[Effect of lycopene on blood lipoproteids in women with type 2 diabetes mellitus in postmenopause]. / Deistvie likopina na lipoproteidy krovi u zhenshchin s sakharnym diabetom 2 tipa v postmenopauze.

Blind randomized placebo-control research included 39 women. The following criteria were: menopause period for more then 1 year long; diabetes mellitus; arterial hypertension; hypercholesterolemia. The patients were divided into two groups. Women from the first group (N = 24) were given 30 mg lycopene (composed with "Tomatol") per day during 24 weeks. The second group (N = 15) were given placebo. It was showed that during 12-week "Tomatol" intake we state that lycopene concentration in serum increased twice (337.0 +/- 133.0 nM), total cholesterol (CH) and CH LDL decreased by 12% and 16% respectively. The lipoproteins spectrum normalization correlated to serum antioxidative activity (r = 0.30, p < 0.05), and malonic dialdehyde concentration decrease by 44.8% correlated to lycopene increase (r = -0.51, p < 0.05). Our results give us a possibility to use "Tomatol" as an additional medicine for the prevention of atherosclerosis.

[Indicators of central hemodynamics in patients with disorders of cardiac rhythm and conductivity and nonspecific ECG changes without organic myocardial lesions]. / Pokazateli tsentral'noi gemodinamiki u bol'nykh s narusheniiami ritma i provodimosti serdtsa, nespetsificneskimi izmeneniiami EKG bez organicneskogo porazheniia miokarda.

Pulmonary arterial diastolic pressure (PADP) and cardiac index (CI) were measured by thermodilution at rest and during sitting bicycle ergometry in 95 patients at risk for cardiomyopathy in the future. Normal parameters were recorded in 85 patients: CI increased at least 2.5-fold, and PADP was within 16 mmHg at the peak of exercise. Ten patients showed an abnormal rise of PADP up to 29.0 +/- +/- 1.2 mmHg in the presence of an adequate CI increment. This may be an early manifestation of myocardial contractility disorders.

[Hemodynamic effect of foridon and nifedipine at rest and during exercise]. / Gemodinamicheskoe deistvie foridona i nifedipina v pokoe i pri nagruzke.

In an acute experiment, hemodynamic effects of ryodipine, 30 mg, were compared with those of nifedipine, 30 mg, in 22 patients with circulatory failure at rest (n = 22) and during bicycle ergometer exercise testing (n = 10). During exercise, the two drugs significantly increased the maximal cardiac index values. Ryodipine induced no increment in elevated pulmonary diastolic pressure, whereas nifedipine significantly diminished the increase. Total pulmonary resistance increased during the initial load exercise, remained unaltered with ryodipine, while nifedipine decreased this parameter in response to the load exercise. Thus, hemodynamic effects of ryodipine and nifedipine were similar at rest, the latter drug being more efficient during exercise. The effects of the drugs in question were similar to those of peripheral arteriolar vasodilators such as hydralazine.

[Cardiac index and pressure in the pulmonary artery during physical loading of patients suspected of latent heart failure]. / Serdechnyi indeks i davlenie v legochnoi arterii vo vremia fizicheskoi nagruzki pri podozrenii na skrytuiu serdechnuku nedostatochnost'.

Pulmonary arterial diastolic blood pressure (PADBP) and cardiac index (CI) were measured by thermodilution at rest and during exercise (sitting bicycle ergometry) in 24 patients. CI grew at least 2.5-fold, and PADBP was never beyond 16 mm Hg at the peak of exercise in individuals showing no signs of coronary and myocardial disorders. Similar findings were demonstrated in 6 of 9 patients with idiopathic heart rhythms disorders. In 3 patients, exercise provoked a PADBP rise above 30 mm Hg, possibly an evidence of early myocardial contractility disturbance. Six coronary patients showed these patterns of response: no abnormal changes, or a PADBP rise in the presence of normal CI, or a PADBP rise combined with declining CI. These findings are attributed to developing heart failure, an impairment of myocardial relaxation or the absence of myocardial dysfunction.

[Diastolic pressure in the pulmonary artery and cardiac output in patients with ischemic heart disease during physical load]. / Diastolicheskoe davlenie v legochnoi arterii i serdechnyi vybros u bol'nykh ishemicheskoi bolezn'iu serdtsa vo vremia fizicheskoi nagruzki.

In 20 patients with IHD without clinical symptoms of heart failure, diastolic pulmonary artery blood pressure (DPAP) and cardiac index (CI) were studied at rest and during physical load (bicycle exercise in sitting position). The control group consisted of 15 patients without any symptoms of coronary artery or myocardium damage. The patients with IHD exhibited several types of heart reaction to exercise. In 6 of 20 patients reaction of DPAP and CI corresponded to that in normal subjects: at maximal load DPAP did not exceed 16 mm Hg, and CI increased by more than 250%. The contractile function of the left ventricular myocardium in these patients was not disturbed when there was no angina attack. 7 patients with IHD exhibited disturbance of diastolic myocardium relaxation, and 7 more patients had myocardial disfunction of various degrees. Treatment was carried out according to the determined changes in DPAP and CI during exercise.