ABSTRACT
Introducción: El efecto de la donación a repetición de plaquetas por aféresis sobre el eritrograma se desconoce para población colombiana. Objetivo: Evaluar los cambios en la línea eritroide de donantes habituales de plaquetoaféresis de dos bancos de sangre de Medellín. Métodos: Estudio longitudinal con 100 donantes repetitivos de plaquetoaféresis con 3 donaciones o más. La fuente de información fueron las bases de datos de los bancos de sangre participantes. Los datos demográficos, tiempo entre donaciones y parámetros eritocitarios fueron consignados en una base de datos de excel y analizados empleando el software SPSS versión 27.0. Se realizó descripción de variables mediante medidas de resumen y se emplearon las siguientes pruebas estadísticas: T de Student, U de Mann Whitney, correlaciones, T pareada y Wilcoxon, considerándose un nivel de significación estadística de <0,05. Resultados: El 58% de los donantes fueron mujeres, el 75% tenían 30 años o más y 70% residían en el área metropolitana. No se observaron diferencias estadísticamente significativas para la hemoglobina según sexo y grupo etario, el VCM aumentó en la segunda, tercera y cuarta donación respecto a la primera, el HCM disminuyó en la cuarta donación respecto a la primera y el CHCM disminuyó continuamente entre donaciones. Conclusiones: Se observaron cambios en los parámetros eritrocitarios en los donantes recurrentes de plaquetas correspondientes a mecanismos medulares compensatorios normales sin afectación clínica de los donantes. Se sugiere realizar estudios complementarios para evaluar otras variables relacionadas con la eritropoyesis y los efectos de la circulación extracorpórea durante la plaquetoaféresis.
Introduction: The effect of repeated platelet donation by apheresis on the erythrogram is unknown for the Colombian population. Objective: evaluate the changes in the erythroid line in regular plateletpheresis donors from two blood banks in Medellin. Methods: Longitudinal study with 100 repetitive plateletpheresis donors with 3 donations or more. The source of information was the databases of the participating blood banks. Demographic data, time between donations and erythrocyte parameters were recorded in an excel database and analyzed using SPSS version 27.0 software. Variables were described using summary measures and the following statistical tests were used: Student's t-test, Mann-Whitney U, correlations, paired t-test, and Wilcoxon, considering a level of statistical significance of <0.05. Results: 58% of the donors were women, 75% were 30 years old or older, and 70% resided in the metropolitan area. No statistically significant differences were observed for hemoglobin according to sex and age group, the MCV increased in the second, third and fourth donations compared to the first, the HCM decreased in the fourth donation compared to the first, and the CHCM decreased continuously between donations. Conclusions: Changes in erythrocyte parameters were observed in recurrent platelet donors corresponding to normal compensatory medullary mechanisms without clinical involvement of the donors. Complementary studies are suggested to evaluate other variables related to erythropoiesis and the effects of extracorporeal circulation during plateletpheresis.
Subject(s)
HumansABSTRACT
OBJECTIVE: Cancer care providers' (CCPs) attitudes towards smoking cessation are influenced by many factors, including their smoking status and knowledge. Our objective was to assess CCPs' characteristics, tobacco use and smoking cessation practices in two Latin American cancer centres. DESIGN: Cross-sectional survey. SETTINGS: Two urban cancer centres located in Colombia and Mexico. PARTICIPANTS: A total of 238 CCPs. MEASURES: Online survey consisted of 28 close-ended questions adapted from the 2012 International Association for the Study of Lung Cancer survey and the Global Adult Tobacco Survey developed by the WHO. Means, frequencies and proportions were reported for each country. Factors associated to providing of smoking cessation treatment or referral at initial visit were evaluated using logistic regression. RESULTS: Current smoking prevalence was 10.5% and 12.3% among Colombian and Mexican CCPs, respectively. Around three quarters of the Colombian (86.4%) and Mexican CCPs (66.1%) considered to have inadequate training in smoking cessation. Approximately two-thirds of Colombian (67.5%) and Mexican CCPs (63.9%) reported always or most of the time asking patients about tobacco use during the initial visit. In Colombia and Mexico, the most relevant barriers for providing cessation services were (1) difficulties for motivating patients with cancer, (2) patient resistance in quitting smoking, (3) lack of local resources or referral centres for smoking cessation and (4) lack of training in smoking cessation. CCPs appointed at Instituto Nacional de Cancerología were less likely to provide cessation treatment or referral to their patients if they had less than 50% of their time devoted to patient care and were former or current smokers. The regression model for Instituto de Cancerología did not retain statistically significant variables. CONCLUSION: Our findings highlight an urgent need for assisting Latin American CCPs in their quitting efforts as well as expanding formal smoking cessation training specifically tailored to these professionals for improving patients' cancer prognosis and quality of life.
Subject(s)
Neoplasms , Smoking Cessation , Adult , Attitude , Colombia/epidemiology , Cross-Sectional Studies , Humans , Mexico/epidemiology , Neoplasms/epidemiology , Neoplasms/therapy , Quality of Life , Surveys and QuestionnairesABSTRACT
OBJECTIVE: Currently, there are discrepancies in the reports on the extent of the reduction in platelet count after platelet donation by apheresis, and its impact on mean platelet volume (MPV). This study was conducted to meta-analyze the effect of plateletpheresis on platelet count and on mean platelet volume, based on studies published between 1980 and 2018. METHODS: Medline-Pubmed, Scielo, ScienceDirect, and Scopus databases were searched from inception to December 31 2019. The PRISMA guidelines, reproducibility, and evaluation of the methodological quality were guaranteed. Heterogeneity was evaluated with DerSimonian-Laird's, publication bias with a Begg's test. Sensitivity analysis and cumulative meta-analysis were also conducted, as well as a forest plot. RESULTS: Twenty-five studies with 3769 donors were systematized to analyze platelet count, and seven studies with 1176 donors to observe MPV. Most studies were published in India and the United States. There was a postprocedure reduction in both variables. The reduction in platelet count was 14.3 × 103 /µL (95% CI 11.4 to 17.1 × 103 /µL). The reduction in MPV was 1.43 fL (95% CI 0.3 to 2.5 fL). The analysis of subgroups showed that, in the case of platelet count, the reduction is not statistically significant two weeks after donation. CONCLUSION: Platelet donation by apheresis reduces platelet count and MPV in donors, which is detrimental to the purposes of the procedure; although the decrease is not clinically significant for the donor or the recipient. This demonstrates the need for subsequent studies to evaluate variables, such as donation frequency and donation intervals, should be considered to evaluate if the reported decrease is easily compensated, without adverse consequences for donors, or if modifications in donor selection criteria are required.
Subject(s)
Mean Platelet Volume , Platelet Count , Plateletpheresis , HumansABSTRACT
RESUMEN Introducción: El conflicto armado colombiano, además de secuelas sociales y económicas en la población civil, ha implicado otras consecuencias. Los excombatientes, como la otra cara del conflicto, han sido objeto de interrogación sobre su estructura de personalidad y predisposición a conductas violentas. Se ha encontrado en parte de la población asociada al conflicto armado rasgos característicos del trastorno de personalidad antisocial (TPA) que se relacionarían con los comportamientos en contra de las convenciones sociales. Métodos: Mediante registros electrocardiográficos cuantitativos (qEEG), se evaluaron las diferencias en los patrones de actividad cortical entre un grupo de excombatientes, algunos de ellos con diagnóstico de TPA, y un grupo de control ajeno al conflicto armado y sin alteraciones psiquiátricas. Se empleó la Lista de Chequeo de Psicopatía Revisada (PCL-R) para determinar la presencia de criterios diagnósticos de TPA, así como la entrevista diagnóstica para estudios genéticos (DIGS) para clasificar la presencia de otros trastornos mentales incluidos en el CIE-10. Resultados: Se encontraron diferencias significativas en los niveles de psicopatía evaluados mediante la PCL-R. Con respecto al análisis de la potencia espectral, se observaron diferencias entre grupos en las ondas alfa-2 y beta, en regiones frontal y temporal izquierda y temporocentral izquierda respectivamente. Conclusiones: La técnica de qEEG permite evidenciarlas diferencias entre grupos en el potencial espectral en reposo, las cuales se relacionan con comportamientos desadaptativos característicos del TPA.
ABSTRACT Introduction: Although the social and economic consequences of Colombian internal conflicts mainly affected the civilian population, they also had other implications. The ex-combatants, the other side of the conflict, have been the subject of many studies that question their personality structures and antisocial features. Results suggest that ex-combatants usually have characteristics of an antisocial personality disorder (ASPD) that is related with their behavior. Methods: Quantitative EEG (qEEG) was used to evaluate differences in cortical activity patterns between an ex-combatants group and a control group. The Psychopathy Checklist-Revised (PCL-R) was used to assess the presence of ASPD in the ex-combatants group, as well as the Diagnostic Interview for Genetic Studies (DIGS) for other mental disorders classified in the DCI-10. Results: There are significant differences in psychopathy levels between groups, as well as in alpha-2 and beta waves, especially in left temporal and frontal areas for alpha-2 waves and left temporal-central regions for beta waves. Conclusions: qEEG measurements allow spectral resting potential to be differentiated between groups that are related with features typically involved in antisocial personality disorder, and to correlate them with patterns in the questionnaires and clinical interview.
Subject(s)
Humans , Male , Adult , Armed Conflicts , Rest , Behavior , Control Groups , Colombia , Electroencephalography , Mental Disorders , Antisocial Personality DisorderABSTRACT
INTRODUCTION: Although the social and economic consequences of Colombian internal conflicts mainly affected the civilian population, they also had other implications. The ex-combatants, the other side of the conflict, have been the subject of many studies that question their personality structures and antisocial features. Results suggest that ex-combatants usually have characteristics of an antisocial personality disorder (ASPD) that is related with their behaviour. METHODS: Quantitative EEG (qEEG) was used to evaluate differences in cortical activity patterns between an ex-combatants group and a control group. The Psychopathy Checklist-Revised (PCL-R) was used to assess the presence of ASPD in the ex-combatants group, as well as the Diagnostic Interview for Genetic Studies (DIGS) for other mental disorders classified in the DCI-10. RESULTS: There are significant differences in psychopathy levels between groups, as well as in alpha-2 and beta waves, especially in left temporal and frontal areas for alpha-2 waves and left temporal-central regions for beta waves. CONCLUSIONS: qEEG measurements allow spectral resting potential to be differentiated between groups that are related with features typically involved in antisocial personality disorder, and to correlate them with patterns in the questionnaires and clinical interview.