ABSTRACT
PURPOSE: Preoperative chemoradiation (CRT) is expected to increase the rate of curative resection and complete histological response. In this trial, we investigated the efficacy of a neoadjuvant CRT regimen in gastric adenocarcinoma (NCT01565109 trial). MATERIALS AND METHODS: Patients with stage IB to IIIC gastric adenocarcinoma, endoscopy ultrasound and computed tomography-scan diagnosed, were eligible for this phase II trial. Neoadjuvant treatment consisted of 2 cycles of chemotherapy with DCF (docetaxel, cisplatin, and 5-fluorouracil [5FU]) followed by preoperative CRT with oxaliplatin, continuous 5FU and radiotherapy (45 Gy in 25 fractions of 1.8 Gy, 5 fractions per week for 5 weeks) administered before surgery. R0-resection rate, pathological complete response (pathCR) rate, and survival (progression-free survival [PFS] and overall survival [OS]) were evaluated as primary endpoints. RESULTS: Among 33 patients included, 32 patients (97%) received CRT and 26 (78.8%) were resected (R0 resection for all patients resected). Among resected patients, we report pathCR in 23,1% and pathologic major response (tumor regression grade 2 according to Mandard's classification) in 26,9%. With a median follow-up duration of 5.82 years (range, 0.4 to 9.24 years), the estimated median OS for all 33 patients was not reached; 1-, 3-, and 5-year OS rates were 85%, 61%, and 52%, respectively. Among resected patients, those whose histological response was tumor grade regression (TRG) 1-2 had significantly better OS and PFS rates than those with a TRG 3-4-5 response (p=0.019 and p=0.016, respectively). CONCLUSION: Promising results from trials involving preoperative chemoradiation followed by surgery in gastric cancer need to be further evaluated in a phase III trial.
Subject(s)
Adenocarcinoma , Stomach Neoplasms , Humans , Fluorouracil/therapeutic use , Cisplatin , Oxaliplatin/therapeutic use , Docetaxel/therapeutic use , Lenograstim/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Neoadjuvant Therapy/methodsABSTRACT
Se presentan cuatro pacientes operados de un cistoadenocarcinoma mucinoso de cabeza de páncreas, en quienes se practicó una duodenopancreatectomía cefálica ampliada. Llama la atención que en contraposición a lo que manifiesta la literatura, tres casos fueron hombres. Se destaca que a pesar de ser tumores voluminosos con un promedio aproximado de más de 8cm., todos los casos pudieron ser resecados sin mayores dificultades técnicas y no presentaron metástasis ganglionares regionales. Finalmente, se propone una metodología de estudio
Subject(s)
Humans , Male , Female , Middle Aged , Aged , Pancreatic Neoplasms/diagnosis , Cystadenocarcinoma , Pancreatic Neoplasms/surgery , Pancreatic Neoplasms/mortality , Pancreatectomy/methods , Cystadenoma , Diagnosis, Differential , Ultrasonography , Tomography, X-Ray Computed , Cholangiopancreatography, Endoscopic Retrograde , Biopsy/adverse effects , Biopsy/instrumentation , Liver Neoplasms/secondaryABSTRACT
Se presentan cuatro pacientes operados de un cistoadenocarcinoma mucinoso de cabeza de páncreas, en quienes se practicó una duodenopancreatectomía cefálica ampliada. Llama la atención que en contraposición a lo que manifiesta la literatura, tres casos fueron hombres. Se destaca que a pesar de ser tumores voluminosos con un promedio aproximado de más de 8cm., todos los casos pudieron ser resecados sin mayores dificultades técnicas y no presentaron metástasis ganglionares regionales. Finalmente, se propone una metodología de estudio