ABSTRACT
THE AIM OF THE STUDY: Comparative evaluation of determining the hygienic state of the mouth in patients using classical methods (index evaluation) and using the digital platform. MATERIAL AND METHODS: The study included 25 patients aged 16 to 60 years (women - 18, men - 7). A parallel determination of the level of oral hygiene using classical and digital approaches was carried out, the results obtained were compared and analyzed. RESULTS: When comparing the results obtained using both methods, it was revealed that in 24 out of 25 cases they turned out to be identical. The use of a digital protocol requires about two times less time than using the classical approach and allows for dynamic monitoring of the oral hygiene. CONCLUSION: The conducted research has shown that assessed digital platform is not inferior to the standard method of determining the level of hygiene. The result obtained using the digital platform gives a real-time visual representation of the level of oral hygiene of the patient, as it contains a transcript of the data and a detailed description of the type of dental deposits (the intensity of staining reflects the time interval of plaque formation).
Subject(s)
Mouth , Oral Hygiene , Male , Humans , Female , Oral Hygiene Index , Dental Plaque IndexABSTRACT
Urinary steroid profiling (USP) was studied using high-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS) methods in 108 patients with adrenocortical adenoma (ACA) and in 31 patients with adrenocortical carcinoma (ACC). Thirteen ACC and Cushing's syndrome (ACC-CS) patients had two types of USP as well as 18 ACC patients without hypercortisolism. These four types differed by androgen and glucocorticoid secretion of the adrenal cortex. Fifteen main ACC features were observed by GC-MS. Urinary excretion of dehydroepiandrosterone (DHEA) was increased in 67.7 % of ACC patients and tetrahydro-11-deoxycortisol (THS) in 74.2 %. By combination of the following parameters: THS >900 µg/24 h and/or DHEA >1500 µg/24 h with ratios of 3α,16,20-pregnentriol/3ß,16,20-pregnentriol (3α,16,20dP3/3ß,16,20dP3) less than 6.0 and 3α,17,20dP3/3ß,17,20dP3 less than 9.0 and the detection of "non-classical" 5-en-pregnens, not found in ACA and healthy persons, 100 % sensitivity and specificity of ACC and ACA differential diagnosis were achieved. Features of 21-hydroxylase and 11ß-hydroxylase deficiency were observed by GC-MS in 32.2 and 61.3 % of the ACC patients, respectively. Additional features for ACC-CS diagnostic were increased urinary excretion of 6ß-hydroxycortisol, 18-hydroxycorticosterone, the sum (UFF + UFE) obtained by HPLC, tetrahydrocorticosterone, and the sum (THF + THE + allo-THF) obtained by GC-MS.
