ABSTRACT
Structural metabolic changes in the biopsies of the large bronchi mucous membrane were studied in 99 patients with chronic lung diseases. Progressing sclerosis of the connective tissue stroma resulted in the reduction of endotheliocyte metabolism which usually represent plastically active zone of the strom. This considerably influences basal cell proliferation resulting in changes of differentiation in bronchial epithelium. Endobronchial laser therapy induces proliferative and metabolic processes in the tunica propria of the mucous membrane. Congestion, intensive leucodia pedesis, leucocytic infiltrates and granulations develop in the mucous membrane, proliferative and metabolic activity of endotheliocytes and stromal cells increases this resulting in formation of fine fibrillar connective tissue.
Subject(s)
Bronchi/blood supply , Bronchitis/pathology , Laser Therapy , Bronchi/ultrastructure , Capillaries/pathology , Cell Differentiation/physiology , Chronic Disease , Mucous Membrane/pathologyABSTRACT
Structural and metabolic changes were studied in 162 large bronchial mucosa biopsy specimens from 63 patients with chronic lung diseases. Proliferative and metabolic processes were shown to be induced by endotracheal therapy with helium-neon laser for the damaged epithelium, which passed through a number of transitional forms and repaired its structure and differentiation into ciliary and goblet cells with normal ultrastructure. In lamina propria, there was hyperemia, intensive leukodiapedesis, formation of leukocytic infiltrated and granulations, the metabolic activity of endotheliocytes and interstitial cells increased, giving rise to delicate fibrous connective tissue. The simultaneous reorganization of the epithelium and underlying connective tissue is interpreted from the standpoint of a concept of parenchymal and stromal relationships.
