[Assessment of the incidence of metabolic syndrome]. / Posouzení frekvence výskytu metabolického syndromu.

BACKGROUND: Metabolic syndrome represents a disease with high prevalence and influence on the cardiovascular morbidity and mortality. The aim of this study is to estimate frequency of metabolic syndrome in the district Sumperk, in years 1979-1981 based on the analysis of large Preventive check-ups database. METHODS AND RESULTS: Database of Preventive oncologic check-ups from Sumperk district comprising 40 099 subjects with follow up in years 1979-1981 has been used to assess the metabolic syndrome prevalence. Incidence of the risk factors of the metabolic syndrome have been calculated and compared with current situation in the Czech Republic. The estimated incidence of metabolic syndrome ranged from 2.2% to 8.4%, according to the selected criteria. As risk factors diabetes type II or glycaemia higher than 6.1 mmol/l, systolic or diastolic hypertension and BMI higher than 30.0 kg/m2 were considered. It has been found that metabolic syndrome is increasing with increasing age in both male and female population. CONCLUSIONS: It is possible to assume, based on the results of this study that the incidence of the metabolic syndrome is increasing in the last decades. It is necessary to focus our attention on the simple and practical methods for early detection of metabolic syndrome. Important is also the prevention because metabolic syndrome plays important role as a predictor of serious cardiovascular and metabolic diseases.

Lung cancer incidence in the Czech Republic: a time-trend study.

BACKGROUND: Analysis of cancer incidence trends is one of the prerequisites for cancer prevention. It is possible to set up priorities and assess current development of morbidity. METHODS: All lung cancer incidences in the Moravia region of the Czech Republic (4,000,000 inhabitants) in the years 1984-1998 have been assessed concerning incidence, anatomical subsites, stage, and morphology. Age and sex distribution have been taken into consideration. RESULTS: There has been a continuous increase in the incidence of lung cancer in females and a mild decrease in males. In both sexes the most affected anatomical subsites were upper and lower lobe of the lung. Stage III and IV predominated. Main morphological type was squamous cell carcinoma in males (39.3%) and in females (22.2%), the second most frequent type in males was small cell carcinoma (13.6%) and in females adenocarcinoma (21.8%). The highest incidence was observed in the age group of 55-75 in males and 60-80 in females. CONCLUSION: Lung cancer epidemiology and prevention is one of the top-priority health problems in the Czech Republic. The incidence is one of the highest in the world especially for males; in females it is continuously increasing. Primary prevention is available but difficult to implement, particularly non-smoking. Secondary prevention is not available due to lack of suitable screening tests and a short lead time.

[Risk factors for tumors, cardiovascular and metabolic diseases in the population of the Sumperk District]. / Rizikové faktory nádorových, kardiovaskulárních a metabolických nemocí u populace okresu Sumperk.

BACKGROUND: Cardiovascular diseases and cancers are responsible for almost 80% of the total mortality in the Czech Republic. For their prevention, identification of risk factors becomes indispensable. Presented article analyses frequency of risk factors in the population of Sumperk district on the bases of the first and second preventive oncological check-ups. METHODS AND RESULTS: Diagnoses have been unified according to the International Classification of Diseases. For data analysis SPSS statistical software has been used. Frequency of obesity, hypertension, hyperglycemia, hypercholesterolemia, hyperuricemia and smoking has been assessed in subjects during their first and second preventive check-ups. In the course of the first check-up 49,426 subjects have been examined, out of them 22,857 males (46.2%) and 26,569 females (53.8%). 40,386 subjects participated in the second check-up (18,378 males and 22,008 females). The assessment of the frequency of the individual risk factors has been done on the bases of the examination results. CONCLUSIONS: Total incidence of obesity was lower in males comparing to the data from the population of 6 districts of the Czech republic (MONICA). Due to the treatment of subjects, there was a mild decrease of prevalence of the systolic hypertension in the second check-up in comparison with the first one. In comparison with MONICA project, the incidence of hypertension was more than twice higher. No difference in frequency of hyperglycemia in males and females was found. In both genders, high prevalence of hypercholesterolemia (about 70%) was found. Between two check-ups, decrease of hypercholesterolemia prevalence was observed. It corresponds with the existing trend in the Czech population. Decrease of smoking prevalence has been observed in the second check-up mainly in males and less in females. In comparison with MONICA project, there was a higher smoking prevalence in males and a lower one in females.

Prognostic factors in Hodgkin's disease.

Between 1978-84 371 patients with HD were treated according to Protocol of LCG. 72.5% achieved complete, 10.8% partial remission and 16.7% were nonresponders. The evaluation of results was performed by PIL program from BMDP 81. The mean survival was 61 and disease-free survival (DFS) 60 months. The cumulative survival and DFS at 5 years were 65% and 68%, resp. Advanced HD, B symptoms, histopathology LD, male sex and age above 40 years influenced survival adversely. DFS decreased with CS III B, in males and age above 60 years significantly and in histopathology MC and LD with lack of significance. However, the size of mediastinal involvement was not a poor prognostic factor for survival, but influenced DFS. The prognostic value of major risk factors in HD was estimated by means of frequencies of their associations.

Antiimmunoglobulins of rheumatoid factor (RF) type in prediction of melanoma patients.

It was found out the titer of antiimmunoglobulins of the rheumatoid factor (RF) type in the sera of melanoma patients can be used in prediction of the development of the patients' status. High titers of antiimmunoglobulins of the RF type, determined by the latex-fixation test (LFT), indicate an unfavorable prognosis in patients with clinical manifestation of uncontrollable recurrence appearing from 1.5 to 2 years after occurrence of the LFT titer.