ABSTRACT
This review will focus on a systems medicine approach to neonatal abstinence syndrome (NAS). Systems medicine utilizes information gained from the application of "omics" technology and bioinformatics (1). The omic approaches we will emphasize include genomics, epigenomics, proteomics, and metabolomics. The goals of systems medicine are to provide clinically relevant and objective insights into disease diagnosis, prognosis, and stratification as well as pharmacological strategies and evidence-based individualized clinical guidance. Despite the increasing incidence of NAS and its societal and economic costs, there has been only a very modest emphasis on utilizing a systems medicine approach, and this has been primarily in the areas of genomics and epigenomics. As detailed below, proteomics and metabolomics hold great promise in advancing our knowledge of NAS and its treatment. Metabolomics, in particular, can provide a quantitative assessment of the exposome, which is a comprehensive picture of both internal and external environmental factors affecting health.
Subject(s)
Genomics/methods , Metabolomics/methods , Neonatal Abstinence Syndrome/genetics , Neonatal Abstinence Syndrome/metabolism , Proteomics/methods , Systems Analysis , Computational Biology/methods , Epigenomics/methods , Gene Expression Profiling/methods , Humans , Infant, Newborn , Neonatal Abstinence Syndrome/diagnosisABSTRACT
Vitreous hemorrhages are uncommon in the neonatal period. This article describes a neonatal who had bilateral vitreous hemorrhages after intrauterine bowel infarction.
Subject(s)
Digestive System Surgical Procedures/methods , Disseminated Intravascular Coagulation , Fetal Diseases , Infarction , Intestinal Volvulus , Intestines/blood supply , Vitreous Hemorrhage , Anastomosis, Surgical/methods , Disseminated Intravascular Coagulation/blood , Disseminated Intravascular Coagulation/diagnosis , Disseminated Intravascular Coagulation/therapy , Enteral Nutrition/methods , Female , Fetal Diseases/diagnosis , Fetal Diseases/physiopathology , Fetal Diseases/surgery , Humans , Infant, Newborn , Infant, Small for Gestational Age , Infarction/diagnosis , Infarction/physiopathology , Infarction/surgery , Intestinal Volvulus/diagnosis , Intestinal Volvulus/physiopathology , Intestinal Volvulus/surgery , Patient Care Management/methods , Treatment Outcome , Vitreous Hemorrhage/diagnosis , Vitreous Hemorrhage/etiology , Vitreous Hemorrhage/physiopathologySubject(s)
Infarction, Middle Cerebral Artery , Seizures , Female , Humans , Infant, Newborn , Infarction, Middle Cerebral Artery/complications , Infarction, Middle Cerebral Artery/diagnosis , Infarction, Middle Cerebral Artery/physiopathology , Magnetic Resonance Imaging , Seizures/etiology , Seizures/physiopathologyABSTRACT
Little is known about the effect of inhalation of methanol and other solvents on the pregnancy and the growth of the fetus. We report a preterm male infant who developed cerebral infarcts in utero, leading to large areas of bilateral frontal cortical leukomalacia following chronic maternal inhalation of carburetor-cleaning fluid during pregnancy. The infant presented with acute fetal distress with significant metabolic acidosis at birth. Initial hypotonia was followed by generalized hypertonicity. This infant did not exhibit typical facial features of fetal alcohol syndrome.
Subject(s)
Cerebral Infarction/chemically induced , Fetal Diseases/chemically induced , Infant, Premature, Diseases/chemically induced , Leukomalacia, Periventricular/chemically induced , Prenatal Exposure Delayed Effects , Solvents/adverse effects , Substance-Related Disorders/complications , Acetone/adverse effects , Acidosis/chemically induced , Drug Combinations , Female , Humans , Infant, Newborn , Infant, Premature , Leukomalacia, Periventricular/diagnostic imaging , Male , Methanol/adverse effects , Pregnancy , Toluene/adverse effects , UltrasonographyABSTRACT
We are reporting an unusual case of cat-scratch disease in a young adolescent girl presenting with recurrent ascites. The illness started with nonspecific symptoms followed by ascites and an axillary lymph node enlargement. She had recurrent ascites for 18 months associated with constrictive pericarditis. Following pericardiectomy, she had a resolution of ascites and was back to her normal life. This is a first documented report of a constrictive pericarditis following cat scratch diseases in English literature.
