ABSTRACT
A clinical-experimental study was carried out. The objective was to find some regularities in endothelial disorder progression in patients with severe sepsis and to evaluate clinical efficacy of some methods of hepatic protection. Experimental part of work was carried out on 59 mice with induced peritonitis. Obtained data shows early emergence of lung disorders that precede changes in hepatic tissue. Clinical part of work included 181 patient with severe sepsis. It was noted that acute respiratory distress syndrome symptoms occurred earlier than hepatic dysfunction, if the latter joints, it aggravates the patients status and worsens the prognosis. Use of Heptral (Ademetionine) and Ketamine in order to protect liver is a clinically effective method which makes possible to decrease the lethality.
Subject(s)
Endothelium, Vascular/pathology , Hepatic Insufficiency/prevention & control , Liver , Lung , Respiratory Distress Syndrome/prevention & control , Sepsis/pathology , APACHE , Adolescent , Adult , Aged , Aged, 80 and over , Animals , Biomarkers/analysis , Endothelium, Vascular/drug effects , Female , Hepatic Insufficiency/complications , Hepatic Insufficiency/mortality , Hepatic Insufficiency/pathology , Humans , Ischemia/complications , Ischemia/mortality , Ischemia/pathology , Ischemia/prevention & control , Ketamine/administration & dosage , Ketamine/therapeutic use , Liver/blood supply , Liver/drug effects , Liver/pathology , Lung/blood supply , Lung/drug effects , Lung/pathology , Male , Mice , Middle Aged , Rats , Respiratory Distress Syndrome/complications , Respiratory Distress Syndrome/mortality , Respiratory Distress Syndrome/pathology , S-Adenosylmethionine/administration & dosage , S-Adenosylmethionine/therapeutic use , Sepsis/complications , Sepsis/drug therapy , Sepsis/mortality , Young AdultABSTRACT
A prospective longitudinal controlled investigation of 189 patients with secondary diffuse peritonitis was performed. A correlation between the levelof interleuikin-6 of peritoneal exudate, the severity of the patients' state, the number of complications and outcome of the course of the disease was established. The maximal number of complications and unfavorable outcomes falls on the peak value ofinterleuikin-6.
