[Use of aluminum salts for purifying oleandomycin culture broth]. / Ispol'zovanie solei aliuminiia dlia ochistki kul'tural'noi zhidkosti oleandomitsina.

It was shown that "nepheline coagulant"--Al2 (SO4)3-18H2O was effective in coagulating the admixtures in oleandomycin fermentation broth. The use of the "nepheline coagulant" in an amount of 1 to 3 per cent (by the weight) of the volume of the oleandomycin fermentation broth provided butyl acetate extraction of the antibiotic without formation of stable emulsion. Addition of the "nepheline coagulant" in an amount of 1 to 2 per cent (by the weight) to the fermentation broth markedly increased the rate of the fermentation broth filtration.

[Study of the equilibrium conditions for the extractive purification of oleandomycin]. / Izuchenie uslovii ravnovesiia pri ékstraktsionnoi ochistke oleandomitsina.

Dependence of the oleandomycin distribution coefficient on the antibiotic concentration, duration of the filtrate storage, extraction temperature and salting-out agents was studied. The distribution coefficient of oleandomycin in the system of fermentation broth filtrate--butylacetate was much lower (about 3 times) than that in the system of oleandomycin phosphate aqueous solution--butylacetate. Addition of sodium sulfate to the aqueous phase provided a significant increase in the oleandomycin distribution coefficient.