ABSTRACT
Experimental studies of the mussels hydrolysate (MIGI-K) have shown that this preparation can enhance the radioresistance and general resistance of the organism. The mechanisms of its action are related mainly with its influence on the components of the biochemical back-ground of the resistance and with its antioxidative activity. Some properties of this preparation, for example, absence of toxicity and harmful side effects, made it possible as an adaptogene and as a remedy, increasing radionuclides excretion.
Subject(s)
Food Additives/therapeutic use , Power Plants , Protein Hydrolysates/therapeutic use , Radiation Injuries/rehabilitation , Radiation-Protective Agents/therapeutic use , Radioactive Hazard Release , Animals , Bivalvia , Humans , Lipid Peroxidation/drug effects , Lipid Peroxidation/radiation effects , Megakaryocytes/drug effects , Megakaryocytes/radiation effects , Mice , Radiation Injuries/blood , UkraineABSTRACT
Acid mussel hydrolisate MIGI-K LP is a food product, and a medical and prophylactic preparation containing a full set of irreplaceable amino acids (with the exception of thriptophane), essential fatty acids, macro- and microelements. MIGI-K LP can be used as a foot additive which improves the taste and increases the food qualities of the product, and as a medical preparation against some diseases.
Subject(s)
Bivalvia/metabolism , Food Additives/isolation & purification , Free Radical Scavengers/isolation & purification , Protein Hydrolysates/isolation & purification , Radiation-Protective Agents/isolation & purification , Shellfish , Adolescent , Adult , Aged , Amino Acids/analysis , Animals , Child , Child, Preschool , Fatty Acids/analysis , Gastrointestinal Diseases/diet therapy , Hepatitis B/diet therapy , Hepatitis C/diet therapy , Humans , Infant , Middle Aged , Quality Control , Trace Elements/analysisABSTRACT
Antiviral properties were found with a preparation obtained from mussel meat by acid hydrolysis. In the experiments in vitro this mussel hydrolysate reduced the infectious activity of influenza viruses in neutralization tests by 3-6 log. Applications of the preparation to mice infected with a toxigenic influenza virus strain protected from death 66-84% of the animals, the survival rate in controls being from 9 to 16%. The protective effect of mussel hydrolysate was observed both after intranasal and oral administrations. The optimal protective effect was obtained when the preparation was used 5-24 hours before inoculation.
Subject(s)
Antiviral Agents/pharmacology , Bivalvia , Meat , Protein Hydrolysates/pharmacology , Animals , Antiviral Agents/isolation & purification , Antiviral Agents/therapeutic use , Cells, Cultured , Chick Embryo , Depression, Chemical , Drug Evaluation, Preclinical , Influenza A virus/drug effects , Influenza B virus/drug effects , Mice , Orthomyxoviridae Infections/drug therapy , Orthomyxoviridae Infections/mortality , Protein Hydrolysates/isolation & purification , Protein Hydrolysates/therapeutic useABSTRACT
Noninbred female white rats were fed for 30 days with diets containing 137Cs and 85Sr in indicative doses. After that the animals received some sea products to investigate their radioprotective properties. Natural sea products proved able to influence the kinetics of the radionuclides metabolism. Laminaria salad "Dalnevostochny" given in the dose 20 g per animal reduced the accumulation of radioactive Cs and Sr by 76.7 and 57.6%, respectively. Moreover, sea products stabilize functional activity of peripheral blood natural killers which are important in immunological defense of the body.
Subject(s)
Cesium Radioisotopes , Fish Products , Food Contamination, Radioactive , Strontium Radioisotopes , Accidents , Animals , Cesium Radioisotopes/administration & dosage , Cesium Radioisotopes/metabolism , Female , Nuclear Reactors , Rats , Strontium Radioisotopes/administration & dosage , Strontium Radioisotopes/metabolism , UkraineABSTRACT
The physico-chemical properties of preparation MIGI-K from mussels are given. Some characteristics of melanoidin fractions of MIGI-K are presented, their similarity to standard melanoidin is revealed. The given data on biological activity of the preparation permit to consider MIGI-K as immunomodulator.
