when considering spine surgery. LEVEL OF EVIDENCE: IV.

Manejo del dolor posoperatorio por cirugía de columna en la población pediátrica: Resultados preliminares / Pain management following spinal surgeries in pediatric patients. Preliminary results

Introducción: Aproximadamente el 80% de los pacientes pediátricos sometidos a cirugía de columna refiere dolor moderado o severo en el posoperatorio inmediato. Objetivos: Describir la presencia de dolor y su intensidad durante el posoperatorio de una cirugía de columna en pacientes pediátricos y evaluar la eficacia del tratamiento analgésico actual. Materiales y Métodos: Se evaluaron pacientes sometidos a cirugía de columna, de entre 10 y 18 años, con capacidad mental para entender el propósito del estudio. Se utilizó el esquema de medicación estándar actual posoperatorio del hospital. Se constataron la presencia del dolor, la hora de comienzo, la localización y la intensidad (escala de valoración numérica), entre otras variables. Resultados: Se evaluó a 84 pacientes pediátricos, con una edad promedio de 12 años y 9 meses, al momento de la cirugía. Las etiología fueron: idiopática (41 casos), neuropática (14 casos), sindrómica (10 casos), muscular (7 casos) y misceláneas (12 casos). El puntaje promedio en la escala de valoración numérica fue de 2,1 antes de la cirugía; de 7,3 el día 1 posoperatorio y de 3,3 el día 6 posoperatorio/alta. El tiempo promedio de internación fue de 6.3 días, el costo económico global de la internación fue de USD1090 por paciente. Conclusiones: Un importante porcentaje de pacientes pediátricos refiere dolor moderado o severo en el posoperatorio de una cirugía de columna, tan solo la mitad recibe un esquema de manejo de dolor estandarizado y adecuado. El objetivo ulterior de este estudio será protocolizar el manejo del dolor con un enfoque multimodal. Nivel de Evidencia: III

Introduction: Around 80% of pediatric patients who undergo spine surgery report moderate to severe pain in the immediate postoperative (POP) period, and only half of them are treated according to an adequate and standardized pain management scheme. Objectives: To describe the type and intensity of POP pain in children who underwent spinal surgery and evaluate the effectiveness of the current pain management protocol. Materials and Methods: We assessed children between 10 and 18 years of age who were able to understand the purpose of the study. We recorded presence of pain, time of POP pain onset, location, and referred intensity of the pain using a numeric rating scale (NRS), among other variables. Results: Overall, 84 pediatric patients were evaluated. Mean age at surgery: 12 years and 9 months. Etiology: idiopathic (41 patients), neuropathic (14 patients), syndromic (10 patients), muscular (7 patients), and miscellaneous (12 patients). Mean preoperative NRS was 2.1 and 7.3 on POP day 1, 6.6 on POP day 2, 6.2 on POP day 3, 5.1 on POP day 4, 3.7 on POP day 5, and 3.3 on POP day 6/at discharge. Mean hospital stay was 6.3 days. The mean cost of hospital stay was USD 1090 per patient. Conclusions: A high percentage of pediatric patients who underwent spinal surgery reported moderate to severe pain in the POP period, and just half of them received a standardized pain management protocol. A pain management protocol with a multimodal focus should be considered in a near future. Level of Evidence: III

Quality of life and patient satisfaction in bracing treatment of adolescent idiopathic scoliosis.

BACKGROUND: Bracing is used as a valid non-surgical treatment for adolescent idiopathic scoliosis (AIS) to avoid progression of the deformity and thereby surgery. The effect of bracing treatment on quality of life of patients with AIS has been a topic of interest in the international literature. The aim of this study was to evaluate the quality of life and patient satisfaction during bracing treatment for AIS of a pediatric hospital. MATERIAL AND METHOD: We assessed a total of 43 non-consecutive female patients (mean age at questionnaire, 13 years and 1 month and 10 years and 8 months to 14 years and 5 months; mean period of usage of brace, 1 year and 7 months), with adolescent idiopathic scoliosis (AIS), older than 10 years of age until skeletal maturity, with a Risser sign less than 3 and scoliosis between 20 and 45°, treated with thoracolumbosacral orthosis (TLSO) for a period longer than 6 months, and without other comorbidities or previous surgeries, were evaluated. The patients were administered a previously validated to Spanish questionnaire on quality of life (Brace Questionnaire (BrQ); Grivas TB et al.). BrQ is a validated tool and is considered a disease-specific instrument; its score ranges from 20 to 100 points, and higher BrQ scores are associated with better quality of life. RESULTS: The patients reported using the brace for a mean of 17.6 h daily and for a mean period of 1 year and 7 months at the time of the study. Overall, 72% of the study population reported to be in some way psychologically affected by the brace wearing, 56% felt their basic motor activities were affected, 54% felt socialization with their environment was affected, 46% considered their quality of life deteriorated due to pain, and 40% reported conflicts in the school environment. CONCLUSION: Patients with AIS treated with bracing reported a negative impact (53.5% overall) on quality of life and treatment satisfaction in terms of psychological, motor, social, and school environment aspects. An interdisciplinary approach would be important for the integrated psychosocial care of these patients.

Neurophysiological Monitoring in Radiofrequency Ablation of Spinal Osteoid Osteoma With a Progressive Time and Temperature Protocol in Children.

STUDY DESIGN: Retrospective. Level IV Evidence. OBJECTIVE: To assess the utility of intraoperative neurophysiological monitoring (IONM) to detect and eventually prevent impending neurovascular damage during computed tomography (CT)-guided radiofrequency ablation (RFA) of spinal osteoid osteoma (OO) in children. SUMMARY AND BACKGROUND DATA: To our knowledge, this is the first case series of spinal OO in pediatric patients treated at a single center employing IONM during RFA. METHODS: This is a retrospective study of seven consecutive patients (3 girls and 4 boys, mean age: 9 years 4 months) with imaging and clinical signs compatible with spinal OO who underwent CT-guided RFA, under general anesthesia, and IONM in a single center between 2011 and 2015. Before the RFA procedure, a CT-guided percutaneous biopsy of the nidus was performed in the same setting. RFA was divided into four cycles of increasing time and temperature and performed under IONM in every patient. RESULTS: Two patients had lesions located in the thoracic spine and five patients had lumbar involvement. The RFA technical and clinical success was 85.7%. Six patients presented with reversible neurophysiological changes either during biopsy needle positioning or RFA cycles. In the remaining case, as IONM changes did not improve after several minutes of neuroprotective hypertension, the procedure was interrupted. Neither neurologic nor vascular complications were observed after RFA treatment. In only one biopsy sample, OO was confirmed by histopathologic studies. CONCLUSION: CT-guided RFA is an accepted minimally invasive technique for the treatment of spinal OO in children. IONM may be a helpful tool that requires minimal additional time and provides feedback on the state of the spinal cord and nerves at risk during the procedure. We promote the use of IONM during these procedures to detect and possibly prevent impending neurologic damage. LEVEL OF EVIDENCE: Level IV.

Surgical Treatment With Pedicle Screws of Scoliosis Associated With Osteogenesis Imperfecta in Children.

STUDY DESIGN: Retrospective study. OBJECTIVE: To assess results of posterior instrumented fusion using pedicle screws in 12 children with osteogenesis imperfecta (OI) with spinal deformity at a single institution from 2001 to 2012. SUMMARY OF BACKGROUND DATA: This is the first case series of OI patients who underwent non-cement augmented screw-rod instrumented fusion published in the literature. METHODS: Of a total of 54 children with spinal deformity associated with OI, 12 (22.2%) were submitted to posterior spinal fusion with pedicle screws (80% density) because of severe spinal deformity. Here we reported the results in seven females and five males. RESULTS: Five thoracic (41.7%), five double (thoracic and lumbar 41.7%), and two lumbar (16.7%) curves were considered. The mean number of fused levels was 11.8 (range: 5 to 16). Mean age at surgery was 13 years 8 months. Mean follow-up was 7 years 11 months (range: 3 years 7 months to 16 years 1 month). The mean preoperative scoliosis angle was 75.6°, whereas the postoperative angle was 31.4° (58.5% correction rate). The mean preoperative kyphosis angle was 57.4° and the postoperative angle was 42.3°. We observed one superficial infection, one dural tear, and three cases of proximal junctional kyphosis; two patients required one revision surgery each (2 years and 4 months postoperatively on average). CONCLUSIONS: To our knowledge, this is the first case series published in the literature regarding OI with instrumented fusion with non-cement augmented pedicle screws exclusively in children with spinal deformity. We found that posterior spinal fusion with the screw-rod system in OI deformity in children is feasible and reliable, and has acceptable clinical and imaging results in the long-term follow-up. LEVEL OF EVIDENCE: Level IV.

Evolución de las complicaciones neurológicas en la cirugía de deformidades vertebrales en la infancia

Introducción: Se llevó a cabo un estudio retrospectivo descriptivo con el propósito de evaluar cómo evolucionaron los pacientes que sufrieron trastornos neurológicos a causa de una cirugía de las cifoescoliosis en la infancia. Materiales y Métodos: Se evaluó a 9 pacientes sin alteraciones neurológicas previas, que presentaron complicaciones neurológicas luego de un procedimiento quirúrgico por escoliosis o cifosis, operados en nuestra institución, durante un período de 10 años. Resultados: Las etiologías de las deformidades fueron: 4 escoliosis idiopáticas, 2 escoliosis congénitas, una secundaria a neurofibromatosis de tipo 1, una cifosis idiopática y una poslaminectomía por miofibrosarcomatosis. Cinco pacientes tuvieron episodios neurofisiológicos intraquirúrgicos. Todos requirieron, al menos, una segunda intervención quirúrgica para solucionar su patología de base. La lesión neurológica fue: lesión radicular (un caso) y lesión del cordón medular (8 casos); 6 sufrieron una lesión medular completa (75%) que se manifestó como una paresia bilateral y 2 (25%), una lesión medular incompleta con monoparesia, sólo 2 quedaron con vejiga neurogénica. Conclusión: La detección temprana de una complicación neurológica, su diagnóstico etiológico y la resolución quirúrgica mejoran la evolución neurológica del paciente, y evitan la secuela o disminuyen su gravedad.(AU)

Background: A retrospective descriptive study was performed to assess the outcome of neurological complications due to kyphosis or scoliosis surgery in children. Methods: Nine patients who suffered neurological complication during kyphosis and/or scoliosis deformity surgery operated on our institution from May 2003 to June 2013 were evaluated. Results: Etiologies observed were: 4 idiopathic scolioses, 2 congenital scolioses, one associated with neurofibromatosis type 1, one idiopathic kyphosis and one myofibrosarcomatosis post-laminectomy surgery. Five patients presented intraoperative neurological changes. All patients needed at least a second surgical intervention to solve the spine deformity. The topographic classification of the neurological injury was: radicular injury (one patient); spinal cord injury (8 patients), 6 presented complete spinal injury (75%) which manifested with bilateral paresis and 2 patients (25%) suffered an incomplete spinal injury with monoparesis, only 2 stayed with neurogenic bladder. Conclusion: Early detection of a neurological complication, its etiological diagnosis and surgical resolution improve neurological outcome, avoiding or reducing its sequel.(AU)

Hemivertebra Resection With Instrumented Fusion by Posterior Approach in Children.

STUDY DESIGN: We conducted a retrospective study of patients with congenital scoliosis due to hemivertebra (HV) and performed resection with instrumentation through posterior approach-only with long term follow-up. OBJECTIVES: The objective of this study was to assess results of HV resection by posterior approach-only with instrumentation between 2002 and 2011. SUMMARY AND BACKGROUND DATA: Hemiepiphysiodesis, arthrodesis in situ and resection without instrumentation had been performed in the past with different results. Hemivertebra resection with spinal instrumentation through anterior and posterior approach has been advocated as the treatment of choice. METHODS: A total of 67 patients with 78 HV and 70 surgical procedures were evaluated. Thirty-five of the patients were females and 32 were males. The mean age of the patients was 5.5 years (from 0.8 to 16 yr), and the mean follow-up period was 6.55 years (from 2.1 to 10.8 yr). Eighteen patients presented additional pathologies: specific syndromes, cardiopathies, thoracic, abdominal, and bone malformations. Sixteen patients had partial HV while 51 had full mobility HV. Twenty-eight of the HV were thoracic, 16 thoracolumbar, 28 lumbar, and six lumbosacral. RESULTS: The scoliosis mean preoperative angular value was 38.55°, and the mean postoperative angular value was 19.89°. The kyphosis mean preoperative angular value was 29.98° and the mean postoperative angular value was 15.41°. One rod was used in 38 surgical procedures (54.28%) and 2 rods in 32 procedures (45.72%). We used monoaxial screws in 45 patients, poliaxial screws in 17 patients, and both monoaxial screws and poliaxial screws in one patient. Screws and hooks were used in one patient and hooks in three patients. Arthrodesis was performed in 64 patients, and no complications were registered in those without arthrodesis. Postoperative orthesis was used in 57 opportunities. Several complications during or after HV resection by posterior approach-only were reported. Two patients suffered from intraoperative neurophysiological complications, which were resolved during surgery with minimum gestures and presented no sequelae. Two patients developed superficial infections and needed toilette and IV antibiotic therapy. Two patients needed an additional surgery due to secondary curves, 4.9 yr after primary surgery on average. One patient developed crankshaft. CONCLUSIONS: We concluded that HV resection by posterior approach-only with instrumentation is a simple, secure, reliable, less invasive and well tolerated technique that can successfully resolve this kind of congenital scoliosis in children.

Estudio comparativo entre la toracoscopía videoasistida y la toracotomía convencional, para la artrodesis vertebral anterior en el tratamiento de la escoliosis en niños y adolescentes / Comparative study between videoassisted thoracoscopy and conventional thoracotomy, for anterior vertebral arthrodesis in the treatment of the scoliosis in child and adolescents

Introducción: la escoliosis es la deformidad que más frecuentemente requiere tratamiento en niños y adolescentes. El tratamiento con corsets mantiene vigencia en curvas de más de 20º con pacientes esqueléticamente inmaduros. Para curvas torácicas superiores a 40-45º y de acuerdo al patrón de distribución de la misma se considera la indicación quirúrgica. El estado actual del tratamiento quirúrgico contempla la corrección, estabilización y artrodesis con implante por vía posterior o anterior en forma aislada y la realización de procedimientos combinados de artrodesis anterior simple seguida de corrección, estabilización y artrodesis por vía posterior. Para esta alternativa combinada se ha introducido en la última década la posibilidad de realizar el tiempo vertebral anterior por abordaje mínimamente invasivo toracoscópico manteniendo la estabilización convencional y colocación de implante por vía posterior y muy recientemente se comenzo a aplicar todo el proceso de artrodesis, corrección y estabilización por vía anterior con abordaje toracoscópico videoasistido. Objetivo: el objetivo de este trabajo es demostrar que el abordaje toracoscopico videoasistido para realizar artrodesis vertebrales a nivel torácico, en deformidades vertebrales de niños y adolescentes, tiene comparativamente con la técnica de abordaje convencional por toracotomía similares indicaciones y resultados finales con menor tasa de complicaciones postoperatorias... (TRUNCADO)

Estudio comparativo entre la toracoscopía videoasistida y la toracotomía convencional, para la artrodesis vertebral anterior en el tratamiento de la escoliosis en niños y adolescentes / Comparative study between videoassisted thoracoscopy and conventional thoracotomy, for anterior vertebral arthrodesis in the treatment of the scoliosis in child and adolescents

Introducción: la escoliosis es la deformidad que más frecuentemente requiere tratamiento en niños y adolescentes. El tratamiento con corsets mantiene vigencia en curvas de más de 20º con pacientes esqueléticamente inmaduros. Para curvas torácicas superiores a 40-45º y de acuerdo al patrón de distribución de la misma se considera la indicación quirúrgica. El estado actual del tratamiento quirúrgico contempla la corrección, estabilización y artrodesis con implante por vía posterior o anterior en forma aislada y la realización de procedimientos combinados de artrodesis anterior simple seguida de corrección, estabilización y artrodesis por vía posterior. Para esta alternativa combinada se ha introducido en la última década la posibilidad de realizar el tiempo vertebral anterior por abordaje mínimamente invasivo toracoscópico manteniendo la estabilización convencional y colocación de implante por vía posterior y muy recientemente se comenzo a aplicar todo el proceso de artrodesis, corrección y estabilización por vía anterior con abordaje toracoscópico videoasistido. Objetivo: el objetivo de este trabajo es demostrar que el abordaje toracoscopico videoasistido para realizar artrodesis vertebrales a nivel torácico, en deformidades vertebrales de niños y adolescentes, tiene comparativamente con la técnica de abordaje convencional por toracotomía similares indicaciones y resultados finales con menor tasa de complicaciones postoperatorias... (TRUNCADO)(AU)

Artrodesis anterior: toracoscopía en escoliosis

En el segundo semestre de 1996 realizamos los primeros 4 procedimientos toracoscópicos en columna torácica anterior en la Unidad de Patología Espinal del Hospital Dr. Juan P. Garrahan, incorporando técnicas de incipiente aplicación en otros lugares del mundo. Se realizaron en 4 pacientes un total de 20 niveles de remoción discal y artrodesis anterior a nivel torácico. Tres fueron escoliosis idiopáticas y una escoliosis neuropática asociada con siringomielia. El objetivo fue, en 3 casos, aumentar el área transversal de artrodesis y la flexibilidad de la curva, y en un caso evitar el fenómeno "cigüeñal", debido a la inmadurez esquelética. Los procedimientos fueron siempre complementados por un tiempo posterior instrumentado en fecha distinta. Los valores angulares de escoliosis oscilaron entre 45 y 115 grados. El objetivo quirúrgico fue alcanzado en los 4 casos sin necesidad de conversión a toracotomía abierta. Demandó más tiempo quirúrgico y mayores requerimientos técnicos y anestésicos que una toracotomía convencional. Tuvimos un neumotórax como única complicación postoperatoria. La evolución postoperatoria inmediata, la rápida recuperación funcional, la buena cosmesis de la herida y el excelente resultado final motivan nuestro actual uso de la técnica como rutina, con frecuencia creciente y en variadas etiologías que requieran procedimientos vertebrales anteriores a nivel torácico

Artrodesis anterior: toracoscopía en escoliosis

En el segundo semestre de 1996 realizamos los primeros 4 procedimientos toracoscópicos en columna torácica anterior en la Unidad de Patología Espinal del Hospital Dr. Juan P. Garrahan, incorporando técnicas de incipiente aplicación en otros lugares del mundo. Se realizaron en 4 pacientes un total de 20 niveles de remoción discal y artrodesis anterior a nivel torácico. Tres fueron escoliosis idiopáticas y una escoliosis neuropática asociada con siringomielia. El objetivo fue, en 3 casos, aumentar el área transversal de artrodesis y la flexibilidad de la curva, y en un caso evitar el fenómeno "cig³eñal", debido a la inmadurez esquelética. Los procedimientos fueron siempre complementados por un tiempo posterior instrumentado en fecha distinta. Los valores angulares de escoliosis oscilaron entre 45 y 115 grados. El objetivo quirúrgico fue alcanzado en los 4 casos sin necesidad de conversión a toracotomía abierta. Demandó más tiempo quirúrgico y mayores requerimientos técnicos y anestésicos que una toracotomía convencional. Tuvimos un neumotórax como única complicación postoperatoria. La evolución postoperatoria inmediata, la rápida recuperación funcional, la buena cosmesis de la herida y el excelente resultado final motivan nuestro actual uso de la técnica como rutina, con frecuencia creciente y en variadas etiologías que requieran procedimientos vertebrales anteriores a nivel torácico