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Radiats Biol Radioecol ; 40(3): 315-8, 2000.
Article in Russian | MEDLINE | ID: mdl-10907411

ABSTRACT

Synthetic polypeptide D-(iEW) (Thymodepressin) was shown to reduce the bone marrow CFU-S in the S-phase of cell cycle. Apparently, due to this property the agent being administered 2 days before the irradiation with 4 Gy causes a prominent restoration of the CFU-S population afterwards. The 3-5 times higher value of this parameter as compared to the control (irradiation only) is likely to be connected to the increased "survival" of the Thymodepressin-protected CFU-S after the treatment with ionizing irradiation.


Subject(s)
Bone Marrow Cells/radiation effects , Hematopoietic Stem Cells/radiation effects , Peptides/pharmacology , Radiation-Protective Agents/pharmacology , Spleen/radiation effects , Animals , Bone Marrow Cells/cytology , Bone Marrow Cells/drug effects , Colony-Forming Units Assay , Female , Gamma Rays , Hematopoietic Stem Cells/cytology , Hematopoietic Stem Cells/drug effects , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Spleen/cytology , Spleen/drug effects , Time Factors
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