ABSTRACT
A study is presented of 59 patients with macrofocal and transmural myocardial infarction and symptoms of pulmonary edema. It was found that in patients with myocardial infarction complicated by acute left ventricular failure, reduced reserves of autoregulation naniprus is the drug of choice for control of pulmonary edema, particularly, in case of hypokinetic type of cerebral hemodynamics.
Subject(s)
Cerebrovascular Circulation/drug effects , Hemodynamics/drug effects , Myocardial Infarction/drug therapy , Nitroglycerin/pharmacology , Nitroprusside/pharmacology , Pulmonary Edema/drug therapy , Adult , Aged , Drug Evaluation , Female , Heart Failure/drug therapy , Heart Failure/etiology , Heart Failure/physiopathology , Humans , Male , Middle Aged , Myocardial Infarction/complications , Myocardial Infarction/physiopathology , Nitroglycerin/therapeutic use , Nitroprusside/therapeutic use , Pulmonary Edema/etiology , Pulmonary Edema/physiopathologyABSTRACT
Sixty-eight patients with acute macrofocal myocardial infarction were subdivided in two groups depending on the kind of treatment: routine (nitrates, beta-blocking agents, calcium antagonists) and cytochrom-C. It was found that cytochrom-C produced a positive effect on the indices of myoglobin and cardiac fractions of lactatedehydrogenase-1 and lactatedehydrogenase-2. It is shown that inclusion of cytochrom-C during the first hours of treatment of patients with macrofocal myocardial infarction resulted in an improvement of tissue breathing and amelioration of the peri-infarction zone state.
Subject(s)
Cytochrome c Group/therapeutic use , Myocardial Infarction/drug therapy , Aged , Drug Evaluation , Drug Therapy, Combination , Female , Humans , Isoenzymes , L-Lactate Dehydrogenase/blood , Male , Middle Aged , Myocardial Infarction/blood , Myoglobin/bloodSubject(s)
Atrial Fibrillation/diagnosis , Clinical Enzyme Tests , Electric Countershock , L-Lactate Dehydrogenase/blood , Adult , Atrial Fibrillation/therapy , Coronary Disease/complications , Enzyme Activation , Female , Humans , Isoenzymes , Male , Middle Aged , Prognosis , Recurrence , Rheumatic Heart Disease/complications , Time FactorsABSTRACT
Some enzymes of glycolysis and tissue respiratory were studied in 377 patients with chronic circulatory insufficiency developing due to atherosclerotic cardiosclerosis and rheumatic heart diseases. The severity of hyperenzymia was found to grow along with the increasing stages of circulatory insufficiency. A direct correlation was established between the total activity of LDH and MDH, as well as between LDH5 and MDH1. The presence of enzymatic shifts in patients with haemodynamic disorders permitted to include, with good substantiation and differentiation, such drugs into the complex therapy that favourably effect the disturbed metabolic processes.