ABSTRACT
A large library of diversified compounds (pyrano [2,3-d]pyrimidines, pyrido[2,3-d] pyrimidines and a variety of spirooxindoles) were synthesized through a very efficient, economical and environmentally benign process utilizing magnetic nanoparticles. Ease of recovery using an external magnetic field is an additional ecofriendly attribute of this catalytic system. Most of the compounds are new; therefore, could be further explored for their pharmaceutical application. Moreover, column chromatography and recrystallisation of the products is not required as the crude products are already highly pure and hence can be used for target oriented synthesis on a wide scale.
Subject(s)
Heterocyclic Compounds/chemical synthesis , Magnetite Nanoparticles/chemistry , Nanotechnology/methods , Catalysis , Ferric Compounds/chemistry , Heterocyclic Compounds/chemistry , Indoles/chemical synthesis , Indoles/chemistry , Magnetite Nanoparticles/ultrastructure , Models, Chemical , Pyrimidines/chemical synthesis , Pyrimidines/chemistry , Solvents/chemistryABSTRACT
Multi-component reaction (MCR) involves coupling of p-bromophenol with 2-Benzothiazolethiol, malononitrile and substituted aldehydes in aqueous K(2)CO(3) as green base to synthesize 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes. This multi-component reaction thus offers a higher yield and versatility in the preparation of densely functionalized oxygen heterocycles. The newly synthesized compounds were screened for their antibacterial activities against positive and gram negative pathogenic strains to bacteria. SAR analysis was performed to explore comprehensive structure-activity relationships and a statistically reliable model to explain their antibacterial activities.
Subject(s)
Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/pharmacology , Benzopyrans/chemistry , Benzopyrans/pharmacology , Anti-Bacterial Agents/chemical synthesis , Benzopyrans/chemical synthesis , In Vitro Techniques , Quantitative Structure-Activity RelationshipABSTRACT
CuO-nanoparticles were found to be an excellent heterogeneous catalyst for C-arylation of active methylene compounds using various aryl halides. The products were obtained in good to excellent yield. The catalyst can be recovered and reused for four cycles with almost no loss in activity.
