ABSTRACT
Clinic-economic analysis of antibacterial therapy of an acute peritonitis was conducted, using the method of modeling with "the tree of expanses" building. Economic advantages of ertapenem application as a start therapy of an acute peritonitis were proved.
Subject(s)
Anti-Bacterial Agents/economics , Models, Theoretical , Peritonitis/drug therapy , Peritonitis/economics , beta-Lactams/economics , Acute Disease , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/therapeutic use , Clinical Trials as Topic , Cost-Benefit Analysis , Decision Trees , Drug Therapy, Combination , Ertapenem , Health Care Costs , Humans , Treatment Outcome , beta-Lactams/administration & dosage , beta-Lactams/therapeutic useABSTRACT
The effects of glucosamine hydrochloride on the metabolic and repair processes were studied on a model of post-traumatic osteoarthrosis in the articular cartilage and on a model of post-traumatic keratitis in the cornea. The administration of glucosamine hydrochloride stimulated repair and favored inhibition of dystrophic post-traumatic processes in the connective-tissue structures. It is suggested that a probable mechanism of the drug action consists in stimulation of the synthesis of glucosaminoglycanes and collagen.
Subject(s)
Connective Tissue/injuries , Connective Tissue/metabolism , Glucosamine/pharmacology , Wound Healing/drug effects , Animals , Cornea/metabolism , Glycosaminoglycans/metabolism , Keratitis/etiology , Keratitis/metabolism , Osteoarthritis, Hip/etiology , Osteoarthritis, Hip/metabolism , Rabbits , RatsABSTRACT
The study of the antiexudative activities of voltaren, indomethacin and piroxicam in combination with glucosamine on the model of carrageenan inflammation showed that the combination makes it possible to decrease the effective doses of nonsteroidal anti-inflammatory drugs by 2-2.7 times with the preservation of the pronounced antiexudative activity. A diverse influence of aminosugar on the anti-inflammatory effect of nonsteroidal anti-inflammatory drugs depending on the sequence and routes of administration is connected with their membrane mechanisms and metabolic features of amino sugar.
