1.
Bioorg Khim
; 11(1): 21-30, 1985 Jan.
Article
in Russian
| MEDLINE
| ID: mdl-2985089
ABSTRACT
The synthesis of 5 analogues of the effective inhibitor of peptidyl dipeptidase, teprotide, has been carried out. The inhibitory and bradykinin-potentiating activity of these compounds has been assayed. N-Terminal pyroglutamic acid and positive charge of arginine in position 4 were found to be essential for biological activity of the inhibitor.