ABSTRACT
Acquired pure red cell aplasia is rare disorder of hematopoiesis. Because of the variety of reasons for PRCA optimal treatment is based on highly specialistic diagnostics. Both humoral and cellular mechanisms are involved in the pathogenesis of PRCA. Corticosteroids, cyclosporin A, high-dose intravenous immunoglobulin therapy are recommended in PRCA. Treatment failures may be successfully managed with antihuman thymocyte globulin, cyclophosphamide or azathioprine. We describe also the lots of five patients with this disorder.
Subject(s)
Red-Cell Aplasia, Pure/diagnosis , Red-Cell Aplasia, Pure/therapy , Adolescent , Adult , Female , Humans , Male , Middle Aged , Red-Cell Aplasia, Pure/etiologyABSTRACT
In order to analyse anxiety and depression states observed during the treatment of lymphoproliferative diseases, a group of 23 patients were studied. For assessment of the variables the following was used: history taking, psychological observation and psychometric techniques. The obtained results point to various dynamics of anxiety and depression. The intensity of anxiety states decreases during single as well as successive courses of chemotherapy. Depression states intensify during one course with a tendency for mood lowering with prolonged treatment duration. Therapeutic conclusions: 1. It is necessary to minimize anxiety attitudes, particularly during the first phase of the treatment (cognitive psychotherapy). 2. In deep depression it is indicated to use antidepressants and supportive psychotherapy.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/adverse effects , Anxiety/chemically induced , Depression/chemically induced , Lymphoproliferative Disorders/drug therapy , Adolescent , Adult , Aged , Cyclophosphamide/administration & dosage , Depression/therapy , Doxorubicin/administration & dosage , Female , Humans , Male , Mechlorethamine/administration & dosage , Middle Aged , Prednisone/administration & dosage , Procarbazine/administration & dosage , Vincristine/administration & dosageABSTRACT
A patient was observed who came with the following symptoms persisting for six months: paraesthesia in the lower and upper limbs, weakening of muscle strength, difficulties in walking. The high value of the mean cell volume in blood morphologic examination called attention to the possibility of vitamin B12 deficiency which had not yet manifested itself as anaemia. Further studies confirmed this suggestion. As the result of the treatment with vitamin B12 full normalization of the nervous system condition and results of examinations was achieved.
